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Type HazMat fee for 500 gram (Estimated)
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Chemical Structure| 279252-26-5 Chemical Structure| 279252-26-5

Structure of 279252-26-5

Chemical Structure| 279252-26-5

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Product Details of [ 279252-26-5 ]

CAS No. :279252-26-5
Formula : C8H5BrClF3
M.W : 273.48
SMILES Code : FC(C1=CC=C(C(Cl)=C1)CBr)(F)F
MDL No. :MFCD14155638
InChI Key :AIZUUFYFLNVTQX-UHFFFAOYSA-N
Pubchem ID :22058559

Safety of [ 279252-26-5 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P403+P233-P501
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 279252-26-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 279252-26-5 ]

[ 279252-26-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 56456-51-0 ]
  • [ 279252-26-5 ]
YieldReaction ConditionsOperation in experiment
99% With carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; at 0 - 30℃; for 2h; To a solution of <strong>[56456-51-0]2-chloro-4-trifluoromethylbenzyl alcohol</strong> (2.23 g) and triphenylphosphine (4.17 g) in tetrahydrofuran (25 ml) was added carbon tetrabromide (5.27 g) , and the mixture was stirred at room temperature for 2 hr. The reaction solution was concentrated, hexane and diethyl ether was added to the residue, and the insoluble material was filtered off. The mother liquor was concentrated, and the obtained residue was subjected to silica gel column chromatography and eluted with ethyl acetate-hexane (0:1 - 1:4, v/'v) to give 2-chloro-4- trifluoromethylbenzylbromide (2.90 g, yield: 99%) as a colorless oil. 1H-NMR (300 MHz, CDCl3) 5:4.59 (2 H, s) , 7.46 - 7.60 (2 H, m) , 7.65 (1 H, s)
  • 2
  • [ 56456-51-0 ]
  • [ 558-13-4 ]
  • [ 279252-26-5 ]
YieldReaction ConditionsOperation in experiment
99% With triphenylphosphine; In tetrahydrofuran; diethyl ether; hexane; Reference Example 130 To a solution of <strong>[56456-51-0]2-chloro-4-(trifluoromethyl)benzyl alcohol</strong> (2.23 g) and triphenylphosphine (4.17 g) in tetrahydrofuran (25 ml) was added carbon tetrabromide (5.27 g), and the mixture was stirred at room temperature for 2 hr. The reaction solution was concentrated, hexane and diethyl ether were added to the residue, and the insoluble substance was removed by filtration. The filtrate was concentrated, and the obtained residue was subjected to silica gel column chromatography and eluted with ethyl acetate-hexane (0:1 to 1:4, v/v) to give 2-chloro-4-(trifluoromethyl)benzyl bromide (2.90 g, yield 99%) as a colorless oil. 1H-NMR (300 MHz, CDCl3) delta:4.59 (2 H, s), 7.46 - 7.60 (2 H, m), 7.65 (1 H, s).
 

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