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CAS No. : | 23814-14-4 | MDL No. : | MFCD01233165 |
Formula : | C8H6N2O3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | YIGYJEWJHOCKSR-UHFFFAOYSA-N |
M.W : | 178.15 | Pubchem ID : | 780757 |
Synonyms : |
|
Num. heavy atoms : | 13 |
Num. arom. heavy atoms : | 9 |
Fraction Csp3 : | 0.0 |
Num. rotatable bonds : | 1 |
Num. H-bond acceptors : | 3.0 |
Num. H-bond donors : | 3.0 |
Molar Refractivity : | 45.88 |
TPSA : | 85.95 Ų |
GI absorption : | High |
BBB permeant : | No |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -7.32 cm/s |
Log Po/w (iLOGP) : | 0.66 |
Log Po/w (XLOGP3) : | 0.09 |
Log Po/w (WLOGP) : | 0.55 |
Log Po/w (MLOGP) : | 0.49 |
Log Po/w (SILICOS-IT) : | 1.51 |
Consensus Log Po/w : | 0.66 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -1.45 |
Solubility : | 6.36 mg/ml ; 0.0357 mol/l |
Class : | Very soluble |
Log S (Ali) : | -1.45 |
Solubility : | 6.33 mg/ml ; 0.0355 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | -2.19 |
Solubility : | 1.15 mg/ml ; 0.00646 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.38 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
73.6% | With benzotriazol-1-ol; diisopropyl-carbodiimide; In DMF (N,N-dimethyl-formamide); at 20℃; for 16h; | C) 2-Oxo-2, 3-dihydro-lH-benzoimidazolyl-5-carboxyl (I-N-3, 4- dibenzyloxy phenyl) amide; 1, 3- N, N-Diisopropylcarbodiimde (0.412 g; 3.27 mmol) was added to a solution of 2-oxo-2, 3-dihydro-1H-benzoimidazole-5-carboxylic acid (0.584 g; 3.27 mmol) 3,4-dibenzyloxy aniline (1.0 g, 3.27 mmol) and 1-hydroxybenzotriazole (0.442 g, 3.27 mmol) in anhydrous N, N - dimethylformamide (15 ml). After stirring for 16 hrs at room temperature the reaction mixture was poured in water (150 ml). The pH of the mixture was adjusted to 2 with IN hydrochloric acid and stirred for 30 minutes. Filtration and washing the product with ethyl acetate (3 x 10 ml) provided 1.12 grams of 2-Oxo-2, 3-dihydro-l H-benzoimidazolyl-5-carboxyl (1-N-3, 4-dibenzyloxy phenyl) amide. Yield = 73.6 %. ¹H NMR (CD3)2SO 10.5 (1H, s, NH) 7.65 (1H, d, J 8Hz) 7.6 (1H, s) 7.2-7.6 (m, 12H) 7.0 (2H, d, J 8Hz) 5.15 (4H, s). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
28% | With benzotriazol-1-ol; diisopropyl-carbodiimide; In DMF (N,N-dimethyl-formamide); at 40℃; for 12h; | Example 9; 2-Oxo-N-(2-oxo-2,3-dihydro-1 H-benzo [d] imidazol-5-yl)-2,3-dihydro-1 H- benzo[d]imidazole-5-carboxide (referred to as DC-0051-Bl); The amide was synthesized by reacting 2-oxo-2, 3-dihydro-lH- benzoimidazolyl-5-carboxylic acid with 5-amino-2, 3-dihydro-lH-benzoimidazol-5- one in the presence of 1,3- N, N-diisopropylcarbodiimide and 1- hydroxybenzotriazole. 1,3- N, N-Diisopropylcarbodiimde (0.504 g; 4 mmol) was added to a solution of 2-oxo-2,3-dihydro-lH-benzoimidazole-5-carboxylic acid (0.448 g; 2.5 mmol), 5- amino-2-oxo-2,3-dihydro-lH-benzoimidazole and 1-hydroxybenzotriazole (0.34 g; 2.5 mmol) in anhydrous N, N-dimethylformamide (10 ml). The reaction mixture was stirred at 40 C for 12 hours. The precipitated product was isolated by filtration of the reaction mixture followed by washing three more times with N, N-dimethylformamide (3 ml). The product was dissolved in dimethylsulfoxide (5ml) and precipitated by diluting the solution with acetonitrile (60 ml). Filtration and drying under vacuum gave 2-Oxo-N-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2,3-dihydro-1H- benzo [d]imidazole-5-carboxide (also referred to as DC-0051-B1) (0.22 g; 28%). ¹H NMR ((CD3)2SO 10.62 (1H, s, NH), 10.53 (1H, s, NH), 9.98 (lH, s, NH) 7.65 (1H, d, J 8Hz) 7.55 (2H, bs) 7.23 (1H, d, J 8Hz) 7.05 (1H, d, J 8Hz) 7.85 (1H, d, J 8Hz). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
