Name: 2683-82-1|2,3,7,8,12,13,17,18-Octaethyl-21h,23h-porphine|97%
Brand: Ambeed
SKU: A613242
Price: 45.0 USD
Availability: InStock
Rating: 92 (40 reviews)

1
[ 24477-51-8 ]
[ 2683-82-1 ]

Yield	Reaction Conditions	Operation in experiment
	With o-tetrachloroquinone In dichloromethane for 24h; Ambient temperature; Yield given;
0.99 g	With oxygen In water; benzene for 24h;

Reference： [1]Fischer; Baeumler [Justus Liebigs Annalen der Chemie, 1929, vol. 468, p. 61,74]
[2]Tang; Verkade [Journal of Organic Chemistry, 1994, vol. 59, # 25, p. 7793 - 7802]
[3]Milgram, Benjamin C.; Eskildsen, Katrine; Richter, Steven M.; Scheidt, W. Robert; Scheidt, Karl A. [Journal of Organic Chemistry, 2007, vol. 72, # 10, p. 3941 - 3944]

2
[ 109-99-9 ]
[ 2683-82-1 ]
C₃₆H₄₄N₄^(2-)*4C₄H₈O*2Li⁽¹⁺⁾ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
90%	With lithium hexamethyldisilazane at 50 - 60℃; for 0.5h;

Reference： [1]Arnold, John [Journal of the Chemical Society. Chemical communications, 1990, # 14, p. 976 - 978]

3
[ 16200-52-5 ]
[ 50-00-0 ]
[ 2683-82-1 ]

Yield	Reaction Conditions	Operation in experiment
66.4%	With toluene-4-sulfonic acid In water; benzene for 8h; Dean-Stark; Reflux; Inert atmosphere;
	In acetic acid for 1h; Heating; Yield given;
	With oxygen 1.) benzene, 55 deg C, 15 h, 2.) r.t.; Yield given. Multistep reaction;

With cetyltrimethylammonium chloride In methanol; aq. phosphate buffer at 25℃; for 24h; Sealed tube;

Reference： [1]Sessler, Jonathan L.; Mozaffari, Azadeh; Johnson, Martin R. [Organic Syntheses, 1992, vol. 70, p. 68 - 68]
[2]Rohrer; Ocampo; Callot [Synthesis, 1994, # 9, p. 923 - 925]
[3]Tang; Verkade [Journal of Organic Chemistry, 1994, vol. 59, # 25, p. 7793 - 7802]
[4]Alexy, Eric J.; Hintz, Carl W.; Hughes, Hubert M.; Taniguchi, Masahiko; Lindsey, Jonathan S. [Organic and Biomolecular Chemistry, 2015, vol. 13, # 39, p. 10025 - 10031]

4
(2,3,7,8,12,13,17,18-octaethylporphyrinato)nickel(II) [ No CAS ]
[ 2683-82-1 ]

Yield	Reaction Conditions	Operation in experiment
97%	With ethylene glycol In trifluoroacetic acid at 20℃; for 0.333333h;

Reference： [1]Battersby, Alan R.; Jones, Keith; Snow, Roger J. [Angewandte Chemie, 1983, vol. 95, # 9, p. 742 - 743]

5
[ 67514-01-6 ]
[ 2683-82-1 ]

Yield	Reaction Conditions	Operation in experiment
61%	With phosphorus trichloride In chloroform at 50℃; for 0.0833333h; further reagent;

Reference： [1]Andrews, Laura E.; Bonnett, Raymond; Ridge, Richard J.; Appelman, Evan H. [Journal of the Chemical Society. Perkin transactions I, 1983, # 1, p. 103 - 107]

6
[ 159428-02-1 ]
[ 2683-82-1 ]

Yield	Reaction Conditions	Operation in experiment
	With Dimethoxymethane; chloranil; toluene-4-sulfonic acid 1) CH₂Cl₂, rt, 12 h; Yield given. Multistep reaction;
750 mg	Stage #1: α-(Hydroxymethyl)-3,4-diethylpyrrole With hydrogen bromide In methanol at 20℃; for 2h; Stage #2: With chloranil In tetrahydrofuran at 20℃; for 5h;

Reference： [1]Ono, Noboru; Kawamura, Hisayuki; Bougauchi, Masahiro; Maruyama, Kazuhiro [Tetrahedron, 1990, vol. 46, # 21, p. 7483 - 7496]
[2]Syrbu; Lyubimova; Semeikin [Chemistry of Heterocyclic Compounds, 2004, vol. 40, # 10, p. 1262 - 1270]

7
[ 67106-41-6 ]
[ 2683-82-1 ]

Yield	Reaction Conditions	Operation in experiment
90%	With recorcinol at 160℃; for 1h;

Reference： [1]Verne-Mismer, J.; Ocampo, R.; Callot, H. J.; Albrecht, P. [Tetrahedron Letters, 1988, vol. 29, # 3, p. 371 - 374]

8
2,3,7,8,12,13,17,18-octaethyl-21H,23H-porphine copper(II) [ No CAS ]
[ 2683-82-1 ]

Yield	Reaction Conditions	Operation in experiment
97%	With ethylene glycol In trifluoroacetic acid at 20℃; for 0.166667h;
	With sulfuric acid In water; acetic acid at 24.85℃;
	With trifluoroacetic acid In acetic acid at 34.85 - 54.85℃;

Reference： [1]Battersby, Alan R.; Jones, Keith; Snow, Roger J. [Angewandte Chemie, 1983, vol. 95, # 9, p. 742 - 743]
[2]Sokolova; Lomova; Klueva; Suslova; Mayzlish; Shaposhnikov [Molecules, 2000, vol. 5, # 6, p. 775 - 785]
[3]Kuvshinova; Kuz'min; Dudkina; Pukhovskaya; Semeikin; Golubchikov [Russian Journal of General Chemistry, 2002, vol. 72, # 1, p. 133 - 136]

9
[ 79038-29-2 ]
[ 2683-82-1 ]

Yield	Reaction Conditions	Operation in experiment
	With lithium aluminium tetrahydride In tetrahydrofuran for 0.0833333h;

Reference： [1]Fuhrhop,J.H.; Baumgartner,E.; Bauer,H. [Journal of the American Chemical Society, 1981, vol. 103, p. 5854]

10
[ 79045-97-9 ]
[ 2683-82-1 ]

Yield	Reaction Conditions	Operation in experiment
	With lithium aluminium tetrahydride In tetrahydrofuran for 0.0833333h;

Reference： [1]Fuhrhop,J.H.; Baumgartner,E.; Bauer,H. [Journal of the American Chemical Society, 1981, vol. 103, p. 5854]

11
[ 67-56-1 ]
[ 67-66-3 ]
[ 2683-82-1 ]
[ 80612-49-3 ]

Yield	Reaction Conditions	Operation in experiment
5.5%	With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In water for 2h;

Reference： [1]Callot, H. J.; Fischer. J.; Weiss, R. [Journal of the American Chemical Society, 1982, vol. 104, # 5, p. 1272 - 1276]

12
[ 71-23-8 ]
[ 2683-82-1 ]
[ 132280-46-7 ]

Yield	Reaction Conditions	Operation in experiment
82%	With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In dichloromethane for 3h; Heating;

Reference： [1]Vicente, M. Graca H.; Smith, Kevin M. [Tetrahedron, 1991, vol. 47, # 34, p. 6887 - 6894]

13
[ 64-17-5 ]
[ 2683-82-1 ]
[ 129111-90-6 ]

Yield	Reaction Conditions	Operation in experiment
91%	With N-Bromosuccinimide; hydrogen bromide; acetic acid In chloroform for 0.0833333h; Ambient temperature;

Reference： [1]Bonnett, Raymond; Campion-Smith, Ian H.; Kozyrev, Andrei N.; Mironov, Andrei F. [Journal of Chemical Research, Miniprint, 1990, # 5, p. 1015 - 1043]

14
[ 2916-68-9 ]
[ 2683-82-1 ]
[ 132280-48-9 ]

Yield	Reaction Conditions	Operation in experiment
50%	With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In dichloromethane for 48h; Ambient temperature;

Reference： [1]Vicente, M. Graca H.; Smith, Kevin M. [Tetrahedron, 1991, vol. 47, # 34, p. 6887 - 6894]

15
[ 2683-82-1 ]
[ 74-88-4 ]
[ 30116-09-7 ]

Yield	Reaction Conditions	Operation in experiment
61%	With sodium formate In chloroform for 24h; Reflux;
60%	With acetic acid In chloroform for 5h; Heating;

Reference： [1]Ivanova; Nam, Dao Tkhe; Glazunov; Semeikin; Mamardashvili [Russian Journal of General Chemistry, 2012, vol. 82, # 7, p. 1272 - 1277]
[2]Cavaleiro; Condesso; Jackson; et al. [Tetrahedron Letters, 1984, vol. 25, # 52, p. 6047 - 6048]

