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Chemical Structure| 20878-54-0 Chemical Structure| 20878-54-0

Structure of 20878-54-0

Chemical Structure| 20878-54-0

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Product Details of [ 20878-54-0 ]

CAS No. :20878-54-0
Formula : C14H14N2O2
M.W : 242.27
SMILES Code : O=C(NC1=CC=C(OC)C=C1)C2=CC=CC=C2N
MDL No. :MFCD00434408
InChI Key :VOUMPTOODFUGMO-UHFFFAOYSA-N
Pubchem ID :478820

Safety of [ 20878-54-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 20878-54-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 20878-54-0 ]

[ 20878-54-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 4385-76-6 ]
  • [ 20878-54-0 ]
  • 2-[[4-(4-Pyridyl)benzoyl]amino]-N-(4-methoxyphenyl)benzamide Hydrochloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
With thionyl chloride; In pyridine; toluene; EXAMPLE 192 Preparation of 2-[[4-(4-Pyridyl)benzoyl]amino]-N-(4-methoxyphenyl)benzamide Hydrochloride To a stirring suspension of 4-(4-pyridyl)benzoic acid (0.2 g, 1 mmol) in toluene (35 mL) was added thionyl chloride (0.55 mL, 7.5 mmol) and the mixture was heated to reflux. After 1 h the solution was cooled and added to a solution of 2-amino-N-(4-methoxyphenyl)benzamide (0.176 g, 0.73 mmol) in pyridine (2 mL) and toluene (5 mL). After stirring for 48 h, the solvent was removed in vacuo and the residue was partitioned between ethyl acetate and water. The organic phase was separated and washed with sat. NaHCO3, brine and dried (MgSO4), filtered and concentrated to give 103 mg of brown solid which was chromatographed by RPHPLC Method B. Upon standing, a sample of the title compound (14 mg, 4percent) crystalized from one of the product containing fractions. 1H-NMR; MS-FD, m/e 424.2 (MH+); Analysis for C26H21N3O3.2.1HCl: Calc: C, 62.45; H, 4.66; N, 8.40; Found: C, 62.66; H, 4.01; N, 7.93.
 

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