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Chemical Structure| 204512-89-0 Chemical Structure| 204512-89-0

Structure of 204512-89-0

Chemical Structure| 204512-89-0

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Product Details of [ 204512-89-0 ]

CAS No. :204512-89-0
Formula : C14H19N5O5
M.W : 337.33
SMILES Code : OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3NC4COCC4)O1)O)O

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Application In Synthesis of [ 204512-89-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 204512-89-0 ]

[ 204512-89-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 88675-24-5 ]
  • [ 2004-06-0 ]
  • [ 204512-89-0 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In methanol; at 80℃; for 40h; [0154] 3. A mixture of 6-chloropurine riboside (0.5 gm, 1.74 mmol), <strong>[88675-24-5]3-aminotetrahydrofuran</strong> (0.325 gm, 2.6 mmol) and triethylamine (0.73 ml, 5.22 mmol) in methanol (10 ml) was heated to 80° C. for 40 hours. The mixture was cooled and concentrated under reduced pressure. The residue was chromatographed on a short column of silica gel, eluting with methylene chloride/methanol/propylamine (90/10/1). The fractions containing the product were combined and concentrated under reduced pressure. The residue was chromatographed on a chromatotron (2 mm plate, 92.5/7.5/1, methylene chloride/methanol/propylamine). The resulting white solid was recrystallized from methanol/ethyl acetate to give 0.27 gm of (4S,2R,3R,5R)-2-hydroxymethyl-5-[6-(tetrahydrofuran-3-ylamino)-purin-9-yl]-tetrahydrofuran-3,4-diol as white crystals (mp 128° C.-130° C.).
 

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