16
[ 2683-82-1 ]
[ 3133-98-0 ]

Yield	Reaction Conditions	Operation in experiment
78%	With trifluoroacetic acid; sodium nitrite at 20℃; for 0.0833333h;	5-Nitro-2,3,7,8,12,13,17,18-octaethylporphyrin (2). To 0.04 g (0.0748 mmol) of porphyrin 1 in 3 mL of trifl uoroacetic acid, 0.026 g (0.374 mmol) of NaNO2 was added and mixed at room temperature for 5 min. Chloroform and water were added to the reaction mixture. The organic layer was separated, washed with water, a NaHCO3 solution, again with water, then dried with Na2SO4, and evaporated to a minimal volume. The residue was chromatographed on aluminum oxide with a hexane-dichloromethane (1 : 1) mixture and then with dichloromethane. Yield 0.034 g (0.0586 mmol, 78%). EAS (H2Cl2), λ, nm (log ε): 624 (3.67), 571 (3.74), 537 (3.88), 502 (4.05), 396 (5.08). 1H NMR spectrum, δ, ppm: 10.25 s (2H) and 10.10 s (1H, meso-H), 4.11-4.02 m (12H) and 3.75 s (4H, CH2), 1.93-1.85 m (18H) and 1.69-1.60 m (6H, CH3), -3.85 s and -3.95 s (2H, NH). Mass spectrum, m/z (Irel, %): 579.1 (98) [M] + (calculated for 3645N5O2: 579.8).
31%	With nitronium tetrafluoborate In pyridine; chloroform at 80℃; for 6h;
	With nitric acid; acetic acid for 0.0222222h;

	Multi-step reaction with 3 steps 1: dichloromethane; methanol / 1 h / 20 °C 2: iodine / dichloromethane; acetonitrile / 5 h / 20 °C / Inert atmosphere 3: hydrogenchloride; acetic acid / water / 3 h / 20 °C
	Multi-step reaction with 3 steps 1: methanol; dichloromethane / 1 h / 20 °C 2: iodine / dichloromethane; acetonitrile / 5 h / 20 °C / Inert atmosphere 3: hydrogenchloride; acetic acid / water / 3 h / 20 °C

Reference： [1]Chizhova, N. V.; Mamardashvili, N. Zh.; Rusanov, A. I. [Russian Journal of General Chemistry, 2020, vol. 90, # 10, p. 1878 - 1883][Zh. Obshch. Khim., 2020, vol. 90, # 10, p. 1551 - 1557,7]
[2]Cavaleiro, Jose A. S.; Neves, Maria G. P. M. S.; Hewlins, Michael J. E.; Jackson, Anthony H. [Journal of the Chemical Society. Perkin transactions I, 1986, p. 575 - 580]
[3]Qin, Jingui; Wada, Tatsuo; Sasabe, Hiroyuki [Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 1992, vol. 217, p. 47 - 51]
[4]Matsumura, Mio; Tanatani, Aya; Azumaya, Isao; Masu, Hyuma; Hashizume, Daisuke; Kagechika, Hiroyuki; Muranaka, Atsuya; Uchiyama, Masanobu [Chemical Communications, 2013, vol. 49, # 23, p. 2290 - 2292]
[5]Matsumura, Mio; Tanatani, Aya; Kaneko, Tomoyo; Azumaya, Isao; Masu, Hyuma; Hashizume, Daisuke; Kagechika, Hiroyuki; Muranaka, Atsuya; Uchiyama, Masanobu [Tetrahedron, 2013, vol. 69, # 51, p. 10927 - 10932]

17
[ 2683-82-1 ]
2-vinyl-3,7,8,12,13,17,18-heptaethylporphyrin [ No CAS ]
1-(1-ethoxyethyl)-2,3,4,5,6,7,8-heptaethylporphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 47% 2: 10%	With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In chloroform for 4h; Heating;

Reference： [1]Vicente, M. Graca H.; Smith, Kevin M. [Tetrahedron, 1991, vol. 47, # 34, p. 6887 - 6894]

18
[ 2683-82-1 ]
[ 24477-51-8 ]

Yield	Reaction Conditions	Operation in experiment
73%	With hydrogen In acetic acid

Reference： [1]Kaempfen, Ulrich; Eschenmoser, Albert [Tetrahedron Letters, 1985, vol. 26, # 48, p. 5899 - 5902]

19
[ 2683-82-1 ]
[ 20910-35-4 ]

Yield	Reaction Conditions	Operation in experiment
80%	With 2,6-di-t-butyl-4-methylphenoxy magnesium iodide In diethyl ether; chloroform at 50℃; for 0.05h;
	With triethylamine; magnesium bromide

Reference： [1]Zass, Engelbert; Isenring, Hans Peter; Etter, Rolf; Eschenmoser, Albert [Helvetica Chimica Acta, 1980, vol. 63, # 4, p. 1048 - 1067]
[2]Zhou, Chengli; Diers, James R.; Bocian, David F. [Journal of Physical Chemistry B, 1997, vol. 101, # 46, p. 9635 - 9644]

20
[ 2683-82-1 ]
[ 67514-01-6 ]

Yield	Reaction Conditions	Operation in experiment
64%	With fluoro alcohol In chloroform for 0.25h; Ambient temperature; further reagents;
57%	With NH-pyrazole; dihydrogen peroxide; methyltrioxorhenium(VII) In dichloromethane; water at 20℃;

Reference： [1]Andrews, Laura E.; Bonnett, Raymond; Ridge, Richard J.; Appelman, Evan H. [Journal of the Chemical Society. Perkin transactions I, 1983, # 1, p. 103 - 107]
[2]Banerjee, Subhadeep; Zeller, Matthias; Brueckner, Christian [Journal of Organic Chemistry, 2009, vol. 74, # 11, p. 4283 - 4288]

21
[ 2683-82-1 ]
trans-(2-bromovinyl)-2,3,4,5,6,7,8-heptaethylporphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
83%	With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In 1,2-dichloro-ethane for 5h; Heating;

Reference： [1]Vicente, M. Graca H.; Smith, Kevin M. [Tetrahedron, 1991, vol. 47, # 34, p. 6887 - 6894]

22
[ 2683-82-1 ]
[ 118824-83-2 ]
[ 118793-71-8 ]
[ 118793-69-4 ]
[ 141739-89-1 ]

Yield	Reaction Conditions	Operation in experiment
1: 19% 2: 20%	With 2,3,4,5,6-pentachloro-1-fluoropyridin-1-ium trifluoromethanesulfonate In fluorobenzene at 50℃; Title compound not separated from byproducts;

Reference： [1]Naruta, Yoshinori; Tani, Fumito; Maruyama, Kazuhiro [Tetrahedron Letters, 1992, vol. 33, # 8, p. 1069 - 1072]

23
[ 2683-82-1 ]
vic-dihydroxyoctaethylchlorine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	Stage #1: 2,3,7,8,12,13,17,18-octaethyl-porphyrin With osmium(VIII) oxide at 20℃; Stage #2: With hydrogen sulfide at 20℃; Further stages.;
66.6%	With osmium(VIII) oxide In pyridine; diethyl ether; dichloromethane for 48h; Ambient temperature;
	With pyridine; osmium(VIII) oxide; hydrogen sulfide 1. ) ether, CH₂Cl₂, RT, 48 h, 2. ) ether, CH₂Cl₂, CH₃OH, 25 min; Yield given. Multistep reaction;

Reference： [1]Kunieda, Michio; Mikata, Yuji; Tamiaki, Hitoshi [Journal of Organic Chemistry, 2007, vol. 72, # 19, p. 7398 - 7401]
[2]Chang, C. K.; Sotiriou, Chariklia [Journal of Organic Chemistry, 1987, vol. 52, # 5, p. 926 - 929]
[3]Iakovides, Panos; Smith, Kevin M. [Tetrahedron, 1996, vol. 52, # 4, p. 1123 - 1148]

24
[ 2683-82-1 ]
[ 118793-70-7 ]
[ 118793-71-8 ]
[ 118793-69-4 ]
[ 141739-89-1 ]

Yield	Reaction Conditions	Operation in experiment
1: 19% 2: 20% 3: 15%	With 2,3,4,5,6-pentachloro-1-fluoropyridin-1-ium trifluoromethanesulfonate In fluorobenzene at 50℃;

Reference： [1]Naruta, Yoshinori; Tani, Fumito; Maruyama, Kazuhiro [Tetrahedron Letters, 1992, vol. 33, # 8, p. 1069 - 1072]

25
[ 50-00-0 ]
[ 159427-97-1 ]
[ 2683-82-1 ]

