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Rucaparib is an inhibitor ofPARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight otherPARP domains.
Synonyms: AG014699; PF-01367338; AG-014447
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Beckers, Igor ; O'Rourke, Galahad ; De Vos, Dirk ;
Abstract: The C-H arylation of indoles holds the promise to shorten synthetic routes in the production of pharmaceuticals. However, late-stage C-H activation reactions often rely on the presence of protecting groups or stoichiometric metal additives. The regiospecific C-H arylation of a highly functionalized azepino[5,3,4-cd]indole scaffold lacking directing groups via Pd(II) and Cu(II) co-catalysis is reported. The direct C-H coupling was demonstrated in the convergent synthesis of rucaparib, an FDA approved anticancer drug.
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Keywords: C-H activation ; indole ; arylation ; homogeneous catalysis ; palladium ; copper ; organic synthesis ; pharmaceuticals
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Purchased from AmBeed: 283173-50-2 ; 1408282-26-7
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CAS No. : | 283173-50-2 |
Formula : | C19H18FN3O |
M.W : | 323.36 |
SMILES Code : | O=C1NCCC2=C(C3=CC=C(CNC)C=C3)NC4=C2C1=CC(F)=C4 |
Synonyms : |
AG014699; PF-01367338; AG-014447
|
MDL No. : | MFCD11977252 |
InChI Key : | HMABYWSNWIZPAG-UHFFFAOYSA-N |
Pubchem ID : | 9931954 |
GHS Pictogram: | ![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
In Vitro:
Cell Line
| Concentration | Treated Time | Description | Reference |
HepG2 cells | 5, 10, 20, 40, 80 μM | 24, 48, 72, 96 h | AG014699 inhibited the proliferation of HepG2 cells in a time- and concentration-dependent manner. | PMC5482153 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT03533946 | Prostate Cancer | PHASE2 | TERMINATED | 2023-01-12 | Huntsman Cancer Institute, Sal... More >>t Lake City, Utah, 84112, United States Less << |
NCT03911453 | Breast Cancer | EARLY_PHASE1 | COMPLETED | 2021-07-16 | University of Arizona Cancer C... More >>enter, Tucson, Arizona, 85724, United States Less << |
NCT03413995 | Prostate Cancer Metastatic | PHASE2 | COMPLETED | 2024-09-12 | Johns Hopkins Hospital, Baltim... More >>ore, Maryland, 21205, United States|Weill Cornell Medical College, New York, New York, 10065, United States Less << |
NCT02042378 | Pancreatic Cancer|Pancreatic D... More >>uctal Adenocarcinoma Less << | PHASE2 | COMPLETED | 2025-05-16 | Cedars Sinai Medical Center, L... More >>os Angeles, California, 90048, United States|Mayo Clinic, Rochester, Minnesota, 55902, United States|New York University, New York, New York, 10012, United States|University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States|MD Anderson Cancer Center, Houston, Texas, 77030, United States|Rambam Healthcare Campus, Haifa, 31096, Israel|Hadassah Hebrew University Hospital (Sharett Institute of Oncology), Jerusalem, 91120, Israel|Tel Aviv Sourasky Medical Center, Tel Aviv, 64239, Israel Less << |
NCT01482715 | Ovarian Cancer|Fallopian Tube ... More >>Cancer|Peritoneal Cancer|Advanced Solid Tumor With Evidence of Germline or Somatic BRCA Less << | PHASE1|PHASE2 | COMPLETED | 2025-05-19 | UCSF, San Francisco, Californi... More >>a, 94155, United States|Sarah Cannon Research Institute, Sarasota, Florida, 34232, United States|Dana-Farber Cancer Institute (Part 3 only), Boston, Massachusetts, 02215, United States|Karmanos Cancer Institute, Detroit, Michigan, 48201, United States|University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States|Sarah Cannon Research Institute, Nashville, Tennessee, 37203, United States|Princess Margaret Cancer Centre, Toronto, Ontario, MSG 2M9, Canada|Sheba Medical