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Chemical Structure| 259807-46-0 Chemical Structure| 259807-46-0

Structure of 259807-46-0

Chemical Structure| 259807-46-0

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Product Details of [ 259807-46-0 ]

CAS No. :259807-46-0
Formula : C12H11N3O2
M.W : 229.24
SMILES Code : O=C(C1=CN=C(C2=CC=NC=C2)N=C1)OCC
MDL No. :MFCD09863216

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Application In Synthesis of [ 259807-46-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 259807-46-0 ]

[ 259807-46-0 ] Synthesis Path-Downstream   1~2

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  • [ 80370-42-9 ]
  • [ 33278-46-5 ]
  • [ 259807-46-0 ]
  • 2
  • [ 80370-42-9 ]
  • [ 6345-27-3 ]
  • [ 259807-46-0 ]
YieldReaction ConditionsOperation in experiment
15% With sodium ethanolate; In ethanol; for 6h;Heating / reflux; At room temperature, sodium ethoxide (590 mg) was dissolved in anhydrous ethanol (50 ml). 4-Amidinopyridine hydrochloride (1.31 g) was added to the resulting solution. After an anhydrous ethanol solution (ethanol: 50 ml) of ethyl 2,2-diformylacetate (1.20 g) was added dropwise, the resulting mixture was heated under reflux for 6 hours. Dichloromethane and water were added to the residue obtained by distilling off the solvent under reduced pressure. The organic layer thus separated was dried over anhydrous sodium sulfate. After the solvent was concentrated under reduced pressure, the residue was crystallized in ethanol, whereby the title compound (279 mg, 15percent) was obtained as colorless crystals.1H-NMR (DMSO-d6) delta: 1.46(3H,t,J=7.3Hz), 4.48 (2H, q, J=7.3Hz), 8.35 (2H, d, J=5.9Hz), 8.82(2H,d,J=5.9Hz), 9.38(2H,s). MS (FAB)m/z: 230(M+H)+.
 

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