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Chemical Structure| 332903-47-6 Chemical Structure| 332903-47-6

Structure of 332903-47-6

Chemical Structure| 332903-47-6

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Product Details of [ 332903-47-6 ]

CAS No. :332903-47-6
Formula : C7H7ClFN
M.W : 159.59
SMILES Code : NC1=C(C)C=C(F)C=C1Cl
MDL No. :MFCD15527237
InChI Key :PLTNCEGFKZZXEI-UHFFFAOYSA-N
Pubchem ID :20434484

Safety of [ 332903-47-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P233-P260-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403+P233-P405-P501

Application In Synthesis of [ 332903-47-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 332903-47-6 ]

[ 332903-47-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 326-65-8 ]
  • [ 332903-47-6 ]
YieldReaction ConditionsOperation in experiment
Example 1c N-(2'-Chloro-4'-fluoro-6'-methylphenyl)-4-methylaniline 3.08 g (19.3 mmol) of 2-chlor-4-fluoro-6-methyl-aniline (prepared from N-acetyl-4-fluoro-2-methylaniline by chlorination followed by hydrolyses), 3.48 g (20.3 mmol) of 4-bromotoluene are dissolved in 55 ml of toluene and after the addition of 3.43 g (36 mmol) of sodium tert-butoxide, 166 mg (0.82 mmol) of tri-tert-butylphosphin and 460 mg (0.8 mmol) of bis-dibenzylideneacetone-palladium(0), the mixture is heated with stirring under nitrogen to 90 C. for 40 minutes. The usual aqueous acidic workup (50 ml water, 10 ml conc. HC, 1 g hyflo, filtration, washing the organic phase with water, drying, evaporation) gave 5.5 g of the crude product which may be purified by flash-chromatography using silica and heptane as the eluent affording 3.52 g of N2'-chloro-4'-fluoro-6'-methylphenyl)-4-methylaniline as an oily substance. 1H-NMR (400 MHz, DMSO-d6): 2.18 (s, 3H, CH3); 6.37 (d, 2H, H-C (2, 6)]; 6.92 [d, 2H, H-C (3, 5)]; 7.19 (dd, 1H, H-C (5')]; 7.32 (s, 1H, NH); 7.35 (dd, 1H, HC (3')].
 

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