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Chemical Structure| 4252-78-2 Chemical Structure| 4252-78-2
Chemical Structure| 4252-78-2

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Product Details of 2,2′,4′-Trichloroacetophenone

CAS No. :4252-78-2
Formula : C8H5Cl3O
M.W : 223.48
SMILES Code : C1=CC(=CC(=C1C(CCl)=O)Cl)Cl
MDL No. :MFCD00000934
InChI Key :VYWPPRLJNVHPEU-UHFFFAOYSA-N
Pubchem ID :20250

Safety of 2,2′,4′-Trichloroacetophenone

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302+H312+H332-H314
Precautionary Statements:P501-P260-P270-P271-P264-P280-P362+P364-P303+P361+P353-P301+P330+P331-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P405
Class:8
UN#:3265
Packing Group:

Application In Synthesis of 2,2′,4′-Trichloroacetophenone

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4252-78-2 ]

[ 4252-78-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 38170-02-4 ]
  • [ 4252-78-2 ]
  • [ 843646-60-6 ]
YieldReaction ConditionsOperation in experiment
23% With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 90℃; for 48h; To a solution of 4-iodo-2-hydroxy-benzaldehyde (5. 4 g, 22 MMOL) and 2-chloro-1- (2, 4-DICHLOROPHENYL) ETHANONE (11.2 g, 50.0 MMOL) in anhydrous N, N-DIMETHYLFORMAMIDE (100 mL) was added K2CO3 (12.0 g, 86.9 MMOL). The dark brown reaction mixture was stirred at 90 C for 48 h, then poured onto water (150 mL) and extracted with ethyl acetate. The solvent was removed under reduced pressure and the residue was purified by column chromatography, eluting with 50% hexanes in dichloromethane. The desired product was obtained as an orange solid (2.06 g, 23%). 1H-NMR (CDCI3) a 7.98 (s, 1 H), 7.70 (dd, J = 8.3, 1.3 Hz, 1 H), 7.54-7. 21 (m, 5H).
  • 2
  • [ 4252-78-2 ]
  • [ 22916-47-8 ]
 

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