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Chemical Structure| 186663-74-1 Chemical Structure| 186663-74-1

Structure of 186663-74-1

Chemical Structure| 186663-74-1

tert-Butyl (2-hydroxyphenyl)carbamate

CAS No.: 186663-74-1

4.5 *For Research Use Only !

Cat. No.: A107344 Purity: 97%

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Product Details of [ 186663-74-1 ]

CAS No. :186663-74-1
Formula : C11H15NO3
M.W : 209.24
SMILES Code : O=C(OC(C)(C)C)NC1=CC=CC=C1O
MDL No. :MFCD06411300
InChI Key :UQLYDIDMLDTUDL-UHFFFAOYSA-N
Pubchem ID :4935485

Safety of [ 186663-74-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H317-H319
Precautionary Statements:P280-P305+P351+P338

Computational Chemistry of [ 186663-74-1 ] Show Less

Physicochemical Properties

Num. heavy atoms 15
Num. arom. heavy atoms 6
Fraction Csp3 0.36
Num. rotatable bonds 4
Num. H-bond acceptors 3.0
Num. H-bond donors 2.0
Molar Refractivity 58.71
TPSA ?

Topological Polar Surface Area: Calculated from
Ertl P. et al. 2000 J. Med. Chem.

58.56 Ų

Lipophilicity

Log Po/w (iLOGP)?

iLOGP: in-house physics-based method implemented from
Daina A et al. 2014 J. Chem. Inf. Model.

2.29
Log Po/w (XLOGP3)?

XLOGP3: Atomistic and knowledge-based method calculated by
XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry

2.11
Log Po/w (WLOGP)?

WLOGP: Atomistic method implemented from
Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.

2.55
Log Po/w (MLOGP)?

MLOGP: Topological method implemented from
Moriguchi I. et al. 1992 Chem. Pharm. Bull.
Moriguchi I. et al. 1994 Chem. Pharm. Bull.
Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.

1.79
Log Po/w (SILICOS-IT)?

SILICOS-IT: Hybrid fragmental/topological method calculated by
FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com

1.19
Consensus Log Po/w?

Consensus Log Po/w: Average of all five predictions

1.98

Water Solubility

Log S (ESOL):?

ESOL: Topological method implemented from
Delaney JS. 2004 J. Chem. Inf. Model.

-2.5
Solubility 0.664 mg/ml ; 0.00317 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Soluble
Log S (Ali)?

Ali: Topological method implemented from
Ali J. et al. 2012 J. Chem. Inf. Model.

-2.97
Solubility 0.224 mg/ml ; 0.00107 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Soluble
Log S (SILICOS-IT)?

SILICOS-IT: Fragmental method calculated by
FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com

-2.78
Solubility 0.347 mg/ml ; 0.00166 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Soluble

Pharmacokinetics

GI absorption?

Gatrointestinal absorption: according to the white of the BOILED-Egg

High
BBB permeant?

BBB permeation: according to the yolk of the BOILED-Egg

Yes
P-gp substrate?

P-glycoprotein substrate: SVM model built on 1033 molecules (training set)
and tested on 415 molecules (test set)
10-fold CV: ACC=0.72 / AUC=0.77
External: ACC=0.88 / AUC=0.94

No
CYP1A2 inhibitor?

Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set)
and tested on 3000 molecules (test set)
10-fold CV: ACC=0.83 / AUC=0.90
External: ACC=0.84 / AUC=0.91

Yes
CYP2C19 inhibitor?

Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set)
and tested on 3000 molecules (test set)
10-fold CV: ACC=0.80 / AUC=0.86
External: ACC=0.80 / AUC=0.87

No
CYP2C9 inhibitor?

Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set)
and tested on 2075 molecules (test set)
10-fold CV: ACC=0.78 / AUC=0.85
External: ACC=0.71 / AUC=0.81

No
CYP2D6 inhibitor?

Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set)
and tested on 1068 molecules (test set)
10-fold CV: ACC=0.79 / AUC=0.85
External: ACC=0.81 / AUC=0.87

No
CYP3A4 inhibitor?

Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set)
and tested on 2579 molecules (test set)
10-fold CV: ACC=0.77 / AUC=0.85
External: ACC=0.78 / AUC=0.86

No
Log Kp (skin permeation)?

