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Chemical Structure| 349405-39-6 Chemical Structure| 349405-39-6

Structure of 349405-39-6

Chemical Structure| 349405-39-6

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Product Details of [ 349405-39-6 ]

CAS No. :349405-39-6
Formula : C15H14BrNO
M.W : 304.19
SMILES Code : CN(C(C1=CC(Br)=CC=C1)=O)CC2=CC=CC=C2
MDL No. :MFCD01215178

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Application In Synthesis of [ 349405-39-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 349405-39-6 ]

[ 349405-39-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 618-89-3 ]
  • [ 103-67-3 ]
  • [ 349405-39-6 ]
YieldReaction ConditionsOperation in experiment
75% With bis(trimethylaluminum)–1,4-diazabicyclo[2.2.2]octane adduct; In tetrahydrofuran; at 130℃; for 0.133333h;Inert atmosphere; Microwave irradiation; General procedure: 4.2 General procedures: A. Microwave. Neat samples of amine (1.00 mmol) and carboxylic derivative (methyl ester or acid, 1.00 mmol) and DABAL-Me3 (202 mg, 0.8 equiv) were placed in a 5 mL microwave vial and dry THF added (1 mL) under a blanket of argon. For coupling partners containing acidic hydrogens additional DABAL-Me3 (total of 410 mg, 1.6 equiv) was used. The vial was promptly capped and placed in a CEM Discover microwave reactor. After irradiation (290 W, 130 C, 8 min) and programmed cool down (ca. 20 min). The reactions were quenched by cautious addition of HCl (2 M, 4 mL) or aqueous solutions of Rochelle salt (saturated potassium sodium tartrate, 4 mL) (CARE: methane liberated). Extraction with dichloromethane, drying (MgSO4) and evaporation frequently provided the pure products directly. If purification was required column chromatography 3:2 to 2:3 hexane:EtOAc was used for amides lacking highly polar functional groups (CH2Cl2 with 2 % v/v MeOH was used for amides bearing pendant amines, alcohols and other polar functional groups).
 

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