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Chemical Structure| 199942-74-0 Chemical Structure| 199942-74-0

Structure of 199942-74-0

Chemical Structure| 199942-74-0

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Product Details of [ 199942-74-0 ]

CAS No. :199942-74-0
Formula : C12H23NO3
M.W : 229.32
SMILES Code : CC(C)(C)OC(=O)N1CCCC[C@H]1CCO
MDL No. :MFCD02683200
InChI Key :LTVQOFUGXMVESU-JTQLQIEISA-N
Pubchem ID :1514243

Safety of [ 199942-74-0 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H320-H400
Precautionary Statements:P264-P270-P273-P301+P310+P330-P305+P351+P338-P337+P313-P391-P405-P501
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 199942-74-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 199942-74-0 ]

[ 199942-74-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 103639-57-2 ]
  • [ 199942-74-0 ]
YieldReaction ConditionsOperation in experiment
(2S)-1-tert-Butoxycarbonyl-2-(2-hydroxyethyl)-piperidine [Ikeda, M.; Kugo, Y.; Sato, T.; J. Chem. Soc. Perkin Trans./11996, 15, 1819-1824; 860 mg, 3.75 mmol], prepared from resolved <strong>[103639-57-2](2S)-2-(2-hydroxyethyl)-piperidine</strong> [Beyerman, H. C.; Recl. Trav. Chim. Pays-Bas 1971, 90, 755-765], 1-amino-6-hydroxy-isoquinoline (1e, 480 mg. 3.0 mmol) and tributylphosphine (1.5 ml, 6.0 mmol) were dissolved in tetrahydrofuran/N,N-dimethylformamide (4:1, v/v, 15 mL). Subsequently, a solution of diethyl azodicarboxylate (0.95 ml, 6.0 mmol) in tetrahydrofuran (5 mL) was added dropwise. After stirring overnight, the mixture was diluted with dichloromethane (100 mL), washed with 2 N sodium hydroxide (2*50 mL), dried (magnesium sulphate) and concentrated under reduced pressure. Purification of the residue was accomplished using silica gel chromatography (eluent: 2-10percent methanol in dichloromethane), yielding 827 mg (60percent) of a white foam. ESI-MS: 372.2 (M+H)30. Rf (silica gel; dichloromethane/methanol, 9/1, v/v): 0.41.
 

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