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Chemical Structure| 18774-49-7 Chemical Structure| 18774-49-7

Structure of 18774-49-7

Chemical Structure| 18774-49-7

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Product Details of [ 18774-49-7 ]

CAS No. :18774-49-7
Formula : C10H6N2OS
M.W : 202.23
SMILES Code : OC1=C(C2=CC=CC=C2S3)C3=NC=N1
MDL No. :MFCD00839338

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Application In Synthesis of [ 18774-49-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 18774-49-7 ]

[ 18774-49-7 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 7311-95-7 ]
  • [ 60100-09-6 ]
  • [ 18774-49-7 ]
YieldReaction ConditionsOperation in experiment
83% Reflux; General procedure: The different ethyl 2-aminothiophene-3-carboxylate (5a-g) (1 eq.) and formamide (3.2mL/mmol eq.) were refluxed for 8 h. The reaction mixture was then cooled in an ice-bath and added of cold water. The precipitate formed was collected by filtration, washed thoroughly with cold water and purified by crystallisation from EtOH/H2O unless otherwise stated.
  • 2
  • [ 7311-95-7 ]
  • [ 60100-09-6 ]
  • [ 18774-49-7 ]
YieldReaction ConditionsOperation in experiment
72% at 100℃; for 3.0h; Preparation of Benzo[4.5]thieno[2,3-d]pyrimidin-4-ol (X); ix x; The solution of 10 millimol IX in 15 milliliter milliliter formamide was stirred at 1000C for 3 hours then cooled down to room temperature. The reaction mixture was poured onto crushed ice with continuous stirring then collected by filtration. The product was washed with water and n-hexane, then dried.Yield: 72 %
  • 3
  • [ 7311-95-7 ]
  • [ 18774-49-7 ]
YieldReaction ConditionsOperation in experiment
72% Preparation of Benzo[4,5]thieno[2,3-d]pyrimidin-4-ol (X) The solution of 10 millimol IX in 15 milliliter milliliter formamide was stirred at 100 C. for 3 hours then cooled down to room temperature. The reaction mixture was poured onto crushed ice with continuous stirring then collected by filtration. The product was washed with water and n-hexane, then dried. Yield: 72%
 

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