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Chemical Structure| 202590-98-5 Chemical Structure| 202590-98-5
Chemical Structure| 202590-98-5

Birabresib

CAS No.: 202590-98-5

Birabresib (OTX-015) is a potent bromodomain (BRD2/3/4) inhibitor with IC50 values ranging from 92 to 112 nM.

Synonyms: MK-8628; OTX-015

4.5 *For Research Use Only !

Cat. No.: A146187 Purity: 98%

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Product Details of Birabresib

CAS No. :202590-98-5
Formula : C25H22ClN5O2S
M.W : 491.99
SMILES Code : O=C(NC1=CC=C(O)C=C1)C[C@H]2C3=NN=C(C)N3C4=C(C(C)=C(C)S4)C(C5=CC=C(Cl)C=C5)=N2
Synonyms :
MK-8628; OTX-015
MDL No. :MFCD26960949
InChI Key :GNMUEVRJHCWKTO-FQEVSTJZSA-N
Pubchem ID :9936746

Safety of Birabresib

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Birabresib

epigenetics

Isoform Comparison

Biological Activity

Target
  • BET

    BRDs, EC50:10-19 nM

In Vitro:

Cell Line
Concentration Treated Time Description Reference
OCI-AML3, IMS-M2, K562, patient cells 500 nM 48 h and 72 h Induced differentiation and apoptosis in NPM1c AML cells PMC8615962

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02296476 Glioblastoma Multiforme PHASE2 TERMINATED 2015-10-20 -
NCT02259114 NUT Midline Carcinoma|Triple N... More >>egative Breast Cancer|Non-small Cell Lung Cancer With Rearranged ALK Gene/Fusion Protein or KRAS Mutation|Castrate-resistant Prostate Cancer|CRPC|Pancreatic Ductal Adenocarcinoma Less << PHASE1 COMPLETED 2017-03-03 -
NCT02698176 NUT Midline Carcinoma (NMC)|Tr... More >>iple Negative Breast Cancer (TNBC)|Non-small Cell Lung Cancer (NSCLC)|Castration-resistant Prostate Cancer (CRPC) Less << PHASE1 TERMINATED 2017-04-26 -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.03mL

0.41mL

0.20mL

10.16mL

2.03mL

1.02mL

20.33mL

4.07mL

2.03mL

References

 

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