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Chemical Structure| 2729-19-3 Chemical Structure| 2729-19-3

Structure of 2729-19-3

Chemical Structure| 2729-19-3

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Product Details of [ 2729-19-3 ]

CAS No. :2729-19-3
Formula : C15H13FO2
M.W : 244.26
SMILES Code : O=C(C1=CC=C(OC)C=C1)CC2=CC=C(F)C=C2
MDL No. :MFCD11545161

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Application In Synthesis of [ 2729-19-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2729-19-3 ]

[ 2729-19-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 100-66-3 ]
  • [ 459-04-1 ]
  • [ 2729-19-3 ]
YieldReaction ConditionsOperation in experiment
60% With aluminum (III) chloride; In dichloromethane; at 0 - 20℃; General procedure: Anhydrous AlCl3 (172.9 mg, 1.3 mmol, 1.3 equiv) was added to a mixtureof 2-phenylacetyl chloride (154.0 mg, 1.0 mmol, 1.0 equiv) and toluene (92.0 mg, 1.0 mmol, 1.0 equiv) in anhydrous DCM (15 mL) at 0C. The reaction mixture was stirred at r.t. until the reaction was completed (detected by TLC). The mixture was poured into water and extractedwith DCM (3 × 20 mL). The combined organic layers weredried over Mg2SO4 and concentrated in vacuo. The residue was purifiedby column chromatography on silica gel [ethyl acetate/petroleumether (EA/PE), 1:50 to 1:15] to give 2-phenyl-1-(p-tolyl)ethan-1-one (3b; 130.2 mg, 62%) as a white solid. Similarly, compounds 3e, 3f, 3h-3o, 3q, 3t, and 3u were obtained using this method.
 

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