Yield	Reaction Conditions	Operation in experiment
17%	With oxygen; lithium chloride In dimethyl sulfoxide at 190 - 200℃; for 4h;

Reference： [1]Tang; Verkade [Journal of Organic Chemistry, 1994, vol. 59, # 25, p. 7793 - 7802]

26
[ 50-00-0 ]
[ 159427-98-2 ]
[ 2683-82-1 ]

Yield	Reaction Conditions	Operation in experiment
67%	With air; lithium chloride In dimethyl sulfoxide at 200 - 210℃; for 2h;

Reference： [1]Tang; Verkade [Journal of Organic Chemistry, 1994, vol. 59, # 25, p. 7793 - 7802]

27
[ 2683-82-1 ]
[ 333-27-7 ]
2,3,7,8,12,13,17,18-octaethyl-22,23-dimethylporphyrin monotriflate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
96%	With potassium carbonate In chloroform at 20℃;

Reference： [1]Ivanova; Nam, Dao Tkhe; Glazunov; Semeikin; Mamardashvili [Russian Journal of General Chemistry, 2012, vol. 82, # 7, p. 1272 - 1277]

Yield	Reaction Conditions	Operation in experiment
40%	With sodium In i-Amyl alcohol at 135℃; for 1.5h;

29
[ 29786-93-4 ]
[ 2683-82-1 ]
5-Butyl-2,3,7,8,12,13,17,18-octaethylporphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
50%	Stage #1: n-butyllithium; 2,3,7,8,12,13,17,18-octaethyl-porphyrin In tetrahydrofuran; cyclohexane at -70℃; for 0.25h; Stage #2: With water In tetrahydrofuran; cyclohexane for 0.0833333h; Stage #3: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In tetrahydrofuran; dichloromethane; cyclohexane for 0.333333h; Further stages.;

Reference： [1]Senge, Mathias O.; Kalisch, Werner W.; Bischoff, Ines [Chemistry - A European Journal, 2000, vol. 6, # 15, p. 2721 - 2738]

30
[ 2683-82-1 ]
[ 591-51-5 ]
[ 60188-33-2 ]

Yield	Reaction Conditions	Operation in experiment
100%	Stage #1: 2,3,7,8,12,13,17,18-octaethyl-porphyrin; phenyllithium In tetrahydrofuran; cyclohexane at 40℃; for 0.25h; Stage #2: With water In tetrahydrofuran; cyclohexane Stage #3: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In tetrahydrofuran; dichloromethane; cyclohexane for 0.0833333h; Further stages.;
100%	Stage #1: 2,3,7,8,12,13,17,18-octaethyl-porphyrin; phenyllithium In tetrahydrofuran at -40 - 20℃; Stage #2: With water In tetrahydrofuran Stage #3: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In tetrahydrofuran Further stages.;

Reference： [1]Senge, Mathias O.; Kalisch, Werner W.; Bischoff, Ines [Chemistry - A European Journal, 2000, vol. 6, # 15, p. 2721 - 2738]
[2]Senge, Mathias O.; Bischoff, Ines [Tetrahedron Letters, 2004, vol. 45, # 8, p. 1647 - 1650]

31
[ 2683-82-1 ]
(2,3,7,8,12,13,17,18-octaethylporphyrinato)nickel(II) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
100%	With bis(acetylacetonate)nickel(II) In o-xylene for 0.5h; Heating;

Reference： [1]Chen; Medforth; Smith; Alderfer; Dougherty; Pandey [Journal of Organic Chemistry, 2001, vol. 66, # 11, p. 3930 - 3939]

32
[ 29786-93-4 ]
[ 2683-82-1 ]
(1Z,4Z,9Z,15Z)-5-Butyl-2,3,7,8,12,13,17,18-octaethyl-porphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: n-butyllithium; 2,3,7,8,12,13,17,18-octaethyl-porphyrin In tetrahydrofuran; cyclohexane at -70℃; for 0.5h; Stage #2: With water-d2 In tetrahydrofuran; cyclohexane for 0.25h; Stage #3: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In tetrahydrofuran; cyclohexane for 0.333333h; Further stages.;

Reference： [1]Feng; Bischoff; Senge [Journal of Organic Chemistry, 2001, vol. 66, # 26, p. 8693 - 8700]

33
[ 29786-93-4 ]
[ 2683-82-1 ]
5-butyl-15-deutero-2,3,7,8,12,13,17,18-octaethylporphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
43%	Stage #1: n-butyllithium; 2,3,7,8,12,13,17,18-octaethyl-porphyrin In tetrahydrofuran at -70℃; for 0.25h; Stage #2: With diclazuril In tetrahydrofuran at -70℃; for 0.333333h; Stage #3: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In tetrahydrofuran at -70 - 20℃; for 0.333333h; Further stages.;

Reference： [1]Feng; Bischoff; Senge [Journal of Organic Chemistry, 2001, vol. 66, # 26, p. 8693 - 8700]

34
[ 2683-82-1 ]
2,3,7,8,12,13,17,18-octaethyl-21H,23H-porphine copper(II) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With copper diacetate In N,N-dimethyl-formamide Heating;
	With copper diacetate In ethanol; 1,2-dichloro-ethane at 80℃; for 18h;

Reference： [1]Kuvshinova; Kuz'min; Dudkina; Pukhovskaya; Semeikin; Golubchikov [Russian Journal of General Chemistry, 2002, vol. 72, # 1, p. 133 - 136]
[2]Ogata, Hiroshi; Fukuda, Takamitsu; Nakai, Katsunori; Fujimura, Yuiehi; Neya, Saburo; Stuzhin, Pavel A.; Kobayashi, Nagao [European Journal of Inorganic Chemistry, 2004, # 8, p. 1621 - 1629]

35
[ 2683-82-1 ]
cis-2,3,7,8,12,13,17,18-octaethyl-2,3-dihydroxychlorin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	Stage #1: 2,3,7,8,12,13,17,18-octaethyl-porphyrin With pyridine; osmium(VIII) oxide In diethyl ether; dichloromethane at 20℃; for 40h; Stage #2: With hydrogen sulfide In methanol; diethyl ether; dichloromethane for 0.5h;

Reference： [1]Tamiaki, Hitoshi; Kimura, Satoshi; Kimura, Tadashi [Tetrahedron, 2003, vol. 59, # 37, p. 7423 - 7435]

36
[ 62824-63-9 ]
[ 2683-82-1 ]
5-(4-aminophenyl)-2,3,7,8,12,13,17,18-octaethyl-porphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	Stage #1: LiC₆H₄-p-NH₂; 2,3,7,8,12,13,17,18-octaethyl-porphyrin In tetrahydrofuran at -40 - 20℃; Stage #2: With water In tetrahydrofuran Stage #3: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In tetrahydrofuran Further stages.;

Reference： [1]Senge, Mathias O.; Bischoff, Ines [Tetrahedron Letters, 2004, vol. 45, # 8, p. 1647 - 1650]

37
[ 22480-64-4 ]
[ 2683-82-1 ]
5-(4-bromophenyl)-2,3,7,8,12,13,17,18-octaethyl-porphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
56%	Stage #1: 4-bromophenyllithium; 2,3,7,8,12,13,17,18-octaethyl-porphyrin In tetrahydrofuran at -40 - 20℃; Stage #2: With water In tetrahydrofuran Stage #3: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In tetrahydrofuran Further stages.;

Reference： [1]Senge, Mathias O.; Bischoff, Ines [Tetrahedron Letters, 2004, vol. 45, # 8, p. 1647 - 1650]

38
[ 2683-82-1 ]
[ 54313-25-6 ]
2,3,7,8,12,13,17,18-octaethyl-5-(5-pentenyl)porphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
48%	Stage #1: 2,3,7,8,12,13,17,18-octaethyl-porphyrin; 4-penten-1-yllithium In tetrahydrofuran at -40 - 20℃; Stage #2: With water In tetrahydrofuran Stage #3: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In tetrahydrofuran Further stages.;

Reference： [1]Senge, Mathias O.; Bischoff, Ines [Tetrahedron Letters, 2004, vol. 45, # 8, p. 1647 - 1650]

39
[ 2683-82-1 ]
C₈H₅Li [ No CAS ]
2,3,7,8,12,13,17,18-octaethyl-5-(4-ethynylphenyl)porphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	Stage #1: 2,3,7,8,12,13,17,18-octaethyl-porphyrin; C₈H₅Li In tetrahydrofuran at -40 - 20℃; Stage #2: With water In tetrahydrofuran Stage #3: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In tetrahydrofuran Further stages.;

Reference： [1]Senge, Mathias O.; Bischoff, Ines [Tetrahedron Letters, 2004, vol. 45, # 8, p. 1647 - 1650]

