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Chemical Structure| 322-33-8 Chemical Structure| 322-33-8

Structure of 322-33-8

Chemical Structure| 322-33-8

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Product Details of [ 322-33-8 ]

CAS No. :322-33-8
Formula : C9H10FNO
M.W : 167.18
SMILES Code : CC(NC1=CC=CC(F)=C1C)=O
MDL No. :MFCD03787362

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Application In Synthesis of [ 322-33-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 322-33-8 ]

[ 322-33-8 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 443-86-7 ]
  • [ 108-24-7 ]
  • [ 322-33-8 ]
YieldReaction ConditionsOperation in experiment
100% In dichloromethane; at 20℃; for 18h;Inert atmosphere; To a solution of <strong>[443-86-7]3-fluoro-2-methylaniline</strong> (6.00 g, 48 mmol) in dry DCM (100 niL) under nitrogen was added acetic anhydride (7.6 g, 75 mmol). The reaction mixture was stirred at r.t. for 18 h then washed with water (2 x 50 mL) and NaOH solution (1 M, 2 x 50 mL). The organic layer was dried (MgSO4), filtered and concentrated in vacuo to give the title compound (8.0 g, 100percent) as a white solid. deltaH (CDCl3) 7.56 (IH, s), 7.16 (IH, q, J7.6 Hz), 6.99 (IH, br s), 6.87 (IH, t, J8.4 Hz), 2.27 (3H, s), 2.16 (3H, s).
  • 2
  • [ 443-86-7 ]
  • [ 322-33-8 ]
YieldReaction ConditionsOperation in experiment
With acetic anhydride; In ethanol; 72A. N-(3-Fluoro-2-methylphenyl)acetamide To a solution of <strong>[443-86-7]3-fluoro-2-methylaniline</strong> (2.65 g, 21.2 mmol) in EtOH (25 mL) at 0° C. was added acetic anhydride (2.60 g, 25.5 mmol). The mixture was stirred at rt overnight then concentrated under reduced pressure to give the title compound (3.54 g). LCMS: m/z 168[M+H]+
  • 3
  • [ 443-86-7 ]
  • [ 75-36-5 ]
  • [ 322-33-8 ]
YieldReaction ConditionsOperation in experiment
91% With triethylamine; In dichloromethane; at 0 - 20℃; EXAMPLE 7;Synthesis of 7-N(N?-t-butoxycarbonyl-?-alanyl)amino-6-methyl -phenoxazin-3-one7.1. Synthesis of N-acetyl-<strong>[443-86-7]2-methyl-3-fluoroaniline</strong> 1.98 ml (27.78 mmol) of acetyl chloride were added, with stirring, to a solution of 3.161 g (25.26 mmol of -methyl-3-fluoroaniline and 3.87 ml (27.78 mmol) of triethylamine in 50 ml of DCM at 0 C. The solution was allowed to warm up to ambient temperature and was stirred for 1 hour. The solution was washed with water (3 times 50 ml), the product was dried with MgSO4 and the solvent was removed under reduced pressure. After recrystallization from a mixture of mineral oil/ethyl acetate (EtOac), 3.844 g (91percent) of the title compound were obtained in the form of white crystals.
  • 4
  • [ 443-86-7 ]
  • [ 875145-49-6 ]
  • [ 322-33-8 ]
  • 5
  • [ 127-19-5 ]
  • [ 443-86-7 ]
  • [ 322-33-8 ]
 

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