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Chemical Structure| 261951-78-4 Chemical Structure| 261951-78-4

Structure of 261951-78-4

Chemical Structure| 261951-78-4

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Product Details of [ 261951-78-4 ]

CAS No. :261951-78-4
Formula : C8H6F4O
M.W : 194.13
SMILES Code : COC1=C(F)C=CC(=C1)C(F)(F)F
MDL No. :MFCD01631564

Safety of [ 261951-78-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H227-H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P370+P378-P403+P233-P501

Application In Synthesis of [ 261951-78-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 261951-78-4 ]

[ 261951-78-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 141483-15-0 ]
  • [ 74-88-4 ]
  • [ 261951-78-4 ]
YieldReaction ConditionsOperation in experiment
60 % sodium hydride (35 mg) was added into the DMF (3 ml) solution of 4-fluoro 3-hydroxybenzotrifluoride (0.17 g) with chilling on ice. After its mixture was stirred for 20 minutes, iodomethane (0.11 g) was added into it, and was then heated at 60 C with stirring for 40 minutes. After the mixture was cooled to room temperature, the chemical compound (19) (0.22 g) and 60 % sodium hydride (35 mg) were added to it at room temperature, followed by heating at 100 C over night. After the mixture was cooled to room temperature, it was poured into ice-water, and was then subjected to extraction with ethyl acetate. After its organic layer was washed with water, and was then dried with anhydrous magnesium sulfate, it was filtered, and was then concentrated under reduced pressure. Its residue was purified by column chromatography to produce the chemical compound mentioned in the above title (0.18 g). Viscous oil. 1H NMR (CDCl3) delta 2.00-2.22 (m,6H), 2.38-2.44 (m,2H), 3.90 (s,3H), 4.56-4.61 (m,3H), 6.56 (d,1H), 6.77 (d,1H), 7.10 (s,1H), 7.16 (d,1H), 7.60 (dd,1H), 8.40 (brd, 1H)
 

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