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Chemical Structure| 303224-73-9 Chemical Structure| 303224-73-9

Structure of 303224-73-9

Chemical Structure| 303224-73-9

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Product Details of [ 303224-73-9 ]

CAS No. :303224-73-9
Formula : C10H10ClNO
M.W : 195.65
SMILES Code : CC1=CC(Cl)=CC(C)=C1OCC#N
MDL No. :MFCD09944331

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Application In Synthesis of [ 303224-73-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 303224-73-9 ]

[ 303224-73-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1123-63-3 ]
  • [ 590-17-0 ]
  • [ 303224-73-9 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In ethyl acetate; acetone; EXAMPLE 56 (4-Chloro-2,6-dimethyl-phenoxy)-acetonitrile 4-Chloro-2,6-dimethylphenol (5.0 g, 32 mmol), bromoacetonitrile (2.2 mL, 32 mmol) and potassium carbonate (6.6 g, 48 mmol) are combined with acetone (50 mL) and heated at reflux for 18 h. The reaction is filtered, concentrated and the residue partitioned between dichloromethane and water. The organic phase is washed with 1N HCl and water and is then dried over magnesium sulfate, concentrated and purified by column chromatography (silica, 10% ethyl acetate in hexanes) to provide the title compound. MS (EI) 195 (M)+, Cl pattern.
 

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