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Chemical Structure| 192123-40-3 Chemical Structure| 192123-40-3

Structure of 192123-40-3

Chemical Structure| 192123-40-3

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Product Details of [ 192123-40-3 ]

CAS No. :192123-40-3
Formula : C11H21NO4
M.W : 231.29
SMILES Code : O=C(OC(C)(C)C)CCCC(N(OC)C)=O
MDL No. :MFCD12755699

Safety of [ 192123-40-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 192123-40-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 192123-40-3 ]

[ 192123-40-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 63128-51-8 ]
  • [ 6638-79-5 ]
  • [ 192123-40-3 ]
YieldReaction ConditionsOperation in experiment
95% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20℃; for 2h; EXAMPLE 40; Weinreb amide S2[00250] Weinreb amide S2: Prepared by a modification of a literature method. The starting carboxylic acid Sl (4.4 g, 23.4 mmol) was dissolved in CH2Cl2 (100 mL). N,O- dimethylhydroxylamineetaCl (2.51 g, 25.7 mmol), 1-hydroxybenzotriazole hydrate (3.93 g, <n="53"/>25.7 mmol), diisopropylethylamine (9.0 mL, 51.7 mmol), and EDCetaC1 (4.93 g, 25.7 mmol) were added sequentially to the reaction mixture. The solution was allowed to stir at room temperature for 2 h and then concentrated under vacuum to remove most of the CH2CI2. The crude material was diluted with EtOAc (300 mL), and washed successively with 5% aqueous NaHSO4 (3x), 5% aqueous NaHCtheta3 (3x), and brine. The organic layer was dried over MgSO4, filtered and concentrated to afford 5.14 g (95% yield) of the product as a pale yellow oil which was used without further purification. TLC Rf = 0.44 (EtOAc/hexanes, v/v, 1:2). 1HNMR (300MHz, CDCl3) delta 3.68 (s, 3H), 3.18 (s, 3H), 2.48 (t, J= 7.4 Hz, 2H), 2.30 (t, J = 7.4 Hz, 2H), 1.92 (m, 2H), 1.45 (s, 9H), FIG. 57. 13CNMR (75 MHz, CDCl3) delta 174.0, 172.7, 80.2, 77.5, 61.3, 35.0, 32.3, 31.0, 28.2, 20.2, FIG. 58. ESI-TOF-MS: [M+H]+ calculated 232.2, found 232.4.
 

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