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Chemical Structure| 210825-11-9 Chemical Structure| 210825-11-9

Structure of 210825-11-9

Chemical Structure| 210825-11-9

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Product Details of [ 210825-11-9 ]

CAS No. :210825-11-9
Formula : C14H10N2OS
M.W : 254.31
SMILES Code : O=CC1=CN(N=C1C1=CC=CS1)C1=CC=CC=C1
MDL No. :MFCD01829483

Safety of [ 210825-11-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 210825-11-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 210825-11-9 ]

[ 210825-11-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 3321-92-4 ]
  • [ 210825-11-9 ]
  • 1-(3,5-dichloro-2-hydroxy-phenyl)-3-(1-phenyl-3-thiophen-2-yl-1<i>H</i>-pyrazol-4-yl)-propenone [ No CAS ]
  • 2
  • [ 3321-92-4 ]
  • [ 210825-11-9 ]
  • 6,8-dichloro-3-hydroxy-2-[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl]-4H-chromen-4-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
86% General procedure: II (Microwave irradiation). To a well-stirred solution of2-hydroxyacetophenones 1a-h (1 mmol) and 1-phenyl-3-(thiophen-2-yl)-1H-pyrazole-4-carbaldehyde (2) (254 mg,1 mmol) in EtOH (2 ml), a solution of NaOH (160 mg,4 mmol) in EtOH (4 ml) was added at room temperature.The reaction mixture was irradiated by microwaves at 100 Wfor 9-10 min. After consumption of reactants (as indicatedby TLC), aqueous NaOH solution (200 mg, 5 mmol in 2 mlof H2O) and 30% H2O2 (3 ml) were added dropwise andirradiation continued for 2-3 min. After completion of thereaction (monitored by TLC), the resulting light-yellowmixture was poured onto crushed ice and neutralized withdilute HCl. The light-yellow solid thus obtained was filteredoff, washed with water, and dried. The crude productwas purified by column chromatography on silica gel usinghexane-EtOAc, 7:3, as eluent and further recrystallizedfrom EtOH to afford the desired products 3a-h as yellowsolids, the respective yields are shown in Table 1.
 

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