40
[ 2683-82-1 ]
C₃₆H₄₄B₂F₂N₄O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	With boron trifluoride diethyl etherate; triethylamine In dichloromethane at 20℃; for 1h;

Reference： [1]Koehler, Thomas; Hodgson, Michael C; Seidel, Daniel; Veauthier, Jacqueline M; Meyer, Sylvie; Lynch, Vincent; Boyd, Peter D W; Brothers, Penelope J; Sessler, Jonathan L [Chemical Communications, 2004, # 9, p. 1060 - 1061]

41
[ 2683-82-1 ]
C₃₆H₄₄B₂F₄N₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
69%	With triethylamine In dichloromethane at 20℃; for 1h;

Reference： [1]Koehler, Thomas; Hodgson, Michael C; Seidel, Daniel; Veauthier, Jacqueline M; Meyer, Sylvie; Lynch, Vincent; Boyd, Peter D W; Brothers, Penelope J; Sessler, Jonathan L [Chemical Communications, 2004, # 9, p. 1060 - 1061]

42
[ 594-19-4 ]
[ 2683-82-1 ]
(14Z,19Z)-5,10-Di-tert-butyl-2,3,7,8,12,13,17,18-octaethyl-5,10,21,22-tetrahydro-porphine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ In tetrahydrofuran at -70℃;

Reference： [1]Sergeeva, Natalia N.; Senge, Mathias O. [Tetrahedron Letters, 2006, vol. 47, # 35, p. 6169 - 6172]

43
[ 2683-82-1 ]
C₃₆H₄₄N₄^(2-)*Cl^(1-)*Rh⁽³⁺⁾ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With di(rhodium)tetracarbonyl dichloride In toluene at 20℃; for 3h;

Reference： [1]Yamazaki, Shin-Ichi; Ioroi, Tsutomu; Yamada, Yusuke; Yasuda, Kazuaki; Kobayashi, Tetsuhiko [Angewandte Chemie - International Edition, 2006, vol. 45, # 19, p. 3120 - 3122]

44
[ 2683-82-1 ]
C₃₆H₄₄N₄^(2-)*OV⁽²⁺⁾ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
76%	With bis(acetylacetonate)oxovanadium In quinoline for 6h; Heating;

Reference： [1]Wong, Suk-Yu; Sun, Raymond Wai-Yin; Chung, Nancy P.-Y.; Lin, Chen-Lung; Che, Chi-Ming [Chemical Communications, 2005, # 28, p. 3544 - 3546]

45
[ 22856-30-0 ]
[ 2683-82-1 ]
C₃₆H₄₄N₄^(2-)*C₄₈H₂₄N₈^(2-)*La⁽³⁺⁾ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 2,3-dicyanonaphthalene; 2,3,7,8,12,13,17,18-octaethyl-porphyrin With 1,8-diazabicyclo[5.4.0]undec-7-ene In octanol Heating; Stage #2: With hydrazine hydrate In methanol; chloroform Further stages.;

Reference： [1]Jiang, Jianzhuang; Bian, Yongzhong; Furuya, Fumio; Liu, Wei; Choi, Michael T. M.; Kobayashi, Nagao; Li, Hung-Wing; Yang, Qingchuan; Mak, Thomas C. W.; Ng, Dennis K. P. [Chemistry - A European Journal, 2001, vol. 7, # 23, p. 5059 - 5069]

46
[ 22856-30-0 ]
[ 2683-82-1 ]
C₃₆H₄₄N₄^(2-)*C₄₈H₂₄N₈^(2-)*Pr⁽³⁺⁾ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 2,3-dicyanonaphthalene; 2,3,7,8,12,13,17,18-octaethyl-porphyrin With 1,8-diazabicyclo[5.4.0]undec-7-ene In octanol Heating; Stage #2: With hydrazine hydrate In methanol; chloroform Further stages.;

Reference： [1]Jiang, Jianzhuang; Bian, Yongzhong; Furuya, Fumio; Liu, Wei; Choi, Michael T. M.; Kobayashi, Nagao; Li, Hung-Wing; Yang, Qingchuan; Mak, Thomas C. W.; Ng, Dennis K. P. [Chemistry - A European Journal, 2001, vol. 7, # 23, p. 5059 - 5069]

47
[ 22856-30-0 ]
[ 2683-82-1 ]
C₃₆H₄₄N₄^(2-)*C₄₈H₂₄N₈^(2-)*Nd⁽³⁺⁾ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 2,3-dicyanonaphthalene; 2,3,7,8,12,13,17,18-octaethyl-porphyrin With 1,8-diazabicyclo[5.4.0]undec-7-ene In octanol Heating; Stage #2: With hydrazine hydrate In methanol; chloroform Further stages.;

Reference： [1]Jiang, Jianzhuang; Bian, Yongzhong; Furuya, Fumio; Liu, Wei; Choi, Michael T. M.; Kobayashi, Nagao; Li, Hung-Wing; Yang, Qingchuan; Mak, Thomas C. W.; Ng, Dennis K. P. [Chemistry - A European Journal, 2001, vol. 7, # 23, p. 5059 - 5069]

48
[ 22856-30-0 ]
[ 2683-82-1 ]
C₃₆H₄₄N₄^(2-)*C₄₈H₂₄N₈^(2-)*Sm⁽³⁺⁾ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 2,3-dicyanonaphthalene; 2,3,7,8,12,13,17,18-octaethyl-porphyrin With 1,8-diazabicyclo[5.4.0]undec-7-ene In octanol Heating; Stage #2: With hydrazine hydrate In methanol; chloroform Further stages.;

Reference： [1]Jiang, Jianzhuang; Bian, Yongzhong; Furuya, Fumio; Liu, Wei; Choi, Michael T. M.; Kobayashi, Nagao; Li, Hung-Wing; Yang, Qingchuan; Mak, Thomas C. W.; Ng, Dennis K. P. [Chemistry - A European Journal, 2001, vol. 7, # 23, p. 5059 - 5069]

49
[ 22856-30-0 ]
[ 2683-82-1 ]
C₃₆H₄₄N₄^(2-)*C₄₈H₂₄N₈^(2-)*Eu⁽³⁺⁾ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 2,3-dicyanonaphthalene; 2,3,7,8,12,13,17,18-octaethyl-porphyrin With 1,8-diazabicyclo[5.4.0]undec-7-ene In octanol Heating; Stage #2: With hydrazine hydrate In methanol; chloroform Further stages.;

Reference： [1]Jiang, Jianzhuang; Bian, Yongzhong; Furuya, Fumio; Liu, Wei; Choi, Michael T. M.; Kobayashi, Nagao; Li, Hung-Wing; Yang, Qingchuan; Mak, Thomas C. W.; Ng, Dennis K. P. [Chemistry - A European Journal, 2001, vol. 7, # 23, p. 5059 - 5069]

50
[ 22856-30-0 ]
[ 2683-82-1 ]
C₃₆H₄₄N₄^(2-)*C₄₈H₂₄N₈^(2-)*Gd⁽³⁺⁾ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 2,3-dicyanonaphthalene; 2,3,7,8,12,13,17,18-octaethyl-porphyrin With 1,8-diazabicyclo[5.4.0]undec-7-ene In octanol Heating; Stage #2: With hydrazine hydrate In methanol; chloroform Further stages.;

Reference： [1]Jiang, Jianzhuang; Bian, Yongzhong; Furuya, Fumio; Liu, Wei; Choi, Michael T. M.; Kobayashi, Nagao; Li, Hung-Wing; Yang, Qingchuan; Mak, Thomas C. W.; Ng, Dennis K. P. [Chemistry - A European Journal, 2001, vol. 7, # 23, p. 5059 - 5069]

51
[ 22856-30-0 ]
[ 2683-82-1 ]
C₃₆H₄₄N₄^(2-)*C₄₈H₂₄N₈^(2-)*Tb⁽³⁺⁾ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 2,3-dicyanonaphthalene; 2,3,7,8,12,13,17,18-octaethyl-porphyrin With 1,8-diazabicyclo[5.4.0]undec-7-ene In octanol Heating; Stage #2: With hydrazine hydrate In methanol; chloroform Further stages.;

Reference： [1]Jiang, Jianzhuang; Bian, Yongzhong; Furuya, Fumio; Liu, Wei; Choi, Michael T. M.; Kobayashi, Nagao; Li, Hung-Wing; Yang, Qingchuan; Mak, Thomas C. W.; Ng, Dennis K. P. [Chemistry - A European Journal, 2001, vol. 7, # 23, p. 5059 - 5069]

