355423-58-4|6-Bromo-7-fluoro-2H-benzo[b][1,4]oxazin-3(4H)-one| Ambeed

CAS No.: 355423-58-4

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Cat. No.: A402848 Purity: 98%

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Application In Synthesis [ 355423-58-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 355423-58-4 ]

[ 355423-58-4 ] Synthesis Path-Downstream 1~1

1
[ 103361-99-5 ]
[ 355423-58-4 ]

Yield	Reaction Conditions	Operation in experiment
44%	With N-Bromosuccinimide; In acetonitrile; at 20℃; for 5h;	INTERMEDIATE 76-Bromo-7-fluoro-4H-benzori.4]oxazin-3-oneTo a solution of Intermediate 6 (4.1 g, 25.0 mmol) in MeCN (120 mL) was added NBS (5.41 g, 30 mmol). The reaction mixture was stirred for 4 h at r.t. before addition of further NBS (0.45 g, 2.5 mmol) and MeCN (30 mL) and stirring for a further 1 h. It was then concentrated in vacuo. The resulting residue was slurried in water (10O mL). The solid material was filtered off, washed with water and dried in vacuo to give the title compound (2.7 g, 44%) as an off-white solid. deltaeta (DMSO-d6) 10.81 (IH, s), 7.12 (IH, d, J 9.4 Hz), 7.09 (IH, d, J 7.0 Hz), 4.63 (2H, s).

References: [1]Patent: WO2009/71895,2009,A1 .Location in patent: Page/Page column 96.

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CAS No. :	355423-58-4
Formula :	C₈H₅BrFNO₂
M.W :	246.03
SMILES Code :	O=C1COC2=CC(F)=C(Br)C=C2N1
MDL No. :	MFCD20441932
Boiling Point :	No data available
InChI Key :	AVHJMSMGASUDIT-UHFFFAOYSA-N
Pubchem ID :	23574320

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H312-H315-H319-H332-H335
Precautionary Statements:	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

6-Bromo-7-fluoro-2H-benzo[b][1,4]oxazin-3(4H)-one

CAS No.: 355423-58-4

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Application In Synthesis [ 355423-58-4 ]

[ 355423-58-4 ] Synthesis Path-Downstream 1~1

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