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Chemical Structure| 331746-01-1 Chemical Structure| 331746-01-1

Structure of 331746-01-1

Chemical Structure| 331746-01-1

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Product Details of [ 331746-01-1 ]

CAS No. :331746-01-1
Formula : C8H6ClFO2
M.W : 188.58
SMILES Code : O=C(Cl)OC1=CC=C(C)C(F)=C1
MDL No. :MFCD27949512

Safety of [ 331746-01-1 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H300+H310+H330-H314-H290
Precautionary Statements:P501-P260-P270-P262-P234-P271-P264-P280-P284-P390-P361+P364-P303+P361+P353-P301+P330+P331-P301+P310+P330-P304+P340+P310-P305+P351+P338+P310-P403+P233-P406-P405
Class:6.1(8)
UN#:3277
Packing Group:

Application In Synthesis of [ 331746-01-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 331746-01-1 ]

[ 331746-01-1 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 405-06-1 ]
  • [ 331746-01-1 ]
  • [ 452-78-8 ]
YieldReaction ConditionsOperation in experiment
75% With boron tribromide In dichloromethane To a -70° C. solution of 3-fluoro-4-methyl anisole (1.62 g; 11.6 mmol) in CH2Cl2 (10 mL) was added dropwise BBr3 (10 mL; 12 mmol).
The reaction mixture was stirred at -70° C. for 10 min, then allowed to warm to 0° C. and stirred at 0° C. for 2 h.
The reaction was allowed to warm to RT and concentrated in vacuo and the residue was partitioned between H2O and EtOAc.
The organic phase was washed with H2O, dried (Na2SO4) and concentrated in vacuo to give 3-fluoro-4-methyl phenol (1.1 g; 75percent) as an oil.
References: [1] Patent: US6414002, 2002, B1, .
 

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