52
[ 22856-30-0 ]
[ 2683-82-1 ]
C₃₆H₄₄N₄^(2-)*C₄₈H₂₄N₈^(2-)*Dy⁽³⁺⁾ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 2,3-dicyanonaphthalene; 2,3,7,8,12,13,17,18-octaethyl-porphyrin With 1,8-diazabicyclo[5.4.0]undec-7-ene In octanol Heating; Stage #2: With hydrazine hydrate In methanol; chloroform Further stages.;

Reference： [1]Jiang, Jianzhuang; Bian, Yongzhong; Furuya, Fumio; Liu, Wei; Choi, Michael T. M.; Kobayashi, Nagao; Li, Hung-Wing; Yang, Qingchuan; Mak, Thomas C. W.; Ng, Dennis K. P. [Chemistry - A European Journal, 2001, vol. 7, # 23, p. 5059 - 5069]

53
[ 22856-30-0 ]
[ 2683-82-1 ]
C₃₆H₄₄N₄^(2-)*C₄₈H₂₄N₈^(2-)*Y⁽³⁺⁾ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 2,3-dicyanonaphthalene; 2,3,7,8,12,13,17,18-octaethyl-porphyrin With 1,8-diazabicyclo[5.4.0]undec-7-ene In octanol Heating; Stage #2: With hydrazine hydrate In methanol; chloroform Further stages.;

Reference： [1]Jiang, Jianzhuang; Bian, Yongzhong; Furuya, Fumio; Liu, Wei; Choi, Michael T. M.; Kobayashi, Nagao; Li, Hung-Wing; Yang, Qingchuan; Mak, Thomas C. W.; Ng, Dennis K. P. [Chemistry - A European Journal, 2001, vol. 7, # 23, p. 5059 - 5069]

54
[ 22856-30-0 ]
[ 2683-82-1 ]
C₃₆H₄₄N₄^(2-)*C₄₈H₂₄N₈^(2-)*Ho⁽³⁺⁾ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 2,3-dicyanonaphthalene; 2,3,7,8,12,13,17,18-octaethyl-porphyrin With 1,8-diazabicyclo[5.4.0]undec-7-ene In octanol Heating; Stage #2: With hydrazine hydrate In methanol; chloroform Further stages.;

Reference： [1]Jiang, Jianzhuang; Bian, Yongzhong; Furuya, Fumio; Liu, Wei; Choi, Michael T. M.; Kobayashi, Nagao; Li, Hung-Wing; Yang, Qingchuan; Mak, Thomas C. W.; Ng, Dennis K. P. [Chemistry - A European Journal, 2001, vol. 7, # 23, p. 5059 - 5069]

55
[ 22856-30-0 ]
[ 2683-82-1 ]
C₃₆H₄₄N₄^(2-)*C₄₈H₂₄N₈^(2-)*Er⁽³⁺⁾ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 2,3-dicyanonaphthalene; 2,3,7,8,12,13,17,18-octaethyl-porphyrin With 1,8-diazabicyclo[5.4.0]undec-7-ene In octanol Heating; Stage #2: With hydrazine hydrate In methanol; chloroform Further stages.;

Reference： [1]Jiang, Jianzhuang; Bian, Yongzhong; Furuya, Fumio; Liu, Wei; Choi, Michael T. M.; Kobayashi, Nagao; Li, Hung-Wing; Yang, Qingchuan; Mak, Thomas C. W.; Ng, Dennis K. P. [Chemistry - A European Journal, 2001, vol. 7, # 23, p. 5059 - 5069]

56
[ 22856-30-0 ]
[ 2683-82-1 ]
C₃₆H₄₄N₄^(2-)*C₄₈H₂₄N₈^(2-)*Tm⁽³⁺⁾ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 2,3-dicyanonaphthalene; 2,3,7,8,12,13,17,18-octaethyl-porphyrin With 1,8-diazabicyclo[5.4.0]undec-7-ene In octanol Heating; Stage #2: With hydrazine hydrate In methanol; chloroform Further stages.;

Reference： [1]Jiang, Jianzhuang; Bian, Yongzhong; Furuya, Fumio; Liu, Wei; Choi, Michael T. M.; Kobayashi, Nagao; Li, Hung-Wing; Yang, Qingchuan; Mak, Thomas C. W.; Ng, Dennis K. P. [Chemistry - A European Journal, 2001, vol. 7, # 23, p. 5059 - 5069]

57
[ 22856-30-0 ]
[ 2683-82-1 ]
C₃₆H₄₄N₄^(2-)*C₄₈H₂₄N₈^(2-)*Yb⁽³⁺⁾ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 2,3-dicyanonaphthalene; 2,3,7,8,12,13,17,18-octaethyl-porphyrin With 1,8-diazabicyclo[5.4.0]undec-7-ene In octanol Heating; Stage #2: With hydrazine hydrate In methanol; chloroform Further stages.;

Reference： [1]Jiang, Jianzhuang; Bian, Yongzhong; Furuya, Fumio; Liu, Wei; Choi, Michael T. M.; Kobayashi, Nagao; Li, Hung-Wing; Yang, Qingchuan; Mak, Thomas C. W.; Ng, Dennis K. P. [Chemistry - A European Journal, 2001, vol. 7, # 23, p. 5059 - 5069]

58
[ 22856-30-0 ]
[ 2683-82-1 ]
C₃₆H₄₄N₄^(2-)*C₄₈H₂₄N₈^(2-)*Lu⁽³⁺⁾ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 2,3-dicyanonaphthalene; 2,3,7,8,12,13,17,18-octaethyl-porphyrin With 1,8-diazabicyclo[5.4.0]undec-7-ene In octanol Heating; Stage #2: With hydrazine hydrate In methanol; chloroform Further stages.;

Reference： [1]Jiang, Jianzhuang; Bian, Yongzhong; Furuya, Fumio; Liu, Wei; Choi, Michael T. M.; Kobayashi, Nagao; Li, Hung-Wing; Yang, Qingchuan; Mak, Thomas C. W.; Ng, Dennis K. P. [Chemistry - A European Journal, 2001, vol. 7, # 23, p. 5059 - 5069]

59
[ 22856-30-0 ]
[ 2683-82-1 ]
(2,3-naphthalocyaninato)-bis(octaethylporphyrinato)dineodymium(III) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
15 mg	Stage #1: 2,3-dicyanonaphthalene; 2,3,7,8,12,13,17,18-octaethyl-porphyrin With 1,8-diazabicyclo[5.4.0]undec-7-ene In octanol Heating; Stage #2: 2,3,7,8,12,13,17,18-octaethyl-porphyrin for 18h; Heating; Further stages.;

Reference： [1]Jiang, Jianzhuang; Bian, Yongzhong; Furuya, Fumio; Liu, Wei; Choi, Michael T. M.; Kobayashi, Nagao; Li, Hung-Wing; Yang, Qingchuan; Mak, Thomas C. W.; Ng, Dennis K. P. [Chemistry - A European Journal, 2001, vol. 7, # 23, p. 5059 - 5069]

60
[ 22856-30-0 ]
[ 2683-82-1 ]
(2,3-naphthalocyaninato)-bis(octaethylporphyrinato)dieuropium(III) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
21 mg	Stage #1: 2,3-dicyanonaphthalene; 2,3,7,8,12,13,17,18-octaethyl-porphyrin With 1,8-diazabicyclo[5.4.0]undec-7-ene In octanol Heating; Stage #2: 2,3,7,8,12,13,17,18-octaethyl-porphyrin for 18h; Heating; Further stages.;

Reference： [1]Jiang, Jianzhuang; Bian, Yongzhong; Furuya, Fumio; Liu, Wei; Choi, Michael T. M.; Kobayashi, Nagao; Li, Hung-Wing; Yang, Qingchuan; Mak, Thomas C. W.; Ng, Dennis K. P. [Chemistry - A European Journal, 2001, vol. 7, # 23, p. 5059 - 5069]

61
[ 594-19-4 ]
[ 2683-82-1 ]
5,10-di(tert-butyl)-2,3,7,8,12,13,17,18-octaethyl-5,10-dihydroporphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	With copper(l) iodide In tetrahydrofuran; pentane at -70℃;

Reference： [1]Sergeeva, Natalia N.; Shaker, Yasser M.; Finnigan, Eimear M.; McCabe, Thomas; Senge, Mathias O. [Tetrahedron, 2007, vol. 63, # 50, p. 12454 - 12464]

62
[ 2683-82-1 ]
2-acetyl-3,7,8,12,13,17,18-heptaethylporphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: osmium tetraoxide; pyridine / CH₂Cl₂; diethyl ether / 40 h / 20 °C 1.2: 82 percent / hydrogen sulfide / CH₂Cl₂; methanol; diethyl ether / 0.5 h 2.1: 48 percent / aqueous HCl / tetrahydrofuran / 1 h / Heating 3.1: 85 percent / 4-methylmorpholine N-oxide / Pr₄NRuO₄ / CH₂Cl₂ / 1.5 h / 20 °C