Skin permeation: QSPR model implemented from
Potts RO and Guy RH. 1992 Pharm. Res.

-6.08 cm/s

Druglikeness

Lipinski?

Lipinski (Pfizer) filter: implemented from
Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev.
MW ≤ 500
MLOGP ≤ 4.15
N or O ≤ 10
NH or OH ≤ 5

0.0
Ghose?

Ghose filter: implemented from
Ghose AK. et al. 1999 J. Comb. Chem.
160 ≤ MW ≤ 480
-0.4 ≤ WLOGP ≤ 5.6
40 ≤ MR ≤ 130
20 ≤ atoms ≤ 70

None
Veber?

Veber (GSK) filter: implemented from
Veber DF. et al. 2002 J. Med. Chem.
Rotatable bonds ≤ 10
TPSA ≤ 140

0.0
Egan?

Egan (Pharmacia) filter: implemented from
Egan WJ. et al. 2000 J. Med. Chem.
WLOGP ≤ 5.88
TPSA ≤ 131.6

0.0
Muegge?

Muegge (Bayer) filter: implemented from
Muegge I. et al. 2001 J. Med. Chem.
200 ≤ MW ≤ 600
-2 ≤ XLOGP ≤ 5
TPSA ≤ 150
Num. rings ≤ 7
Num. carbon > 4
Num. heteroatoms > 1
Num. rotatable bonds ≤ 15
H-bond acc. ≤ 10
H-bond don. ≤ 5

0.0
Bioavailability Score?

Abbott Bioavailability Score: Probability of F > 10% in rat
implemented from
Martin YC. 2005 J. Med. Chem.

0.55

Medicinal Chemistry

PAINS?

Pan Assay Interference Structures: implemented from
Baell JB. & Holloway GA. 2010 J. Med. Chem.

0.0 alert
Brenk?

Structural Alert: implemented from
Brenk R. et al. 2008 ChemMedChem

1.0 alert: heavy_metal
Leadlikeness?

Leadlikeness: implemented from
Teague SJ. 1999 Angew. Chem. Int. Ed.
250 ≤ MW ≤ 350
XLOGP ≤ 3.5
Num. rotatable bonds ≤ 7

No; 1 violation:MW<1.0
Synthetic accessibility?

Synthetic accessibility score: from 1 (very easy) to 10 (very difficult)
based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties,
trained on 12'782'590 molecules and tested on 40 external molecules (r2 = 0.94)

2.11

Application In Synthesis of [ 186663-74-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 186663-74-1 ]