Center, Ramat Gan, 52621, Israel|Tel Aviv Sourasky Medical Center, Tel Aviv, 632394, Israel|Hospital Vall d'Hebron, Barcelona, 8035, Spain|Guy's and St Thomas NHS Foundation Trust, London, England, SE1 9RT, United Kingdom|Royal Marsden NHS Foundation Trust, London, England, SW3 6JJ, United Kingdom|Imperial College Healthcare, London, England, W12 0HS, United Kingdom|Newcastle University, Newcastle Upon Tyne, England, UK NE7, United Kingdom|Institution of Cancer Science, University of Glasgow Wolfson Wohl Cancer Research, Glasgow, Scotland, G61 1QH, United Kingdom|University College London Cancer Institute, London, WC1E 6BT, United Kingdom Less << |
NCT03397394 | Bladder Cancer|Urothelial Carc... More >>inoma|Metastatic Urothelial Carcinoma|Renal Pelvis Carcinoma|Ureter Carcinoma|Urinary Bladder Carcinoma|Urethra Carcinoma|Muscle Invasive Bladder Cancer Less << | PHASE2 | TERMINATED | 2020-01-15 | Pinnacle Oncology, Honor Healt... More >>h, Scottsdale, Arizona, 85258, United States|University of California San Diego (UCSD), Moores Cancer Center, La Jolla, California, 92093, United States|University of California, Los Angeles (UCLA), Los Angeles, California, 90095, United States|Universityof California, Irvine, Orange, California, 92868, United States|Saint John's Health Center - John Wayne Cancer Institute (JWCI), Santa Monica, California, 90404, United States|Stanford University School of Medicine, Stanford, California, 94304, United States|Hartford Health Care Cancer Institute, Hartford, Connecticut, 06102, United States|Eastern Connecticut Hematology & Oncology Associates (ECHO), Norwich, Connecticut, 06360, United States|Medstar Georgetown University Medical Center, Washington, District of Columbia, 20007, United States|Miami Cancer Institute, Baptist Health South Florida, Miami, Florida, 33176, United States|Northwestern University, Chicago, Chicago, Illinois, 60611, United States|Indiana University - Melvin and Bren Simon Cancer Center (IUSCC), Indianapolis, Indiana, 46202, United States|The University of Iowa and Holden Comprehensive Cancer Center, Iowa City, Iowa, 52242, United States|Norton Cancer Center, Louisville, Kentucky, 40207, United States|Ochsner Cancer Institute, New Orleans, Louisiana, 70121, United States|University of Maryland, Marlene and Stewart Greenebaum Cancer Center, Baltimore, Maryland, 21201, United States|University of Michigan, Ann Arbor, Michigan, 48109, United States|Minnesota Oncology Hematology P.A. (USO - US Oncology), Minneapolis, Minnesota, 55404, United States|Comprehensive Cancer Centers of Nevada (CCCN), Las Vegas, Nevada, 89169, United States|John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey, 07601, United States|University of New Mexico UNM Cancer Research and Treatment Center, Albuquerque, New Mexico, 87102, United States|New York Oncology Hematology, P.C. (USO - US Oncology), Albany, New York, 12208, United States|Roswell Park Cancer Institute, Buffalo, New York, 14263, United States|New York - Presbyterian Hospital-Weill Cornell Medical Center, New York, New York, 10021, United States|Memorial Sloan Kettering Cancer Center, New York, New York, 10065, United States|Duke University, Duke Cancer Institute, Durham, North Carolina, 27710, United States|Stephenson Cancer Center, Oklahoma City, Oklahoma, 73104, United States|Northwest Cancer Specialists P.C. (USO - US Oncology), Portland, Oregon, 97062, United States|Providence Portland Medical Center, Portland, Oregon, 97213, United States|Oregon Health and Science University, Portland, Oregon, 97239, United States|Lehigh Valley Health Network, Allentown, Pennsylvania, 18103, United States|Penn State Hershey Medical Center, Hershey, Pennsylvania, 17033, United States|Atlantic Urology Clinics, Myrtle Beach, South