40% | With trichlorophosphate; at 90℃; for 13h; | A solution of 10 (2.50 g, 14.0 mmol) in POCl3 (20 mL, 215 mmol) was stirred at 90 C for 13 h. Thereaction was then quenched by addition of water and saturated aq. NaHCO3 at 0 C. The resultingsuspension was filtered. The residue was washed with AcOEt and purified by silica gel columnchromatography (CHCl3/MeOH = 4/1) to afford 11 (1.11 g, 40%) as a white solid.1H-NMR (500 MHz, DMSO-d6) ae 8.07 (s, 1H), 7.84 (d, J = 8.6 Hz, 1H), 7.57 (d, J = 8.6 Hz, 1H). TheNH and CO2H proton signals were not observed.; ESI-TOF-HRMS calcd for C8H4ClN2O2 (m/z) [M-H]-194.9956, found 194.9965. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
(1) A mixture of 228 mg of <strong>[23814-14-4]2-oxo-2,3-dihydro-1H-benzimidazole-5-carboxylic acid</strong>, 2.00 mL of phosphorus oxychloride, and one drop of concentrated hydrochloric acid was stirred at 100C overnight. The solvent was removed by distillation under reduced pressure. To the residue was added 4.0 mL of methanol at room temperature, followed by stirring for 1 hour. It was diluted with water and ethyl acetate, and added with potassium carbonate until it had pH 8. The insolubles were separated by filtration, and then extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure to obtain 313 mg of methyl 2-chloro-1H-benzimidazole-6-carboxylate as a pale brown solid. ESI+: 211 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
A solution of 2-oxo-2,3-dihydro-lH-benzo[d]imidazole-5-carboxylic acid (Princeton, 178 mg, 1.0 mmol) in CH2Cl2 (anhydrous, 5.0 mL) was stirred with oxalyl chloride (Aldrich, 2 M, in CH2Cl2, 1.0 mL) in the presence of 2 drops dimethylformamide at room temperature for 1 hour. It was then concentrated and dried under reduced pressure. The residue was dissolved in pyridine (5.00 mL) and then stirred with N- hydroxynicotinimidamide (Tyger, 137 mg, 1.0 mmol) at 100 0C for 16 hours. The reaction mixture was cooled to ambient temperature, diluted with EtOAc (50 mL), washed with water (2 x 10 mL) and brine. The organic solution was concentrated under reduced pressure, purified with preparative HPLC [Waters, column: Xbridge Prep C18 5mum, OBD 30 x 100 mm, solvent: acetonitrile/water(v.l% TFA), 5/95 to 95/5, flow rate of 40 mL/minute. Fractions were collected based upon UV signal threshold.] the title compound. 1H NMR (300 MHz, CD3OD) delta 7.25 (d, J=8.3 Hz, 1 H), 7.75 (ddd, J=7.9, 5.2, 0.8 Hz, 1 H), 7.88 (d, J=I.6 Hz, 1 H), 7.99 (dd, J=8.3, 1.6 Hz, 1 H), 8.68 (dt, J=7.9, 1.8 Hz, 1 H), 8.79 (dd, J=5.2, 1.6 Hz, 1 H), 9.33 (d, J=I .2 Hz, 1 H) ppm. MS (DCI/NH3) m/z 280 (M+H)+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With 1-methyl-1H-imidazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20℃; for 16h; | Example 14 N-(1-(7-(3,4-Dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)pyrrolidin-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamide Procedure: A mixture of 5-(3-aminopyrrolidin-1-yl)-N-(3,4-dimethoxyphenyl)thiazolo[5,4-d]pyrimidin-7-amine hydrochloride (100 mg, 0.245 mmol), <strong>[23814-14-4]2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxylic acid</strong> (48 mg, 0.27 mmol), EDCI (97 mg, 0.49 mmol) and N-methylimidazole (60 mg, 0.735 mmol) in 10 mL of DCM was stirred at room temperature for 16 hours. The mixture was washed with water (5 mL), The organic layer was dried over Na2SO4. After filtration and concentration, the residue was purified by column chromatography on silica gel eluting with a mixture of CH2Cl2 and methanol (100:1: to 20:1, V/V) to give N-(1-(7-(3,4-dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)pyrrolidin-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamide (25 mg, 19%) as white solid. 1H NMR (300 MHz, DMSO): delta 9.57 (s, 1H), 8.81 (s, 1H), 8.475-8.46 (m, 1H), 8.27-8.25 (m, 2H), 7.60-7.25 (m, 2H), 6.92 (d, 1H, J=8.7 Hz), 6.47-6.39 (m, 3H), 4.54-4.52 (m, 1H), 3.76-3.58 (m, 10H), 2.27-2.05 (m, 2H). LC-MS: 247 [M/2+H]+, 493 [M+H]+, 491 [M-H]-, tR=1.22 min. HPLC: 95.20% at 214 nm, 95.06% at 254 nm, tR=5.64 min. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