[ 186663-74-1 ] Synthesis Path-Downstream   1~36

  • 1
  • [ 106-93-4 ]
  • [ 186663-74-1 ]
  • [ 212180-23-9 ]
  • 2
  • [ 24424-99-5 ]
  • [ 95-55-6 ]
  • [ 186663-74-1 ]
YieldReaction ConditionsOperation in experiment
99% With iron(III) trifluoromethanesulfonate; In neat (no solvent); at 20℃; for 0.0833333h;Green chemistry; General procedure: Fe(OTf)3 (1 mol%) was added to a magnetically stirred mixture of anamine (1 mmol) and Boc2O (1 mmol) at room temperature. The mixturewas stirred until completion of the reaction (TLC), then diluted withEtOAc and washed with water. The organic layer was dried overanhydrous MgSO4, then the solvent was distillated off under vacuum toyield the highly pure N-Boc derivatives
99% at 20℃; for 0.216667h;Ionic liquid; To the ionic liquid [TPA][Pro] (1 mL) was added amine (1-14; Table-1) (1 mmol) and di-tert-butyl dicarbonate (1.2 mmol). The reaction was stirred at room temperature for an appropriate time (Table-1). After completion of the reaction as monitored by TLC, water was added to the reaction mixture and the product was extracted into ethyl acetate (3 × 20 mL). The combined organic layer was washed with brine solution and concentrated under reduced pressure to give crude product, which was purified over silica gel column to afford corresponding N-tert-butylcarbamate. The ionic liquid [TPA][Pro] in aqueous solution was recovered by removing water under reduced pressure and dried. The recovered ionic liquid was reused for five times without loss of its activity. Finally, all the compounds confirmed by their m.p.?s, IR, 1H NMR, 13C NMR, mass spectral data and elemental analysis wherever needed.
97% In tetrahydrofuran; for 16h; 2-Amino phenol (6 g, 55 mmol) was dissolved in 60 mL of THF. (Boc)20 (12 g, 55 mmol) was added to the above mixture and stirred for 16 h. The mixture was concentrated under vacuum to get a gummy mass. Gummy mass was precipitated using 20% MTBE/Hexane. Precipitated solid was filtered and washed with hexane to afford tert-butyl (2- hydroxyphenyl)carbamate (1 1.2 g, 97% yield)
96% With guanidine hydrochloride; In ethanol; at 35 - 40℃; for 0.25h; General procedure: Amine (1 mmol) was added to a magnetically stirred solution of guanidine hydrochloride (15 mol%) and di-tert-butyl dicarbonate (1.2 mmol) in EtOH (1 mL), at 35-40C and stirred for appropriate time (Table 1). After completion of the reaction (followed by TLC or GC), EtOH was evaporated under vacuum and the residue either was washed with water to remove the catalyst or was dissolved in CH2Cl2 (or EtOAc) and filtered off to separate out the catalyst. Evaporation of the organic solvent (if used in work up) gives almost a pure product. In the cases of using an excess (Boc)2O the product was washed with petroleum ether or hexane to recover the residual (Boc)2O. If necessary, the product was further purified either by crystallization (hexane and dichloromethane, or diethyl ether and petroleum ether) or silica gel column chromatography using EtOAc-hexane (1: 6) as eluent.
95% With iron oxide; In ethanol; at 20℃; for 0.5h;Green chemistry; General procedure: A round-bottom flask (10 mL), which contains EtOH(5 mL), was charged with a solution of diboc (1-2 mmol),nano-Fe3O4 (3 mol%, 0.007 g) and the amine (1 mmol). The mixture was stirred at room temperature for the appropriate time (Table 3). After completion of the reaction, the catalyst was collected by a magnet and separated from the solution of product and the remaining starting materials.After drying and evaporation of the solvent, the resulting solid was recrystallized from n-hexane or ethyl acetate(5 mL) to give the pure product. The recovered catalyst was washed with EtOH, dried and reused for the next run. The catalyst was recovered and reused for six times without any significant changes in the yield and the reaction time.