Carolina, 29572, United States|University Oncology & Hematology, Chattanooga, Tennessee, 37403, United States|Urology Associates, Nashville, Tennessee, 37209, United States|Texas Oncology PA (USO - US Oncology), Dallas, Texas, 76201, United States|University of Texas, UT Health Science Center, Houston, Texas, 77030, United States|University of Utah, Huntsman Cancer Institute, Salt Lake City, Utah, 84112, United States|University of Virginia, Emily Couric Clinical Center, Charlottesville, Virginia, 22908, United States|University of Washington / Seattle Cancer Care Alliance, Seattle, Washington, 98109, United States|Froedtert & Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, United States|Centre de Lutte Contre le Cancer (CLCC) - Universite de Lyon - Centre Leon-Berard, Lyon, 69008, France|Hopital Saint-Louis, Paris, 75010, France|Centre de Lutte Contre le Cancer - Institut de Cancerologie de l'Ouest - Rene Gauducheau, Saint-Herblain, 44805, France|Institut Universitaire du Cancer de Toulouse - Oncopole, Toulouse, 31059, France|Institut Gustave Roussy, Villejuif, 94805, France|Urologische und Kinderurologische Universit?tsklinik im Malteser, Erlangen, 91054, Germany|Universitatsklinikum Munster / Urologie und Kinderurologie, Münster, 26133, Germany|Studienpraxis Urologie, Nurtingen, 72622, Germany|Fondazionerca sul Cancro ONLUS - Istituto di Candiolo IRCCS, Candiolo, 10060, Italy|IRCCS Ospedale San Raffaele - Medical Oncology Dept, Milano, 20132, Italy|Fondazione IRCCS Istituto Nazionale Tumori, Milano, 20133, Italy|Azienda Ospedaliera Universitaria Federico II Oncologia Medica, Naples, 80131, Italy|Universidad de Navarra - Clinica Universitaria de Navarra, Pamplona, Navarre, 31008, Spain|Hospital del Mar, Barcelona, 08003, Spain|Hospital Santa Creu i Sant Pau, Barcelona, 08025, Spain|Hospital Universitari Vall d'Hebron de Barcelona, Barcelona, 08035, Spain|Hospital General Universitario Gregorio Maranon, Madrid, 28007, Spain|Clinica Universitaria de Navarra Madrid, Madrid, 28027, Spain|MD Anderson Cancer Center, Madrid, 28033, Spain|Hospital Universitario 12 de Octubre, Madrid, 28041, Spain|Hospital Clínico Universitario de Santiago de Compostela, Santiago De Compostela, 15706, Spain|Sarah Cannon Research Institute - United Kingdom - London Office, London, CH63 4JY, United Kingdom|Guy's & St. Thomas' Hospital (London Oncology Clinic), London, W1G 6AF, United Kingdom Less << |
NCT04539327 | Epithelial Ovarian Cancer|Fall... More >>opian Tube Cancer|Primary Peritoneal Cancer Less << | COMPLETED | 2021-07-31 | Hospital Torrecárdenas, Almerí... More >>a, Andalucía, 04009, Spain|Hospital Universitario Virgen de la Victoria, Málaga, Andalucía, 29010, Spain|Hospital Universitario Virgen del Rocío, Sevilla, Andalucía, 41013, Spain|Hospital Universitario Nuestra Se?ora de Valme, Sevilla, Andalucía, 41014, Spain|Hospital General San Jorge, Huesca, Aragón, 22004, Spain|Hospital Clínico Universitario Lozano Blesa, Zaragoza, Aragón, 50009, Spain|Hospital Universitario Miguel Servet, Zaragoza, Aragón, 50009, Spain|Hospital del Mar, Barcelona, Catalunya, 08003, Spain|Hospital Clínic i Provincial, Barcelona, Catalunya, 08036, Spain|Instituto Valenciano De Oncologia, Valencia, Comunitat Valenciana, 46009, Spain|Hospital Universitari i Politecnic La Fe, Valencia, Comunitat Valenciana, 46026, Spain|Hospital Público Lluis Alcanyis, Xàtiva, Comunitat Valenciana, 46800, Spain|Complejo Hospitalario Universitario de Pontevedra, Pontevedra, Galicia, 36071, Spain|Hospital Universitario Son Espases, Palma De Mallorca, Islas Baleares, 07120, Spain|Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, 28942, Spain|Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, 28702, Spain|Hospital Universitario de Araba Txagorritxu, Gasteiz / Vitoria, País Basco, 01009, Spain|Clínica Universidad de Navarra, Madrid, 28027, Spain|MD Anderson Cancer Center, Madrid, 28033, Spain|Hospital Clínico San Carlos, Madrid, 28040, Spain|Hospital Universitario Fundación Jiménez Díaz, Madrid, 28040, Spain|Hospital Universitario 12 Octubre, Madrid, 28041, Spain|Centro Integral Oncológico Clara Campal, Madrid, 28050, Spain Less << | |