Reference： [1]Tamiaki, Hitoshi; Kimura, Satoshi; Kimura, Tadashi [Tetrahedron, 2003, vol. 59, # 37, p. 7423 - 7435]

63
[ 2683-82-1 ]
2-acetyl-3,7,8,12,17,18-hexaethyl-13-vinylporphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: osmium tetraoxide; pyridine / CH₂Cl₂; diethyl ether / 40 h / 20 °C 1.2: 82 percent / hydrogen sulfide / CH₂Cl₂; methanol; diethyl ether / 0.5 h 2.1: 48 percent / aqueous HCl / tetrahydrofuran / 1 h / Heating 3.1: 85 percent / 4-methylmorpholine N-oxide / Pr₄NRuO₄ / CH₂Cl₂ / 1.5 h / 20 °C 4.1: osmium tetraoxide; pyridine / CH₂Cl₂; diethyl ether / 15 h / 20 °C 4.2: 76 percent / hydrogen sulfide / CH₂Cl₂; methanol; diethyl ether 5.1: aq. HCl / benzene / Heating

Reference： [1]Tamiaki, Hitoshi; Kimura, Satoshi; Kimura, Tadashi [Tetrahedron, 2003, vol. 59, # 37, p. 7423 - 7435]

64
[ 2683-82-1 ]
2-acetyl-3,7,8,13,17,18-hexaethyl-12-formylporphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: osmium tetraoxide; pyridine / CH₂Cl₂; diethyl ether / 40 h / 20 °C 1.2: 82 percent / hydrogen sulfide / CH₂Cl₂; methanol; diethyl ether / 0.5 h 2.1: 48 percent / aqueous HCl / tetrahydrofuran / 1 h / Heating 3.1: 85 percent / 4-methylmorpholine N-oxide / Pr₄NRuO₄ / CH₂Cl₂ / 1.5 h / 20 °C 4.1: osmium tetraoxide; pyridine / CH₂Cl₂; diethyl ether / 15 h / 20 °C 4.2: 76 percent / hydrogen sulfide / CH₂Cl₂; methanol; diethyl ether 5.1: aq. HCl / benzene / Heating 5.2: osmium tetraoxide; sodium periodate; acetic acid / tetrahydrofuran; H₂O / 0 - 20 °C

Reference： [1]Tamiaki, Hitoshi; Kimura, Satoshi; Kimura, Tadashi [Tetrahedron, 2003, vol. 59, # 37, p. 7423 - 7435]

65
[ 2683-82-1 ]
2-acetyl-3,7,8,13,17,18-hexaethyl-12-vinylporphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: osmium tetraoxide; pyridine / CH₂Cl₂; diethyl ether / 40 h / 20 °C 1.2: 82 percent / hydrogen sulfide / CH₂Cl₂; methanol; diethyl ether / 0.5 h 2.1: 48 percent / aqueous HCl / tetrahydrofuran / 1 h / Heating 3.1: 85 percent / 4-methylmorpholine N-oxide / Pr₄NRuO₄ / CH₂Cl₂ / 1.5 h / 20 °C 4.1: osmium tetraoxide; pyridine / CH₂Cl₂; diethyl ether / 15 h / 20 °C 4.2: 76 percent / hydrogen sulfide / CH₂Cl₂; methanol; diethyl ether 5.1: aq. HCl / benzene / Heating

Reference： [1]Tamiaki, Hitoshi; Kimura, Satoshi; Kimura, Tadashi [Tetrahedron, 2003, vol. 59, # 37, p. 7423 - 7435]

66
[ 2683-82-1 ]
2-acetyl-3,7,8,12,17,18-hexaethyl-13-formylporphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: osmium tetraoxide; pyridine / CH₂Cl₂; diethyl ether / 40 h / 20 °C 1.2: 82 percent / hydrogen sulfide / CH₂Cl₂; methanol; diethyl ether / 0.5 h 2.1: 48 percent / aqueous HCl / tetrahydrofuran / 1 h / Heating 3.1: 85 percent / 4-methylmorpholine N-oxide / Pr₄NRuO₄ / CH₂Cl₂ / 1.5 h / 20 °C 4.1: osmium tetraoxide; pyridine / CH₂Cl₂; diethyl ether / 15 h / 20 °C 4.2: 76 percent / hydrogen sulfide / CH₂Cl₂; methanol; diethyl ether 5.1: aq. HCl / benzene / Heating 5.2: osmium tetraoxide; sodium periodate; acetic acid / tetrahydrofuran; H₂O / 0 - 20 °C

Reference： [1]Tamiaki, Hitoshi; Kimura, Satoshi; Kimura, Tadashi [Tetrahedron, 2003, vol. 59, # 37, p. 7423 - 7435]

67
[ 2683-82-1 ]
2-acetyl-3,7,8,13,17,18-hexaethyl-12-(hydroxymethyl)porphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: osmium tetraoxide; pyridine / CH₂Cl₂; diethyl ether / 40 h / 20 °C 1.2: 82 percent / hydrogen sulfide / CH₂Cl₂; methanol; diethyl ether / 0.5 h 2.1: 48 percent / aqueous HCl / tetrahydrofuran / 1 h / Heating 3.1: 85 percent / 4-methylmorpholine N-oxide / Pr₄NRuO₄ / CH₂Cl₂ / 1.5 h / 20 °C 4.1: osmium tetraoxide; pyridine / CH₂Cl₂; diethyl ether / 15 h / 20 °C 4.2: 76 percent / hydrogen sulfide / CH₂Cl₂; methanol; diethyl ether 5.1: aq. HCl / benzene / Heating 5.2: osmium tetraoxide; sodium periodate; acetic acid / tetrahydrofuran; H₂O / 0 - 20 °C 5.3: t-BuNH₂*BH₃ / CH₂Cl₂ / 20 °C

Reference： [1]Tamiaki, Hitoshi; Kimura, Satoshi; Kimura, Tadashi [Tetrahedron, 2003, vol. 59, # 37, p. 7423 - 7435]

68
[ 2683-82-1 ]
2-acetyl-3,7,8,12,17,18-hexaethyl-13-(hydroxymethyl)porphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: osmium tetraoxide; pyridine / CH₂Cl₂; diethyl ether / 40 h / 20 °C 1.2: 82 percent / hydrogen sulfide / CH₂Cl₂; methanol; diethyl ether / 0.5 h 2.1: 48 percent / aqueous HCl / tetrahydrofuran / 1 h / Heating 3.1: 85 percent / 4-methylmorpholine N-oxide / Pr₄NRuO₄ / CH₂Cl₂ / 1.5 h / 20 °C 4.1: osmium tetraoxide; pyridine / CH₂Cl₂; diethyl ether / 15 h / 20 °C 4.2: 76 percent / hydrogen sulfide / CH₂Cl₂; methanol; diethyl ether 5.1: aq. HCl / benzene / Heating 5.2: osmium tetraoxide; sodium periodate; acetic acid / tetrahydrofuran; H₂O / 0 - 20 °C 5.3: t-BuNH₂*BH₃ / CH₂Cl₂ / 20 °C

Reference： [1]Tamiaki, Hitoshi; Kimura, Satoshi; Kimura, Tadashi [Tetrahedron, 2003, vol. 59, # 37, p. 7423 - 7435]

69
[ 2683-82-1 ]
2-acetyl-3,7,8,12,13,17,18-heptaethyl-12¹-hydroxyporphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: osmium tetraoxide; pyridine / CH₂Cl₂; diethyl ether / 40 h / 20 °C 1.2: 82 percent / hydrogen sulfide / CH₂Cl₂; methanol; diethyl ether / 0.5 h 2.1: 48 percent / aqueous HCl / tetrahydrofuran / 1 h / Heating 3.1: 85 percent / 4-methylmorpholine N-oxide / Pr₄NRuO₄ / CH₂Cl₂ / 1.5 h / 20 °C 4.1: osmium tetraoxide; pyridine / CH₂Cl₂; diethyl ether / 15 h / 20 °C 4.2: 76 percent / hydrogen sulfide / CH₂Cl₂; methanol; diethyl ether 5.1: aqueous HCl / tetrahydrofuran / Heating

Reference： [1]Tamiaki, Hitoshi; Kimura, Satoshi; Kimura, Tadashi [Tetrahedron, 2003, vol. 59, # 37, p. 7423 - 7435]

