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Chemical Structure| 2206-43-1 Chemical Structure| 2206-43-1

Structure of 2206-43-1

Chemical Structure| 2206-43-1

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Product Details of [ 2206-43-1 ]

CAS No. :2206-43-1
Formula : C9H8O5
M.W : 196.16
SMILES Code : COC1=CC=C(C=C1C(O)=O)C(O)=O
MDL No. :MFCD06208422
InChI Key :JIICYHFLIOGGHE-UHFFFAOYSA-N
Pubchem ID :75152

Safety of [ 2206-43-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 2206-43-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2206-43-1 ]

[ 2206-43-1 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 20628-07-3 ]
  • [ 2206-43-1 ]
YieldReaction ConditionsOperation in experiment
69.6% A mixture of compound 7 (34.2 mmol, 5.6 g) and sodium hydroxide (100.0 mmol, 4.0 g) in 200 mL of water was stirred at room temperature for 30 min. The temperature of the solution was then raised to 80C within 3 h, and potassium permanganate (170.0 mmol, 23.2 g) was added quickly in small portions. When the reaction was complete, 3 mL of ethanol was added through the top of the reflux condenser to consume unreacted KMnO4. The precipitate of manganese dioxide was separated by filtration and washed with hot water (2 × 25 mL). The filtrate was combined with the washings, acidified with dilute aqueous hydrochloric acid to pH 1-2, and cooled, and the precipitate was filtered off. The product was additionally recrystallized from ethanol Yield 4.6 g (23.5 mmol, 69.6%), white solid, mp 260-261C; published data [13]: mp 268-269C. IR spectrum, nu, cm-1: 3300 br (OH), 2955 (C-H), 1606 (C=O). 1H NMR (DMSO-d6), delta, ppm: 3.88 s (3H, OCH3), 7.20 d (1H, Harom, J = 8.8 Hz), 8.03 d.d (1H, Harom, J =8.8, 2.0 Hz), 8.21 d (1H, Harom, J = 2.0 Hz), 12.9 s (2H,COOH). 13C NMR (DMSO-d6), deltaC, ppm: 56.2, 112,5, 121,1, 122.5, 132.3, 134.4, 161.6, 166.5, 166.6. Mass spectrum: m/z 195 [M -H]-.
18 g With potassium permanganate; sodium hydroxide; In water; for 3h; Add in the round bottom bottle step product 24.0g, 20g sodium hydroxide,116g of potassium permanganate and 200mL of water,Stirring for 3h,Filter. The filtrate acidified to pH = 1 ~ 2,Crude 23.6g. Dilute ethanol recrystallization,4-methoxy-1,3-benzenedicarboxylic acid (6) 18.0 g of white crystals,Yield 62.8%mp: 268-270 C.
 

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