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Chemical Structure| 210408-48-3 Chemical Structure| 210408-48-3

Structure of 210408-48-3

Chemical Structure| 210408-48-3

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Product Details of [ 210408-48-3 ]

CAS No. :210408-48-3
Formula : C9H11BrO
M.W : 215.09
SMILES Code : CC(O)CC1=CC=CC=C1Br
MDL No. :MFCD12153690

Safety of [ 210408-48-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 210408-48-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 210408-48-3 ]

[ 210408-48-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 21906-31-0 ]
  • [ 210408-48-3 ]
YieldReaction ConditionsOperation in experiment
With sodium tetrahydroborate; In methanol; at 0 - 20℃; To a solution of l -(2-bromophenyl) propane-2-one (30 g, 140 mmol)To a solution of l -(2-bromophenyl) propane-2-one (30 g, 140 mmol) in MeOH ( 100 ml) was added NaBH4 (6.09 g, 210 mmol) at 0C and stirred at room temperature for 2 h. The reaction mixture was quenched with water and concentrated under reduced pressure to afford crude compound. The title compound was purified by separation methods A, E and M (Yield 28.0 g). The enantiomer- 1 showed up at tt =7.86 min with Chiralcel OD-H (4.6X250mm) 5mu, hexane: 2-PrOH: TFA (90:5:0. 1), 1 ml/min. in MeOH ( 100 ml) was added NaBH4 (6.09 g, 210 mmol) at 0C and stirred at room temperature for 2 h. The reaction mixture was quenched with water and concentrated under reduced pressure to afford crude compound. The title compound was purified by separation methods A, E and M (Yield 28.0 g). The enantiomer- 1 showed up at tt =7.86 min with Chiralcel OD-H (4.6X250mm) 5mu, hexane: 2-PrOH: TFA (90:5:0. 1), 1 ml/min.
 

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