70
[ 2683-82-1 ]
2-acetyl-3,7,8,12,13,17,18-heptaethyl-13¹-hydroxyporphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: osmium tetraoxide; pyridine / CH₂Cl₂; diethyl ether / 40 h / 20 °C 1.2: 82 percent / hydrogen sulfide / CH₂Cl₂; methanol; diethyl ether / 0.5 h 2.1: 48 percent / aqueous HCl / tetrahydrofuran / 1 h / Heating 3.1: 85 percent / 4-methylmorpholine N-oxide / Pr₄NRuO₄ / CH₂Cl₂ / 1.5 h / 20 °C 4.1: osmium tetraoxide; pyridine / CH₂Cl₂; diethyl ether / 15 h / 20 °C 4.2: 76 percent / hydrogen sulfide / CH₂Cl₂; methanol; diethyl ether 5.1: aqueous HCl / tetrahydrofuran / Heating

Reference： [1]Tamiaki, Hitoshi; Kimura, Satoshi; Kimura, Tadashi [Tetrahedron, 2003, vol. 59, # 37, p. 7423 - 7435]

71
[ 2683-82-1 ]
2-acetyl-3,7,8,12,13,17,18-heptaethyl-12,13-dihydroxychlorin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: osmium tetraoxide; pyridine / CH₂Cl₂; diethyl ether / 40 h / 20 °C 1.2: 82 percent / hydrogen sulfide / CH₂Cl₂; methanol; diethyl ether / 0.5 h 2.1: 48 percent / aqueous HCl / tetrahydrofuran / 1 h / Heating 3.1: 85 percent / 4-methylmorpholine N-oxide / Pr₄NRuO₄ / CH₂Cl₂ / 1.5 h / 20 °C 4.1: osmium tetraoxide; pyridine / CH₂Cl₂; diethyl ether / 15 h / 20 °C 4.2: 76 percent / hydrogen sulfide / CH₂Cl₂; methanol; diethyl ether

Reference： [1]Tamiaki, Hitoshi; Kimura, Satoshi; Kimura, Tadashi [Tetrahedron, 2003, vol. 59, # 37, p. 7423 - 7435]

72
[ 16200-50-3 ]
[ 2683-82-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: Br₂, AcOH / 0.5 h 2: KOH / 4 h / Heating 3: O₂, AcOH
	Multi-step reaction with 3 steps 1: Br₂, K₂CO₃ / CH₂Cl₂; diethyl ether / 0.33 h / Ambient temperature 2: CH₂Cl₂; diethyl ether / 0.5 h / Ambient temperature 3: 1.) KOH, 2.) AcOH, O₂ / 1.) aq. EtOH, reflux, 3 h, 2.) aq. EtOH, reflux, 1.5 h

Reference： [1]Dudkina; Shatunov; Kuvshinova; Pukhovskaya; Semeikin; Golubchikov [Russian Journal of General Chemistry, 1998, vol. 68, # 12, p. 1955 - 1960]
[2]Cheng, Lingjiang; Ma, Jinshi [Organic Preparations and Procedures International, 1995, vol. 27, # 2, p. 224 - 228]

73
[ 2683-82-1 ]
C₄₀H₅₄N₄P⁽¹⁺⁾*F₆P^(1-) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: PCl₃ 2: 2.) KPF₆ / 1.) CH₂Cl₂
	Multi-step reaction with 2 steps 1: PCl₃ 2: 20 percent / KPF₆ / CH₂Cl₂

Reference： [1]Yamamoto; Nadano; Itagaki; Akiba [Russian Journal of Organic Chemistry, 1996, vol. 32, # 2, p. 260 - 264]
[2]Yamamoto, Yohsuke; Nadano, Ryo; Itagaki, Makoto; Akiba, Kin-Ya [Journal of the American Chemical Society, 1995, vol. 117, # 31, p. 8287 - 8288]

74
[ 2683-82-1 ]
C₄₂H₅₀N₄OP⁽¹⁺⁾*Cl^(1-) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 1.) 2,6-dimethylpyridine, 2.) air / 1.) CH₂Cl₂, RT 2: aq. HCl / CH₂Cl₂

Reference： [1]Yamamoto, Yohsuke; Nadano, Ryo; Itagaki, Makoto; Akiba, Kin-Ya [Journal of the American Chemical Society, 1995, vol. 117, # 31, p. 8287 - 8288]

75
[ 3750-83-2 ]
[ 2683-82-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 100 percent / P(MeNCH₂CH₂)3N / tetrahydrofuran; propan-2-ol / 2 h / -20 - -15 °C 2: 17 percent / aq. LiCl, O₂ / dimethylsulfoxide / 4 h / 190 - 200 °C
	Multi-step reaction with 3 steps 1: 100 percent / P(MeNCH₂CH₂)3N / tetrahydrofuran; propan-2-ol / 2 h / -20 - -15 °C 2: 87.5 percent / conc. aq. HCl / ethanol / 0.5 h / Heating 3: 67 percent / aq. LiCl, air / dimethylsulfoxide / 2 h / 200 - 210 °C
	Multi-step reaction with 3 steps 1: 86 percent / DBU / tetrahydrofuran / 12 h / 20 °C 2: LiAlH₄ / tetrahydrofuran / 2 h / 0 - 5 °C 3: 1) methylal, p-TsOH, 2) chloranil / 1) CH₂Cl₂, rt, 12 h

	Multi-step reaction with 2 steps 1: 86 percent / DBU / tetrahydrofuran / 12 h / 20 °C 2: multistep reaction, a new porphyrin synthesis, other pyrrols
	Multi-step reaction with 3 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene / isopropyl alcohol; tetrahydrofuran / 4 h / 20 - 30 °C 2: sodium hydroxide / ethylene glycol / 1 h / Reflux; Inert atmosphere 3: toluene-4-sulfonic acid / benzene; water / 8 h / Dean-Stark; Reflux; Inert atmosphere

Reference： [1]Tang; Verkade [Journal of Organic Chemistry, 1994, vol. 59, # 25, p. 7793 - 7802]
[2]Tang; Verkade [Journal of Organic Chemistry, 1994, vol. 59, # 25, p. 7793 - 7802]
[3]Ono, Noboru; Kawamura, Hisayuki; Bougauchi, Masahiro; Maruyama, Kazuhiro [Tetrahedron, 1990, vol. 46, # 21, p. 7483 - 7496]
[4]Ono, Noboru; Kawamura, Hisayuki; Bougauchi, Masahiro; Maruyama, Kazuhiro [Tetrahedron, 1990, vol. 46, # 21, p. 7483 - 7496]
[5]Sessler, Jonathan L.; Mozaffari, Azadeh; Johnson, Martin R. [Organic Syntheses, 1992, vol. 70, p. 68 - 68]

76
[ 159427-97-1 ]
[ 2683-82-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 87.5 percent / conc. aq. HCl / ethanol / 0.5 h / Heating 2: 67 percent / aq. LiCl, air / dimethylsulfoxide / 2 h / 200 - 210 °C

Reference： [1]Tang; Verkade [Journal of Organic Chemistry, 1994, vol. 59, # 25, p. 7793 - 7802]

77
[ 2683-82-1 ]
[ 7718-98-1 ]
vanadyl octaethylporphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With ⁽¹⁸⁾O₂ In N,N-dimethyl-formamide Refluxing under (18)O2-atmosphere, 2 h.; Ppt. with cold water, washed, dissolved in CH2Cl2, chromatographed on alumina.;

Reference： [1]Y. Oliver; Czernuszewicz; Miller; Spiro [Journal of the American Chemical Society, 1988, vol. 110, # 13, p. 4150 - 4157]

78
[ 2683-82-1 ]
[ 7709-65-1 ]
[ 10006-11-8 ]

Yield	Reaction Conditions	Operation in experiment
1: 33% 2: 16%	With N-chloro-succinimide In chloroform Inert atmosphere; Reflux;
1: 10% 2: 20%	With hydrogenchloride; sodium azide In water at 20℃; for 1h;

Reference： [1]Location in patent: scheme or table Ito, Satoshi; Phong, Le Thanh; Komatsu, Takuya; Igarashi, Nagisa; Otsubo, Saika; Sakai, Yoshimasa; Ohno, Akira; Aramaki, Shinji; Tanaka, Yousuke; Uno, Hidemitsu; Oba, Toru; Hiratani, Kazuhisa [European Journal of Organic Chemistry, 2009, # 31, p. 5373 - 5382]
[2]Li, Ruoshi; Zeller, Mathias; Bruhn, Torsten; Brückner, Christian [European Journal of Organic Chemistry, 2017, vol. 2017, # 14, p. 1835 - 1842]

79
[ 766-96-1 ]
[ 2683-82-1 ]
2,3,7,8,12,13,17,18-octaethyl-5,10-bis(4-ethynylphenyl)porphyrin [ No CAS ]
2,3,7,8,12,13,17,18-octaethyl-5-(4-ethynylphenyl)porphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 72% 2: 10%	Stage #1: 4-bromo-1-ethynylbenzene With n-butyllithium In diethyl ether; hexane at -70 - 20℃; Inert atmosphere; Stage #2: 2,3,7,8,12,13,17,18-octaethyl-porphyrin In tetrahydrofuran; diethyl ether; hexane at -20 - 20℃; Inert atmosphere; Further stages;

