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Chemical Structure| 361549-00-0 Chemical Structure| 361549-00-0

Structure of 361549-00-0

Chemical Structure| 361549-00-0

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Product Details of [ 361549-00-0 ]

CAS No. :361549-00-0
Formula : C8H8ClNOS
M.W : 201.67
SMILES Code : S=C(N)C1=CC(Cl)=CC=C1OC

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Application In Synthesis of [ 361549-00-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 361549-00-0 ]

[ 361549-00-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 55877-79-7 ]
  • [ 361549-00-0 ]
YieldReaction ConditionsOperation in experiment
80% With sodium monohydrogen sulfide x-hydrate; magnesium(II) chloride hexahydrate; In N,N-dimethyl-formamide; at 20℃; Exam le 10Molecular Weight: 167.6 Molecular Weight: 201 .7[00304] In a 3 -neck 100 mL round-bottomed flask, on magnetic stirrer, slurry of sodium hydrosulfide hydrate (4.33 g, 2.0 eq) and magnesium chloride hexahydrate(1.52 g, 1.0 eq.) in DMF(15mL) was added. 3-Chloro-5-methoxybenzonitrile (1.25 g, 1.0 eq) was added in one portion and the reaction mixture was stirred at room temperature for 1- 2 h. The progress of reaction was followed by TLC using ethyl acetate: hexane (1 : 1) as mobile phase. The resulting green slurry was poured in 150 mL water and the resulting precipitates were collected by filtration. The crude product was re-suspended in 1 N HC1 and stirred for 45 min., then filtered and washed with water to give intermediate- 1 (1.2 g, 80%). Mass/LCMS: 202.0.
 

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