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Chemical Structure| 300853-97-8 Chemical Structure| 300853-97-8

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Chemical Structure| 300853-97-8

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Product Details of [ 300853-97-8 ]

CAS No. :300853-97-8
Formula : C6H10O3
M.W : 130.14
SMILES Code : O=C(O)[C@@H](O)CC1CC1
MDL No. :MFCD17171015

Safety of [ 300853-97-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H315-H318-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P310-P332+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 300853-97-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 300853-97-8 ]

[ 300853-97-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 102735-53-5 ]
  • [ 300853-97-8 ]
YieldReaction ConditionsOperation in experiment
4.30 g (85%) With sulfuric acid; sodium nitrite; In water; Step A 2-(S)-Hydroxy-3-(cyclopropyl)propanoic acid A 1 L, 3-neck flask was equipped with two dropping funnels, one containing 21.3 mL of 2.0 N H2SO4 and the other containing 21.3 mL of 2.0 N NaNO2. A mixture of 5.00 g (38.7 mmol) of 2-(S)amino-3-(cyclopropyl)propanoic acid in 28 mL of H2O at 0° C. was treated with a sufficient amount of the acid solution to dissolve the solid. The remaining H2SO4 solution and the NaNO2 solution were added, maintaining the internal temperature at less than 5° C. The resulting mixture was stirred cold for 3 h, then warned to rt and stirred for 20 h. The reaction mixture was saturated with NaCl and extracted with 4*100 mL of EtOAc. The extracts were dried over MgSO4 and concentrated to afford 4.30 g (85percent) of the title compound: 1H NMR (300 MHz) delta 0.13-0.18 (m, 2H), 0.48-0.54 (m, 2H), 0.89 (m, 1H), 1.67-1.76 (m, 2H), 4.37 (dd, J=6.4, 4.7 Hz, 1H).
 

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[ 300853-97-8 ]

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A177277 [174265-97-5]

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Reason: Optical isomers