Reference： [1]Location in patent: experimental part Senge, Mathias O.; Richter, Julia; Bischoff, Ines; Ryan, Aoife [Tetrahedron, 2010, vol. 66, # 19, p. 3508 - 3524]

80
[ 401-78-5 ]
[ 2683-82-1 ]
2,3,7,8,12,13,17,18-octaethyl-5-(3-trifluoromethyl-phenyl)porphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
64%	Stage #1: 3-bromo-1-trifluoromethylbenzene With n-butyllithium In diethyl ether; hexane at -30 - 20℃; Inert atmosphere; Stage #2: 2,3,7,8,12,13,17,18-octaethyl-porphyrin In tetrahydrofuran; diethyl ether; hexane at -30℃; for 1h; Inert atmosphere; Further stages;

Reference： [1]Location in patent: experimental part Senge, Mathias O.; Richter, Julia; Bischoff, Ines; Ryan, Aoife [Tetrahedron, 2010, vol. 66, # 19, p. 3508 - 3524]

81
[ 591-20-8 ]
[ 2683-82-1 ]
2,3,7,8,12,13,17,18-octaethyl-5-(3-hydroxyphenyl)porphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
26%	Stage #1: 3-Bromophenol With n-butyllithium In diethyl ether; hexane at -70 - 20℃; Inert atmosphere; Stage #2: 2,3,7,8,12,13,17,18-octaethyl-porphyrin In tetrahydrofuran; diethyl ether; hexane at -70 - -40℃; for 1h; Inert atmosphere; Further stages;

Reference： [1]Location in patent: experimental part Senge, Mathias O.; Richter, Julia; Bischoff, Ines; Ryan, Aoife [Tetrahedron, 2010, vol. 66, # 19, p. 3508 - 3524]

82
[ 580-13-2 ]
[ 2683-82-1 ]
2,3,7,8,12,13,17,18-octaethyl-5-(2-naphthyl)porphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
31%	Stage #1: 2-bromonaphthalene With n-butyllithium In diethyl ether; hexane at -50 - 20℃; Inert atmosphere; Stage #2: 2,3,7,8,12,13,17,18-octaethyl-porphyrin In tetrahydrofuran; diethyl ether; hexane at -50℃; for 1h; Inert atmosphere; Further stages;

Reference： [1]Location in patent: experimental part Senge, Mathias O.; Richter, Julia; Bischoff, Ines; Ryan, Aoife [Tetrahedron, 2010, vol. 66, # 19, p. 3508 - 3524]

83
[ 573-17-1 ]
[ 2683-82-1 ]
2,3,7,8,12,13,17,18-octaethyl-5-(phenanthren-9-yl)porphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
89%	Stage #1: 9-bromophenanthrene With n-butyllithium In diethyl ether; hexane at -30 - 20℃; Inert atmosphere; Stage #2: 2,3,7,8,12,13,17,18-octaethyl-porphyrin In tetrahydrofuran; diethyl ether; hexane at -20℃; for 1h; Inert atmosphere; Further stages;

Reference： [1]Location in patent: experimental part Senge, Mathias O.; Richter, Julia; Bischoff, Ines; Ryan, Aoife [Tetrahedron, 2010, vol. 66, # 19, p. 3508 - 3524]

84
[ 2051-98-1 ]
[ 2683-82-1 ]
5-(acenaphth-5-yl)-2,3,7,8,12,13,17,18-octaethylporphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
26%	Stage #1: 5-bromoacenaphthene With n-butyllithium In diethyl ether; hexane at -60 - 20℃; Inert atmosphere; Stage #2: 2,3,7,8,12,13,17,18-octaethyl-porphyrin In tetrahydrofuran; diethyl ether; hexane at -20℃; for 1h; Inert atmosphere; Further stages;

Reference： [1]Location in patent: experimental part Senge, Mathias O.; Richter, Julia; Bischoff, Ines; Ryan, Aoife [Tetrahedron, 2010, vol. 66, # 19, p. 3508 - 3524]

85
[ 106-38-7 ]
[ 2683-82-1 ]
[ 65858-40-4 ]

Yield	Reaction Conditions	Operation in experiment
20%	Stage #1: para-bromotoluene With n-butyllithium In diethyl ether; hexane at -10 - 20℃; Inert atmosphere; Stage #2: 2,3,7,8,12,13,17,18-octaethyl-porphyrin In tetrahydrofuran; diethyl ether; hexane at -10 - 0℃; for 1h; Inert atmosphere; Further stages;

Reference： [1]Location in patent: experimental part Senge, Mathias O.; Richter, Julia; Bischoff, Ines; Ryan, Aoife [Tetrahedron, 2010, vol. 66, # 19, p. 3508 - 3524]

86
[ 106-37-6 ]
[ 2683-82-1 ]
5-(4-bromophenyl)-2,3,7,8,12,13,17,18-octaethyl-porphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
56%	Stage #1: 1.4-dibromobenzene With n-butyllithium In tetrahydrofuran at -80 - 20℃; for 1h; Inert atmosphere; Stage #2: 2,3,7,8,12,13,17,18-octaethyl-porphyrin In tetrahydrofuran at 0 - 20℃; Inert atmosphere; Further stages;

Reference： [1]Location in patent: experimental part Senge, Mathias O.; Richter, Julia; Bischoff, Ines; Ryan, Aoife [Tetrahedron, 2010, vol. 66, # 19, p. 3508 - 3524]

87
[ 90-11-9 ]
[ 2683-82-1 ]
[ 65858-41-5 ]
2,3,7,8,12,13,17,18-octaethyl-5,10,15-tris(1-naphthyl)porphyrin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 46% 2: 1%	Stage #1: 1-Bromonaphthalene With n-butyllithium In diethyl ether; hexane at -30 - 20℃; Inert atmosphere; Stage #2: 2,3,7,8,12,13,17,18-octaethyl-porphyrin In tetrahydrofuran; diethyl ether; hexane at -30℃; for 24h; Inert atmosphere; Further stages;

Reference： [1]Location in patent: experimental part Senge, Mathias O.; Richter, Julia; Bischoff, Ines; Ryan, Aoife [Tetrahedron, 2010, vol. 66, # 19, p. 3508 - 3524]

88
[ 51554-95-1 ]
[ 2683-82-1 ]
2,3,7,8,12,13,17,18-octaethyl-5-(4-pentylphenyl)porphyrin [ No CAS ]

Reference： [1]Tetrahedron,2010,vol. 66,p. 3508 - 3524

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

CAS No. :	2683-82-1	MDL No. :	MFCD00009627
Formula :	C₃₆H₄₆N₄	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	XFIIGRBIXXECHR-UHFFFAOYSA-N
M.W :	534.78	Pubchem ID :	102311
Synonyms :

Num. heavy atoms :	40
Num. arom. heavy atoms :	10
Fraction Csp3 :	0.44
Num. rotatable bonds :	8
Num. H-bond acceptors :	2.0
Num. H-bond donors :	2.0
Molar Refractivity :	183.07
TPSA :	56.3 Å²

GI absorption :	High
BBB permeant :	No
P-gp substrate :	Yes
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-3.54 cm/s

Log Po/w (iLOGP) :	5.61
Log Po/w (XLOGP3) :	8.48
Log Po/w (WLOGP) :	6.71
Log Po/w (MLOGP) :	4.39
Log Po/w (SILICOS-IT) :	11.5
Consensus Log Po/w :	7.34

[ CAS No. 2683-82-1 ] {[proInfo.proName]}

Quality Control of [ 2683-82-1 ]

Related Doc. of [ 2683-82-1 ]

Product Details of [ 2683-82-1 ]

Calculated chemistry of [ 2683-82-1 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 2683-82-1 ]

Application In Synthesis of [ 2683-82-1 ]

[ 2683-82-1 ] Synthesis Path-Downstream 1~88

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Lipinski :	2.0
Ghose :	None
Veber :	0.0
Egan :	1.0
Muegge :	1.0
Bioavailability Score :	0.17

Log S (ESOL) :	-8.16
Solubility :	0.00000374 mg/ml ; 0.000000007 mol/l
Class :	Poorly soluble
Log S (Ali) :	-9.53
Solubility :	0.000000157 mg/ml ; 0.0000000003 mol/l
Class :	Poorly soluble
Log S (SILICOS-IT) :	-11.82
Solubility :	0.0000000008 mg/ml ; 0.0 mol/l
Class :	Insoluble

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	3.0
Synthetic accessibility :	7.8

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling