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Chemical Structure| 201870-90-8 Chemical Structure| 201870-90-8

Structure of 201870-90-8

Chemical Structure| 201870-90-8

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Product Details of [ 201870-90-8 ]

CAS No. :201870-90-8
Formula : C10H16F3NO4S
M.W : 303.30
SMILES Code : O=C(O)[C@H](CCSC(F)(F)F)NC(OC(C)(C)C)=O

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Application In Synthesis of [ 201870-90-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 201870-90-8 ]

[ 201870-90-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24424-99-5 ]
  • [ 764-52-3 ]
  • [ 201870-90-8 ]
YieldReaction ConditionsOperation in experiment
39% With sodium hydroxide; In 1,4-dioxane; at 20℃; for 27.0h;Cooling with ice; Synthesis Example 2N-Boc-<strong>[764-52-3]trifluoromethionine</strong> (sk-269); Trifluoromethionine (3.3 g, 0.016 mol) was dissolved in 1.25 N NaOH (12.7 ml), and 1,4-dioxane (9.6 ml) was further added. Boc2O (3.7 g) dissolved in 1,4-dioxane (3.9 ml) was added dropwise in an ice bath. The mixture was stirred in the ice bath for 3 hours and allowed to react for 24 hours at room temperature. After completion of the reaction, 1,4-dioxane was evaporated, and 1 M KHSO4 (16 ml) was added thereto, followed by extraction with ethyl acetate. The extract was washed with water (6 ml) and brine (1 ml) and dried with Na2SO4. The solvent was distilled off under reduced pressure, thereby the product (1.9 g, 39%) was obtained.M.W.: 303.30Rf=0.25 (hexane/ethyl acetate=60/40)1H-NMR (CDCl3, 200 MHz) delta: 1.46 (9H, s), 2.05-2.12 (1H, m), 2.31-2.34 (1H, m), 2.98 (2H, t, J=7.6 Hz), 4.30-4.42 (1H, br), 8.45 (1H, br)19F-NMR (CDCl3, 188 MHz) delta: -42.0 (s)
 

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