NCT04676334 | Metastatic Castration-Resistan... More >>t Prostate Cancer|Ovarian Cancer|Epithelial Ovarian Cancer|Fallopian Tube Cancer|Peritoneal Cancer|Other Solid Tumor Less << | PHASE3 | COMPLETED | 2023-03-08 | London Regional Cancer Centre,... More >> London, Ontario, Canada|Institut De Recherche De L'Hospital D'Ottawa, Ottawa, Ontario, Canada|Princess Margaret Hospital - Toronto, Toronto, Ontario, Canada|Centre Hospitalier de L'Universite de Montreal (CHUM), Montréal, Quebec, Canada|CIUSSS de l'Estrie - CHUS, Sherbrooke, Quebec, Canada|Carmel Medical Center, Haifa, Israel|Meir Medical Center, Kfar Saba, Israel|Istituto per la Ricerca e la Cura del Cancro Istituto di Candiolo, Candiolo, Torino, Italy|Azienda Ospedaliero-Universitaria di Bologna - Policlinico S.Orsola-Malpighi, Bologna, Italy|Istituto Europeo di Oncologia, Milano, Italy|Istituto Nazionale per lo studio e la cura dei tumori "Fondazione Pascale" Oncologia Medica, Napoli, Italy|Fondazione Policlinico Universitario Agostino Gemelli, Roma, Italy|Bia?ostockie Centrum Onkologii im. Marii Sk?odowskiej-Curie, Bia?ystok, Podlaskie, Poland|Wojewódzki Szpital Specjalistyczny w Olsztynie, Olsztyn, Warminsko-Mazurskie, Poland|Republic Clinical Oncology Dispensary of the Ministry of Healthcare of Republic of Bashkortostan, Ufa, Bashkortosta, Russian Federation|State Healthcare Institution Oncologic Dispensary No. 2 - Health Department of Krasnodar Region, Sochi, Krasnodar, Russian Federation|Republican oncological dispensary of Republic of Mordovia, Saransk, Mordovia, Russian Federation|Arkhangelsk Clinical Oncological Dispensary, Arkhangel'sk, Primorskiy, Russian Federation|Pyatigorsk Oncological Dispensary, Pyatigorsk, Stavropol, Russian Federation|N.N. Blokhin Russian Cancer Research Center, Moscow, Russian Federation|Omsk Regional Clinical Oncologic Dispensary, Omsk, Russian Federation|Ryazan Regional Clinical Oncology Dispensary, Ryazan', Russian Federation|Almazov National Medical Research Centre, Saint Petersburg, Russian Federation|University College London Hospitals, London, England, United Kingdom|East and North Hertfordshire NHS Trust, Middlesex, England, United Kingdom Less << |
NCT02952534 | Metastatic Castration Resistan... More >>t Prostate Cancer Less << | PHASE2 | COMPLETED | 2021-07-27 | University of Alabama at Birmi... More >>ngham, Birmingham, Alabama, 35294, United States|Mayo Clinc, Phoenix, Arizona, 85259, United States|Arizona Oncology Associates, Tucson, Arizona, 85704, United States|Alliance Research Centers, Laguna Hills, California, 92653, United States|VA Greater Los Angeles Healthcare System, Los Angeles, California, 90073, United States|University of Southern California, Los Angeles, California, 90211, United States|Stanford University, Palo Alto, California, 94305, United States|Sharp Memorial Hospital, San Diego, California, 92123, United States|Pacific Hematology Oncology Associates, San Francisco, California, 94115, United States|San Francisco VA Health Care System, San Francisco, California, 94143, United States|UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, 94158, United States|Redwood Regional Medical Group, Santa Rosa, California, 95406, United States|Kaiser Permanente Medical Center (Vallejo), Vallejo, California, 94589, United States|Rocky Mountain Cancer Centers, Aurora, Colorado, 80012, United States|Yale