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Chemical Structure| 31557-57-0 Chemical Structure| 31557-57-0

Structure of 31557-57-0

Chemical Structure| 31557-57-0

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Product Details of [ 31557-57-0 ]

CAS No. :31557-57-0
Formula : C11H8ClN
M.W : 189.64
SMILES Code : ClC1=NC=CC=C1C2=CC=CC=C2
MDL No. :MFCD04114133

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Application In Synthesis of [ 31557-57-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 31557-57-0 ]

[ 31557-57-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24228-13-5 ]
  • [ 31557-57-0 ]
YieldReaction ConditionsOperation in experiment
7.0 g (31%) With trichlorophosphate; A solution of <strong>[24228-13-5]3-phenyl-2-(1H)-pyridone</strong> (VIII; 20.0 g, 0.12 mole) and phosphorus oxychloride (300 mL) was refluxed for 6 hr and then slowly poured over crushed ice (300 mL). The resulting solution was made basic with ammonium hydroxide which led to formation of a precipitate. The mixture was extracted with ethyl ether (3*500 mL) and the combined organic extracts were dried (Na2 SO4). Concentration in vacuo gave a solid which was recrystallized from ethyl acetate to yield 7.0 g (31%) of 2-chloro-3-phenylpyridine (VI), m.p. 52-56.
 

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