95% For the N-boc protection of amines, to solution of diboc (1 mmol) in ethanol (5 ml) was added {K*18-crown-6]Br3}n (0.001 mmol). The solution was stirred at room temperature for 1 min. The amine (1 mmol) was then added and solution as stirred at room temperature for an appropriate time (table 1). After completion of the reaction, the solvent was removed by water bath distillation. To the residue was added ethyl acetate (5 ml) and the mixture was filtered (the catalyst is insoluble in n-hexane and ethyl acetate). The solid was washed with ethyl acetate ()10 ml*2) amd combined filtrates were reduced to dryness to yield the pure products.
94% at 30℃; for 16h;Inert atmosphere; General procedure: The corresponding aminophenol (1 mmol) and Boc2O (1 mmol) were stirred at 30 C for 16 h undersolvent free conditions. The crude reaction mixture was purified by FC eluting with hexane/EtOAc(8:2).
93% at 20℃; for 0.5h;Green chemistry; General procedure: To (Boc)2O (1.0 mmol), was added an amine (1.0 mmol)and the mixture was stirred at room temperature for the time indicated in Table 1. The progress of the reaction was monitored by TLC. In most cases, the BOC protected product was found to be sufficiently pure and did not require any further purification. In some cases the product was purified by silica gel column chromatography (1:2; EtOAc/ Petrolium ether).All products were characterized by IR, 1H NMR and their physical properties.
92% With 1,3-disulfonic acid imidazolium hydrogen sulfate; In neat (no solvent); at 20℃; for 0.133333h;Green chemistry; General procedure: Amine (1 mmol) was added to the mixture of (Boc)2O (1 mmol) and DSIMHS (6.5 mg, ~ 0.02 mmol) with constant stirring at room temperature under solvent-free conditions. After completion of the reaction (monitored by TLC), ethyl acetate (3 × 5 mL) was added to the reaction mixture and the catalyst was decanted and washed with ethyl acetate (2 × 5 mL) and dried. The product was purified by column chromatography, using ethyl acetate-petroleum ether (2:8) eluent.
87.7% In tetrahydrofuran;Inert atmosphere; To a stirred solution of 2-aminophenol (5.0 g, 45.87 mmol) in anhydrous THF(50 mL) was added di-t-butyl dicarbonate (10.5 g, 48.17 mmol) dropwise, and thesolution was stirred overnight under argon atmosphere. Then the reaction mixture wasdiluted with ethyl acetate (80 mL) and washed with saturated brine (60 mL), water(60 mL×2), and then dried over anhydrous magnesium sulfate. The crude product waspurified by silica gel column chromatography (petroleum ether/ethyl acetate = 20:1)to afford the title compound as a white solid (8.4 g, 87.7%); mp 148-150 C; 1H NMR(400 MHz, Acetone-d6) delta (ppm) 8.86 (s, 1H), 7.73 (d, J = 7.6 Hz, 1H), 7.63 (brs, 1H),6.89-6.82 (m, 3H), 1.51 (s, 9H); HRMS (ESI): m/z, Calcd. for C6H8ON [M+H-Boc]+:110.0600, Found 110.0602.
80% In tetrahydrofuran; at 20℃; for 15h;Inert atmosphere; Di-tert-butyldicarbonate (11 mmol) was added to a stirred solution of 2-aminophenol (10 mmol) in dry THF (15 mL). The reaction mixture was stirred for 15 hours at room temperature (RT) under a nitrogen atmosphere. Then, the solvent was evaporated under vacuum and the resulting reaction mixture was washed with pentane (20 mL) and dissolved into diethyl ether (30 mL). Diethyl ether portion was washed with diluted HCl (10 mL), then dried over Na2SO4 and filtered. On evaporation under vacuum the targeted compound was obtained as a white solid (80%). 1H NMR data were: deltaH (500 MHz; CDCl3) 8.17 (1H, s, H-N), 7.11-6.81 (4H, m, ArH), and 1.52 (9H, s, CH3); and deltac (500 MHz; CDCl3) 155.0 (C=O), 147.2 (C), 125.8 (C), 121.6 (CH), 120.7 (CH), 118.6 (CH), 82.0 (C), and 28.35 (CH3).
