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Chemical Structure| 27866-47-3 Chemical Structure| 27866-47-3

Structure of 27866-47-3

Chemical Structure| 27866-47-3

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Product Details of [ 27866-47-3 ]

CAS No. :27866-47-3
Formula : C10H11N
M.W : 145.20
SMILES Code : CC1=C(C)C2=C(NC=C2)C=C1
MDL No. :MFCD18449574

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Application In Synthesis of [ 27866-47-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 27866-47-3 ]

[ 27866-47-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 13061-96-6 ]
  • [ 610794-15-5 ]
  • [ 27866-47-3 ]
YieldReaction ConditionsOperation in experiment
91.8% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; at 90℃; for 5h;Inert atmosphere; A mixture of bromide 1 (1.0 g, 4.78 mmol), methyl boronic acid (860 mg, 14.3 mmol), Pd(dppf)2Cl2 (194 mg, 0.239 mmol), and K2CO3 (1.32 g, 9.56 mmol) in dioxane (20 mL) was degassed and stirred at 90 C. for 5 h under nitrogen. The reaction mixture was concentrated, and the residue was purified by silica gel chromatography (EtOAc/petroleum ether=1/4) to give the desired product (636 mg, 4.39 mmol, 91.8%) as a white solid.
  • 2
  • [ 109179-31-9 ]
  • [ 27866-47-3 ]
 

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