19% | With 1-methyl-1H-imidazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20℃; for 16h; | A mixture of 5-(3-aminopyrrolidin-l-yl)-N-(3,4-dimethoxyphenyl)thiazolo[5,4- <i]pyrimidin-7-amine hydrochloride (100 mg, 0.245 mmol), 2-oxo-2,3-dihydro- lH- benzo[d]imidazole-5-carboxylic acid (48 mg, 0.27 mmol), EDCI (97 mg, 0.49 mmol) and N-methylimidazole (60 mg, 0.735 mmol) in 10 mL of DCM was stirred at room temperature for 16 hours. The mixture was washed with water (5 mL), The organic layer was dried over Na2S04. After filtration and concentration, the residue was purified by column chromatography on silica gel eluting with a mixture of CH2C12 and methanol (100: 1 : to 20: 1, V/V) to give N-(l-(7-(3,4-dimethoxyphenylamino)thiazolo[5,4- <i]pyrimidin-5-yl)pyrrolidin-3-yl)-2-oxo-2,3-dihydro-lH-benzo[d]imidazole-5- carboxamide (25 mg, 19 %) as white solid. 1H NMR (300 MHz, DMSO): delta 9.57 (s, 1H), 8.81 (s, 1H), 8.475 - 8.46 (m, 1H), 8.27 - 8.25 (m, 2H), 7.60 - 7.25 (m, 2H), 6.92 (d, 1H, J = 8.7 Hz), 6.47 - 6.39 (m, 3H), 4.54 - 4.52 (m, 1H), 3.76 - 3.58 (m, 10H), 2.27 - 2.05 (m, 2H). LC - MS: 247 [M/2 + H]+, 493 [M + H]+, 491 [M - H]", tR = 1.22 min. HPLC: 95.20 % at 214 nm, 95.06 % at 254nm, tR = 5.64 min. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
45% | To a stirred solution of <strong>[23814-14-4]2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxylic acid</strong> (0.2 g, 0.66 mmol) in DMF (1.5 mL) was added EDCI.HCl (0.191 g, 1.00 mmol), HOBt (0.091g, 0.66 mmol) and diispropylethylamine (0.34 mL, 2.00 mmol). The solution was stirred for 10 min at 0oC. After that tert-butyl ((2S)-1-(4-(1- aminoethyl)piperidin-1-yl)-1-oxopropan-2-yl)carbamate (0.142 g, 0.80 mmol) was added and the reaction stirred at rt for 12 h. The progress of the reaction was monitored by TLC. After complete consumption of starting material, the reaction was quenched with water and extracted with ethyl acetate. The organic layer was washed with brine, dried overanhydrous Na2SO4and concentrated under reduced pressure to obtain a crude residue which was purified by column chromatography to afford tert-butyl ((2S)-1-oxo-1-(4-(1- (2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamido)ethyl)piperidin-1-yl)propan-2- yl)carbamate (0.140 g, 45%) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
2.48g | With 3-Methylpyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20℃; for 18h; | 2-Chloro-1H-indole-6-carboxylic acid (1.95 g, 10 mmol) and p-methylbenzoylhydrazone(1.5 g, 10 mmol) was suspended in 40 mL of tetrahydrofuran,Then add EDC (3.2g),HOBt (2.1g) and 3-methyl pyridine (3.5mL),After stirring for 24 hours at room temperature,filter,The cake was washed with tetrahydrofuran to give an off-white solid.After drying, 3.05 g of dihydrazide was obtained.Used in the next step without purification.With reference to the method shown in Example 1,Where "2-chloro-1H-indole-6-carboxylic acid" is replaced by 2-oxo-2,3-dihydro-1H-Benzimidazole-5-carboxylic acid.In this embodiment,2-oxo-2,3-dihydro -1H- benzimidazole-5-carboxylic acid (1.78g, 10mmol),p-Methylbenzoylhydrazone (1.5g, 10mmol),The reaction is stirred at room temperature for 18 hours.After drying, the dihydrazide compound is obtained2.48g.In step b,Burgess reagent (4.5g),Warming reflux reaction for 5 hours,Recrystallization of anhydrous ethanol gives a white solidCompound 1-2 (1.82 g), yield 78%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
