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Chemical Structure| 20197-96-0 Chemical Structure| 20197-96-0

Structure of 20197-96-0

Chemical Structure| 20197-96-0

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Product Details of [ 20197-96-0 ]

CAS No. :20197-96-0
Formula : C8H4Cl2N2O
M.W : 215.04
SMILES Code : O=C1NC(Cl)=NC2=C1C=CC(Cl)=C2
MDL No. :MFCD11520688

Safety of [ 20197-96-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 20197-96-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 20197-96-0 ]

[ 20197-96-0 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 6625-94-1 ]
  • [ 20197-96-0 ]
YieldReaction ConditionsOperation in experiment
92% Step C: Preparation of 2,7-dichloro-4-oxoquinazoline. A 1.0 M aqueous solution of sodium hydroxide (19 mL, 19 mmol) was added to a mixture of <strong>[6625-94-1]2,4,7-trichloroquinazoline</strong> (2.0 g, 8.5 mmol) and THF (30 mL) that had been cooled to 0 C. The reaction mixture was allowed to warm to rt and was stirred vigorously for 2 h. The mixture was concentrated to remove the THF, and the remaining aqueous phase was cooled to 0 C. and acidified by addition of 1.0 M aqueous HCl (25 mL). The resulting mixture was allowed to stand at 0 C. for 20 min, the solid was collected by filtration and dried to provide the titled compound (1.7 g, 92%). The MS and NMR data are in agreement with those that have been previously described: Journal of Medicinal Chemistry, 2007, 50, 2297-2300.
 

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