42.4% With triethylamine; In tetrahydrofuran; water; To the solution of 2-aminophenol (1) (4?g, 36.6?mmol) in 60?mL THF-water (1:1 v/v) triethylamine (Et3N) (9.8?mL, 44.1?mmol) was added. Then, BOC anhydride (8.4?mL, 36.6?mmol) was added and stirred overnight. The reaction mixture was diluted with water and subsequently extracted with ethyl acetate. The organic layer was dried over Na2SO4, and the solvent was evaporated. The crude mixture was purified via column chromatography (hexane:EtOAc, 3:1) to get desired product in a light orange color. Yield?=?3?g, (42.4%). 1H-NMR (DMSO-d6, 300?MHz, delta in ppm): 9.74 (1H, s, Ar-OH), 7.79 (1H, d, -NHCCH), 7.60-7.57 (1H, d, -OHCCH), 6.87-6.74 (1H, m, -CHCHCH-), 1.46 (9H, s, -CH3).
In dichloromethane; (a) To a solution of 2-aminophenol (2.84 g) in dichloromethane (120 ml) was added di-tert-butyl dicarbonate (6.55 g). The mixture was stirred at room temperature for 18 hours. The mixture was partitioned between water and dichloromethane. The organic extracts were dried (MgSO4) and evaporated to give a solid which was purified by column chromatography on silica eluding with a mixture of ethyl acetate and hexane (20:80) to give 2-tert-butyloxycarbonylaminophenol (1.80 g); NMR Spectrum 9.7 (s, 1H), 7.7 (s, 1H), 7.6 (d, 1H), 6.7-6.9 (m, 3H), 1.45 (s, 9H); Mass Spectrum m/z=210 (M+H).
8.1 g With triethylamine; In pyridine; at 0 - 25℃; for 12h; 2-aminophenol (3.93 g, 36 mmol) was stirred with te/t-butoxycarbonyl dicarbonate (8.32 g, 38 mmol) in dry pyridine (30 mL) with triethylamine (4 mL) warming from 0C to 25C over 12 h. The volatiles were evaporated and the residue partitioned between diethyl ether and phosphate buffer (pH=10); the ether layer was washed with phosphate buffer then brine, dried on Na2S04, filtered and evaporated to yield 8.1 g of dark crude product which could be purified by column chromatography (20:1->5:1 Hex:EA), or by fractional crystallisations from acetone-hexane followed by hot hexane trituration. NMR spectra matched literature dataC45]: ^-NMR (400 MHz): delta = 8.15 (s br, 1H), 7.08-7.00 (m, 2H), 6.99 (d, 7.9 Hz, 1H), 6.88 (~t, 7.5 Hz, 1H), 6.69 (s, 1H), 1.56 (s, 9H) ppm. 13C-NMR (100 MHz): delta = 155.1, 147.6, 125.7, 125.5, 121.5, 120.7, 119.1, 82.2, 28.3 (x3) ppm. DIMS(+): 210 Th = [MH]+.
180 g In dichloromethane; Petroleum ether; at 25 - 40℃; for 10h; A mixture of dichioromethane (500 ml) and 2-aminophenol (100 gms) were stirred for 15 minutes at 25-30C. Di-tert-butyl dicarbonate (240 gms) was slowly added to thereaction mixture at 25-30C. Heated the reaction mixture to 35-40C and stirred for 10 hours at the same temperature. Distilled off the solvent completely from the reaction mixture under reduced pressure. Petroleum ether (200 ml) was added to the obtained compound at below 40C and stirred for 15 minutes at the same temperature. Distilled off the solvent completely from the reaction mixture under reduced pressure. Petroleum ether (500 ml) was added to theobtained compound at 25-30C. Heated the reaction mixture to 50-55C and stirred for 1 hour at the same temperature. Cooled the reaction mixture to 25-30C and stirred for 3 hours at the same temperature. Filtered the solid, washed with petroleum ether and dried to get the title compound. Yield: 180 gms; Melting point: 140-144C