School of Medicine, New Haven, Connecticut, 06510, United States|4701 Ogletown Stanton Rd., Newark, Delaware, 19713, United States|Georgetown University Medical Center, Washington, District of Columbia, 20007, United States|Boca Raton Community Hospital, Inc., Boca Raton, Florida, 33486, United States|Florida Cancer Specialists, Fort Myers, Florida, 33980, United States|University of Florida Health Cancer Center, Orlando, Florida, 32806, United States|Moffitt Cancer Center, Tampa, Florida, 33612, United States|Atlanta Urological Group, Atlanta, Georgia, 30312, United States|University of Chicago Comprehensive Cancer Center, Chicago, Illinois, 60637, United States|Ochsner Medical Center, New Orleans, Louisiana, 70121, United States|University of Maryland Greenebaum Cancer Center, Baltimore, Maryland, 21201, United States|Walter Reed Hospital, Bethesda, Maryland, 48202, United States|Massachusetts General Hospital, Boston, Massachusetts, 02114, United States|VA Ann Arbor Healthcare System, Ann Arbor, Michigan, 48105, United States|Henry Ford Hospital, Detroit, Michigan, 48202, United States|Fairview Hospital, Edina, Minnesota, 55435, United States|Minnesota Oncology Hematology, P.A., Minneapolis, Minnesota, 55404, United States|Minnesota Veterans Research Institute, Minneapolis, Minnesota, 55417, United States|HCA Midwest Division - Kansas City, Kansas City, Missouri, 64132, United States|Alegent Health Bergan Mercy Hospital , GU Research Network, Omaha, Nebraska, 68130, United States|Nebraska Cancer Specialists, Omaha, Nebraska, 68130, United States|Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, 89119, United States|Premier Urology Associates dba/AdvanceMed Research, Lawrenceville, New Jersey, 08648, United States|Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, 08901, United States|Roswell Park, Buffalo, New York, 14263, United States|NYU Perlmutter Cancer Center, New York, New York, 10016, United States|Memorial Sloan Kettering CC, New York, New York, 10065, United States|Weill Cornell Medical College/NewYork-Presbyterian Hospital, New York, New York, 10065, United States|Premier Medical Group of the Hudson Valley PC, Poughkeepsie, New York, 12301, United States|University of Rochester, Rochester, New York, 14642, United States|SUNY Upstate Medical University, Syracuse, New York, 13210, United States|Carolina Urology Partners, Concord, North Carolina, 28025, United States|The Urology Group, Cincinnati, Ohio, 45212, United States|Kettering Cancer Center, Kettering, Ohio, 45429, United States|Clinical Research Solutions, Middleburg Heights, Ohio, 44130, United States|VA Portland Health Care System, Portland, Oregon, 97219, United States|Consultants in Medical Oncology Hematology, Horsham, Pennsylvania, 19044, United States|SCRI - Tennessee Oncology, Nashville, Tennessee, 37203, United States|Texas Oncology Medical City Dallas, Dallas, Texas, 75320, United States|UT Southwestern Medical Center, Dallas, Texas, 75390, United States|UT Health Science Center, Houston, Texas, 77030, United States|Texas Oncology - Tyler, Tyler, Texas, 75702, United States|Virginia Oncology Associates, Norfolk, Virginia, 23502, United States|VA Puget Sound, Seattle, Washington, 98108, United States|Northern Cancer Insitute, St. Leonards, Saint Leonards, New South Wales, 2065, Australia|Royal Hobart Hospital, Hobart, Tasmania, 7000, Australia|Peninsula & Southeast Oncology, Frankston, Victoria, 3199, Australia|Barwon Health, University Hospital Geelong, Geelong, Victoria, 3220, Australia|Cabrini Hospital, Malvern, Victoria, 3144, Australia|Southside Cancer Care Centre, Miranda, 2228, Australia|Orange Health Services, Orange, 2800, Australia|St John of God Hospital, Subiaco, Subiaco, 6008, Australia|Riverina Cancer Care