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Chemical Structure| 289891-94-7 Chemical Structure| 289891-94-7

Structure of 289891-94-7

Chemical Structure| 289891-94-7

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Product Details of [ 289891-94-7 ]

CAS No. :289891-94-7
Formula : C10H8F4O
M.W : 220.16
SMILES Code : FC(F)(F)C1=CC=C(C(OCC=C)=C1)F
MDL No. :MFCD27948857

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Application In Synthesis of [ 289891-94-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 289891-94-7 ]

[ 289891-94-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 106-95-6 ]
  • [ 141483-15-0 ]
  • [ 289891-94-7 ]
YieldReaction ConditionsOperation in experiment
87% With potassium carbonate; In N,N-dimethyl-formamide; at 80℃; for 2h;Inert atmosphere; Allyl bromide (12.0 mL, 139 mmol) was added to a stirring mixture of 2-fluoro-5- (trifluoromethyl)phenol (1 ) (7.0 mL, 56 mmol) and K2C03 (23 g, 170 mmol) in DMF (60 mL). The mixture was stirred at 80C under N2 for 2 h, and then cooled to RT. The mixture was diluted with brine (100 mL) and the product was extracted with EtOAc (300 mL). The organic solution was washed with brine (100 mL), dried over MgS04, filtered and concentrated in vacuo. The product was purified by silica gel (0725) chromatography (120 g, 0-10% EtOAc in isohexane) to afford the title compound (2) (10.6 g, 87%) as a pale yellow oil: 1H NMR (400 MHz, CDCI3) delta: 7.25 - 7.12 (3H, m), 6.15 - 5.99 (1 H, m), 5.51 - 5.42 (1 H, m), 5.38 - 5.32 (1 H, m), 4.70 - 4.57 (2H, m)
 

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