44% | With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20℃; for 4h; | To a stirred solution of 2-oxo-2,3-dihydro-lH-benzo[d]imidazole-5-carboxylic acid (70 mg), l-(piperazin-l-yl)ethanone84 (50.4 mg) and N,N-diisopropylethylamine (206 mu) in DMF (1 ml) was added HATU (224 mg). The reaction mixture was stirred at room temperature for 4 h. The reaction mixture was concentrated in vacuo and the residue was purified by preparative reverse-phase HPLC (Gemini NX CI 8, 12 nm, 5mu, 100 x 30 mm, flow rate 40 ml/min, eluant: CH3CN/H2O containing formic acid) followed by lyophilisation to afford 5-(4-acetylpiperazine- l-carbonyl)-lH-benzo[d]imidazol-2(3H)-one (50 mg, 44%) as white solid. MS (ISP): 289.1 ([M+H]+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
21% | With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; at 20℃; for 4h; | To a stirred solution of 2-oxo-2,3-dihydro-lH-benzo[d]imidazole-5-carboxylic acid56 150 mg) and methyl indoline-4-carboxylate114 (149 mg) in methanol (5 ml) was added 4-(4,6- dimethoxy-l,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride 115 (280 mg, DMTMM). The reaction muxture was stirred for 4 h at room temperature. LC/MS analysis indicated that the reaction was complete. The reaction mixture was concentrated in vacuo and the residue was purified by preparative reverse-phase HPLC (Gemini NX CI 8, 12 nm, 5mu, 100 x 30 mm, flow rate 40 ml/min, eluant: CH3CN/H2O containing formic acid) followed by lyophilisation in vacuo to afford methyl l-(2-oxo-2,3-dihydro-lH-benzo[d]imidazole-5-carbonyl)indoline-4-carboxylate (60 mg, 21%) as a white solid. MS (ISP): 338.1 ([M+H]+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
8.5% | With dmap; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 25℃; for 16h; | To a solution of 4-dimethylaminopyridine (165 mg) in N,N-dimethylformamide (5 ml) were added 2-oxo-2,3-dihydro-lH-benzimidazole-5-carboxylic acid142 (200 mg), HATU (512 mg), N,N-diisopropylethylamine (0.59 ml) and l-(4-(methylamino)piperidin-l-yl)ethanone hydrochloride143 (216 mg), then the mixture was stirred at 25 C for 16 hr. The reaction mixture was diluted with ethyl acetate (5 ml) and water (10 ml). The aqueous layer was extracted twice with ethyl acetate, then the combined organic layers were dried over Na2S04 and concentrated in vacuo. The crude material was purified by preparative reversed phase HPLC to afford methyl N- (l-acetylpiperidin-4-yl)-N-methyl-2-oxo-2,3-dihydro-lH-benzo[d]imidazole-5-carboxamide (30 mg, 8.5 %) as a yellow solid. MS (ISP): 317.2 ([M+H]+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | In pentan-1-ol; for 4h;Reflux; | A solution of 3,4-diaminobenzoic acid (3.04 g, 20.0 mmol) and urea (1.44 g, 24.0 mmol) in n-pentanol(10 mL) was refluxed for 4 h, and then cooled to room temperature. Water and aq. HCl were added. Theresulting suspension was filtered, and the residue was washed with water and MeOH to afford 10 (3.26 g,92%) as a white solid. 1H-NMR (500 MHz, DMSO-d6) delta 7.59 (d, J = 8.0 Hz, 1H), 7.46 (s, 1H), 6.94 (d, J = 8.0 Hz, 1H). TheNH and CO2H proton signals were not observed.; 13C-NMR (125 MHz, DMSO-d6) delta 168.1, 155.4, 132.9,129.3, 125.4, 122.7, 109.3, 107.7; ESI-TOF-HRMS calcd for C8H5N2O3 (m/z) [M-H]- 177.0295, found177.0313. |
Tags: 23814-14-4 synthesis path| 23814-14-4 SDS| 23814-14-4 COA| 23814-14-4 purity| 23814-14-4 application| 23814-14-4 NMR| 23814-14-4 COA| 23814-14-4 structure
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P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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