Centre, Wagga Wagga, 2650, Australia|ZNA Middelheim, Antwerp, 2020, Belgium|Universitair Ziekenhuis Gent, Gent, B-9000, Belgium|AZ Groeninge, Kortrijk, 8500, Belgium|CHU Sart-Tilman, Liège, 4000, Belgium|Equipe de Recherche Clinique, Département d'Oncologie/Hématologie, Liège, 4000, Belgium|AZ DELTA, Roeselare, B-8800, Belgium|Juravinski Cancer Centre Hamilton Health Services, Hamilton, Ontario, L8V5C2, Canada|London Health Science Center - Victoria Hospital, London, Ontario, N6A 4L6, Canada|The Ottawa Hospital, Ottawa, Ontario, K1H8L6, Canada|Princess Margaret Hospital, Toronto, M5G 2M9, Canada|Copenhagen University Hospital, Copenhagen, 2100, Denmark|Herlev Hospital, Herlev, 2730, Denmark|Vejle Sygehus, Vejle, 7100, Denmark|Centre Fran?ois Baclesse, Caen, 14000, France|Centre Georges Fran?ois Leclerc, Dijon, 21079, France|Clinique Victor Hugo Centre Jean Bernard, Le Mans, 72000, France|H?pital Privé La Louvière, Lille, 59800, France|Polyclinique de Gentilly (Centre D'Oncologie De Gentilly), Nancy, 54100, France|Institut Curie, Paris, 75248, France|H?pital Privé des C?tes d'Armor, Plérin, 22190, France|CRLCC Eugene Marquis, Rennes, 35042, France|Gemeinschaftspraxis fur Hamatologie & Onkologie, Augsburg, 86150, Germany|Charite Universitatsmedizin Berlin, Berlin, 12200, Germany|Universitatsklinikum Carl Gustav Carus, Dresden, 01307, Germany|Universitatsklinikum Dusseldorf, Dusseldorf, 40225, Germany|Urologische Gemeinschaftspraxis, Emmendingen, 79312, Germany|Universitaetsklinikum Hamburg-Eppendorf (UKE), Hamburg, 20246, Germany|Universitaetsklinikum Heidelberg, Heidelberg, 69120, Germany|Universitatsklinikum Jena, Jena, 07747, Germany|Universit?tsklinik K?ln, K?ln, 50937, Germany|Universit?tsklinikum Schleswig-Holstein, Lübeck, 23538, Germany|Medizinischen Fakult?t Mannheim der Universit?t Heidelberg, Mannheim, 68167, Germany|Studienpraxis Urologie, Nürtingen, 72622, Germany|University of Tuebingen, Tuebingen, 72076, Germany|Die Gesundhehitsunion DGU, Wuppertal, 42103, Germany|Cork University Hospital, Cork, T12 DFK4, Ireland|St. Vincent's University Hospital, Dublin, D04T6F4, Ireland|St James's Hospital, Dublin, D08 NHY1, Ireland|Adelaide & Meath Hospital, Incorporating the National Children's Hospital, Dublin, Dublin 24, Ireland|Mater Misericordiae University Hospital, Dublin, Dublin 7, Ireland|Rambam Health Care Campus (RHCC), Rambam Medical Center, Haifa, 3109601, Israel|Hadassah University Hospital, Jerusalem, 71120, Israel|Meir Medical Center, Kfar Saba, 4428164, Israel|Rabin Medical Center-Beilinson Campus, Petach Tikva, 4941492, Israel|Chaim Sheba Medical Center, Ramat Gan, 52621, Israel|The Tel Aviv Sourasky Medical Center (Ichilov Hospital), Tel Aviv, 64231, Israel|Ospedale San Donato, Azienda USLSUDEST, Arezzo, 52100, Italy|Ospedale Santa Maria delle Croci, Faenza, 48018, Italy|IRCCS Istituto Nazionale dei Tumori (INT), Milano, 20133, Italy|IEO Instituto Europeo di Oncologia, Milano, 20141, Italy|University of Modena and Reggio Emilia Medical Oncology, Modena, 41124, Italy|Azienda Ospedaliera San Camillo-Forlanini, Rome, 00152, Italy|Azienda Opsedaliera S. Maria di Terni, Terni, 05100, Italy|Santa Chiara Hospital, Dept Medical Oncology, Trento, 38122, Italy|Hospital Universitari Germans Trias i Pujol, Badalona, 08916, Spain|Hospital del Mar, Servicio de Oncología, Barcelona, 08003, Spain|Hospital Clínic i Provincial de Barcelona-Oncology, Barcelona, 08036, Spain|Instituto Catalan de Oncologia, Barcelona, 08908, Spain|Hospital Universitari Germans Trias i Pujol, Barcelona, 08916, Spain|Hospital General Universitario de Guadalajara, Guadalajara, 19002, Spain|Hospital Universitario Lucus Augusti., Lugo, 27003, Spain|MD Anderson Cancer Center - Madrid, Madrid, 28033, Spain|Hospital Universitario