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Chemical Structure| 251366-35-5 Chemical Structure| 251366-35-5

Structure of 251366-35-5

Chemical Structure| 251366-35-5

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Product Details of [ 251366-35-5 ]

CAS No. :251366-35-5
Formula : C12H6ClF2NO
M.W : 253.63
SMILES Code : O=C(C1=CN=C(Cl)C=C1)C2=CC=CC(F)=C2F
MDL No. :MFCD13153372

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Application In Synthesis of [ 251366-35-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 251366-35-5 ]

[ 251366-35-5 ] Synthesis Path-Downstream   1~1

  • 1
  • 6-Chloro-N-methoxy-N-methyl-nicotinamide [ No CAS ]
  • [ 38573-88-5 ]
  • [ 251366-35-5 ]
YieldReaction ConditionsOperation in experiment
130 mg (77%) With n-butyllithium; ammonium chloride; In tetrahydrofuran; hexane; ethyl acetate; Preparation 149 2-Chloro-5-(2,3-difluorobenzoyl)pyridine To a solution of <strong>[38573-88-5]1-<strong>[38573-88-5]bromo-2,3-difluorobenzene</strong></strong> (0.114 g, 0.746 mmol) in 3 ml of dry THF was added, at -78° C., n-butyl lithium (1.6 M in hexane, 0.47 ml, 0.749 mmol). The reaction mixture was stirred at this temperature for 1 hour. A solution of 6-chloro-N-methoxy-N-methyl-nicotinamide (0.13 g, 0.68 mmol) in 5 ml of THF was added and the reaction mixture was allowed to warm to RT and stir for 6 hours. Saturated NH4Cl was added and the mixture was extracted with CH2Cl2 (3*10 ml). The organic layers were combined, washed with brine, and dried over NaSO4. The solvents were removed in vacuo and the residue was purified by column chromatography (Hex/AcOEt 9:1) to give 130 mg (77percent) of an oily product. IR, NMR.
 

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