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Chemical Structure| 362606-11-9 Chemical Structure| 362606-11-9

Structure of 362606-11-9

Chemical Structure| 362606-11-9

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Product Details of [ 362606-11-9 ]

CAS No. :362606-11-9
Formula : C10H6N2
M.W : 154.17
SMILES Code : N#CC1=CC=CC2=C1C=NC=C2
MDL No. :MFCD10699232
InChI Key :PZNNHPZBZRHNDO-UHFFFAOYSA-N
Pubchem ID :12018698

Safety of [ 362606-11-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 362606-11-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 362606-11-9 ]

[ 362606-11-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 63927-22-0 ]
  • CuCN [ No CAS ]
  • [ 362606-11-9 ]
  • 2
  • [ 557-21-1 ]
  • [ 63927-22-0 ]
  • [ 362606-11-9 ]
YieldReaction ConditionsOperation in experiment
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 140℃; for 5h; [0205] A mixture of <strong>[63927-22-0]8-bromoisoquinoline</strong> (440mg, 2.14 mmol), Zn(CN)2 (500 mg, 4.27 mmol) and Pd(dppa)Cl2 (784 mg, 1.07 mmol) and DMF (5 mL) in a capped microwave reaction vial was heated at 140°C for 5 hours. The reaction mixture was filtered through Celite, washed with water (20 mL), and extracted with EtOAc (3 x 20 mL). The combined organic layers were washed with brine (10 mL), dried over Na2S04, and concentrated to give a residue which was purified with column chromatography on a silica gel with EtOAc/hexane (2/1) to give isoquinoline-8-carbonitrile as a solid. LC/MS = 155 [M+l].
 

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[ 362606-11-9 ]

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