Ramón y Cajal, Madrid, 28034, Spain|Hospital 12 de Octubre, Madrid, 28041, Spain|Hospital Universitario La Paz, Madrid, 28046, Spain|Hospital Puerta de Hierro-Majadahonda, Madrid, 28222, Spain|Hospital Universitario Central de Asturias, Oviedo, 33011, Spain|Corporacio Sanitaria Parc Tauli, Sabadell, 8208, Spain|Marques de Valdecilla University Hospital (HUMV), Santander, 39008, Spain|Hospital Universitario Virgen del Rocío, Sevilla, 41013, Spain|Instituto Valenciano de Oncologia IVO, Valencia, 46009, Spain|Wexham Park Hospital, Slough, Berkshire, SL2 4HL, United Kingdom|Mount Vernon Cancer Centre, Northwood, England, HA6 2RN, United Kingdom|Royal Marsden Hospital, Sutton, Surrey, SM2 5PT, United Kingdom|Oxford University Hospitals, Headington, OC3 7LJ, United Kingdom|Royal Liverpool Hospital, Liverpool, L7 8XP, United Kingdom|London Health Science Center - Victoria Hospital, London, N6A 4L6, United Kingdom|Guy's Hospital, London, SE1 9RT, United Kingdom|Sarah Cannon Research Institutute - UK, London, W1G 6AD, United Kingdom|Southampton General Hospital, Southampton, SO16 6YD, United Kingdom|Musgrove Park Hospital, Taunton, TA1 5DA, United Kingdom|The Clatterbridge Cancer Centre NHS Foundation Trust, Wirral, CH63 4JY, United Kingdom Less << |
NCT04171700 | Solid Tumor | PHASE2 | TERMINATED | 2022-07-15 | UCLA Medicine Hematology and O... More >>ncology, Los Angeles, California, 90024, United States|UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, 94158, United States|Florida Cancer Specialists, Fort Myers, Florida, 33901, United States|Florida Cancer Specialists, Saint Petersburg, Florida, 33705, United States|H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, 33612, United States|Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, 60611, United States|University of Iowa Hospital and Clinics, Iowa City, Iowa, 52242, United States|Beth Israel Deaconess Medical Cancer Surgical Pavilion, Boston, Massachusetts, 02215, United States|Dana Farber Cancer Institute, Boston, Massachusetts, 02215, United States|New York Cancer And Blood Specialists, Bronx, New York, 10469, United States|Columbia University Irving Medical Center, New York, New York, 10032, United States|New York Cancer and Blood Specialists, Port Jefferson Station, New York, 11776, United States|Ohio State University, Columbus, Ohio, 43210, United States|Stephenson Cancer Center - The University of Oklahoma, Oklahoma City, Oklahoma, 73104, United States|University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States|UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, 15232, United States|SCRI/Tennessee Oncology - Chattanooga, Chattanooga, Tennessee, 37404, United States|Tennessee Oncology, Nashville, Tennessee, 37203, United States|Seattle Cancer Care Alliance/University of Washington, Seattle, Washington, 98109, United States Less << |
NCT03499444 | Advanced Solid Tumor | PHASE1 | COMPLETED | 2022-04-13 | Division of Medical Oncology, ... More >>Hyogo Cancer Center, Akashi, Hyogo, 673-8558, Japan|Department of Gynecologic Oncology, Saitama Medical Univeristy international Medical Center, Hidaka, Saitama, 350-1298, Japan|Department of Breast and Medical Oncology, National Cancer Center Hospital, Tsukiji, Tokyo, 104-0045, Japan Less << |
Tags: Rucaparib | AG014699 | PF-01367338 | AG 014699 | AG-014699 | PF01367338 | PF 01367338 | PF-01367338 | PARP | poly ADP ribose polymerase | AG14644 | Capan-1 | BRCA2 | BRCA1 | PARP-1 inhibitor | PARP-2 inhibitor | PARP-3 inhibitor | PARP inhibitor | CRPC research | hexose-6-phosphate dehydrogenase | PARP-1 inhibitor | castration-resistant prostate cancer | H6PD inhibitor | 283173-50-2
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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