Home Cart Sign in  
Chemical Structure| 202931-77-9 Chemical Structure| 202931-77-9

Structure of 202931-77-9

Chemical Structure| 202931-77-9

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 202931-77-9 ]

CAS No. :202931-77-9
Formula : C10H13NO2
M.W : 179.22
SMILES Code : OCC1=NC=CC=C1OCC2CC2
MDL No. :MFCD27947043

Safety of [ 202931-77-9 ]

Application In Synthesis of [ 202931-77-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 202931-77-9 ]

[ 202931-77-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 14173-30-9 ]
  • [ 7051-34-5 ]
  • [ 202931-77-9 ]
YieldReaction ConditionsOperation in experiment
With potassium hydroxide; In water; dimethyl sulfoxide; a 3-Cyclopropylmethyloxy-2-hydroxymethyl Pyridine Potassium hydroxide (5.2 g, 0.093 mol) was ground to a powder under nitrogen, added to DMSO (30 ml) and stirred for 20 min under nitrogen at room temperature. The mixture was cooled to 0 C. and 3-hydroxy-2-hydroxymethyl pyridine hydrochloride (5.0 g, 0.031 mol) was added. The slurry was stirred at 0 C. for 1 h before the addition of cyclopropylmethyl bromide (3.01 ml, 4.2 g, 0.031 mol). The mixture was allowed to warm to room temperature and stirred under nitrogen overnight. Water (100 ml) was added, and the resultant solution was acidified to pH 1 with hydrochloric acid (5 N). The solution was washed with dichloromethane (3*100 ml), basified to pH 14 with sodium hydroxide solution (4 N), and washed again with dichloromethane (3*100 ml). The organic layers from the second extraction were combined, washed with water (1*100 ml) and saturated sodium chloride solution (1*100 ml), dried over magnesium sulfate and concentrated in vacuo to give 3-cyclopropylmethyloxy-2-hydroxymethyl pyridine as a dark brown solid (2.40 g). 1H NMR (250 MHz, CDCl3) δ 0.35 (2H, m), 0.65 (2H, m), 1.26 (1H, m), 3.85 (2H, d, J=6.8 Hz), 4.33 (1H, br s), 4.77 (2H, s), 7.13 (2H, m), 8.13 (2H, m); MS (ES+) m/e 180 [MH]+.
 

Historical Records