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  • 3
  • [ 186663-74-1 ]
  • [ 95-55-6 ]
  • 4
  • [ 24424-99-5 ]
  • [ 88-75-5 ]
  • [ 186663-74-1 ]
  • 5
  • tert-butyl [2-(tert-butyldimethylsilyloxy)phenyl]carbamate [ No CAS ]
  • [ 186663-74-1 ]
  • 6
  • [ 3422-01-3 ]
  • [ 186663-74-1 ]
  • 7
  • [ 100-39-0 ]
  • [ 186663-74-1 ]
  • [ 186663-07-0 ]
YieldReaction ConditionsOperation in experiment
98% With potassium carbonate; In N,N-dimethyl-formamide; at 60℃;Inert atmosphere; General procedure: To a solution of the corresponding N-Boc-aminophenol (1 mmol) in DMF (2 mL), K2CO3 (207 mg,1.5 mmol) and the required benzyl bromide (1 mmol) were added. The mixture was stirred at 60 Cuntil no starting material was observed by TLC. A saturated aqueous solution of ammonium chloridewas added (5 mL) and the resulting mixture extracted with EtOAc (10 mL ×3), the organic extractswashed with brine (20 mL) and dried over MgSO4. The crude product was purified by FC eluting withhexane/EtOAc (95:5 ? 9:1).
  • 8
  • [ 106-95-6 ]
  • [ 186663-74-1 ]
  • [ 820975-68-6 ]
  • 9
  • [ 18162-48-6 ]
  • [ 186663-74-1 ]
  • tert-butyl [2-(tert-butyldimethylsilyloxy)phenyl]carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
100% With 1H-imidazole; In N,N-dimethyl-formamide; at 20℃; To the stirred solution of Phenol (1 mmol) in DMF (5 volume) was added imidazole (2 mmol) at room temperature and after 5 minutes TBDMS chloride (1.2mmol) was added and stirring continued untill completion of reaction (TLC monitoring).Next, charged water (5 volumes) to the reactio mass and extracted with diethyl ether (2X10 volumes). The combined organic layer was washed with brine(5 vol), dried (Na2SO4)and concentrated under vacuumwhich gave respective aryl TBDMS ethers in quantitative yields.
  • 10
  • [ 954153-16-3 ]
  • [ 186663-74-1 ]
  • [ 954153-17-4 ]
YieldReaction ConditionsOperation in experiment
100% With potassium carbonate; In N,N-dimethyl-formamide; at 20℃; for 3h; To <strong>[186663-74-1]tert-butyl (2-hydroxyphenyl)carbamate</strong> (428 mg, 2.04 mmol) and E76C (748 mg, 1.95 mmol) in 3.9 mL of N,N-dimethylformamide was added potassium carbonate (807 mg, 5.84 mmol). The reaction was stirred at room temperature for 3 h. The mixture was diluted with ethyl acetate, washed with water and brine, dried over magnesium sulfate and concentrated. The residue was chromatographed on silica gel eluting with hexanes/ethyl acetate to provide E76D as a white solid (1.00 g, 100%); HPLC (Method 8) tR=4.21 min.
  • 11
  • [ 33797-51-2 ]
  • [ 186663-74-1 ]
  • tert-butyl-3-((dimethylamino)methyl)-2-hydroxyphenylcarbamate [ No CAS ]
  • 12
  • [ 13154-24-0 ]
  • [ 186663-74-1 ]
  • [ 194869-12-0 ]
  • 14
  • [ 186663-74-1 ]
  • [ 820975-70-0 ]
  • 15
  • [ 186663-74-1 ]
  • tert-butyl-2,5-dihydro-6H-1,6-benzoxazocine-6-carboxylate [ No CAS ]
  • 17
  • [ 186663-74-1 ]
  • [ 28289-35-2 ]
  • 18
  • [ 186663-74-1 ]
  • [ 500138-65-8 ]
  • 19
  • [ 186663-74-1 ]
  • [ 727404-86-6 ]
  • 20
  • [ 186663-74-1 ]
  • 6-methylpiperidine-2,3-dione 3-[(2-benzyloxyphenyl)hydrazone] [ No CAS ]
  • 21
  • [ 186663-74-1 ]
  • 3-(2-tert-butoxycarbonylaminopropyl)-7-ethoxycarbonylmethoxyindole [ No CAS ]
  • 22
  • [ 186663-74-1 ]
  • potassium; 3-(2-amino-propyl)-7-benzyloxy-1<i>H</i>-indole-2-carboxylate [ No CAS ]
  • 23
  • [ 186663-74-1 ]
  • [ 443921-86-6 ]
  • 24
  • [ 186663-74-1 ]
  • 2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-6-iodo-phenylamine [ No CAS ]
  • 25
  • [ 186663-74-1 ]
  • [ 443921-87-7 ]
  • 26
  • [ 186663-74-1 ]
  • [ 443921-82-2 ]
  • 27
  • [ 186663-74-1 ]
  • (S)-2-Amino-4-[4-((S)-2-benzyloxycarbonylamino-2-tert-butoxycarbonyl-ethyl)-benzooxazol-2-yl]-butyric acid methyl ester [ No CAS ]
  • 28
  • [ 186663-74-1 ]
  • methyl (7S,10S,13S)-7-acetylamino-10-carboxymethyl-8,11-dioxo-19-oxa-9,12,17-triazatricyclo[14.2.1.06,18]nonadeca-1(18),2,4,16-tetraene-13-carboxylate [ No CAS ]
  • 29
  • [ 186663-74-1 ]
  • (7S,10S,13S)-7-Acetylamino-10-benzyl-8,11-dioxo-19-oxa-9,12,17-triaza-tricyclo[14.2.1.05,18]nonadeca-1(18),2,4,16-tetraene-13-carboxylic acid [ No CAS ]
  • 30
  • [ 186663-74-1 ]
  • [ 443922-01-8 ]
  • 31
  • [ 186663-74-1 ]
  • (7S,10S,13S)-7-acetylamino-10-benzyl-8,11-dioxo-19-oxa-9,12,17-triazatricyclo[14.2.1.06,18]nonadeca-1(18),2,4,16-tetraene-13-carboxamide [ No CAS ]
  • 32
  • [ 186663-74-1 ]
  • methyl (7S,10S,13S)-7-acetylamino-10-(4-aminobutyl)-8,11-dioxo-19-oxa-9,12,17-triazatricyclo[14.2.1.06,18]nonadeca-1(18),2,4,16-tetraene-13-carboxylate [ No CAS ]
  • 33
  • [ 186663-74-1 ]
  • [ 443921-98-0 ]
  • 34
  • [ 186663-74-1 ]
  • [ 443921-99-1 ]
  • 35
  • [ 186663-74-1 ]
  • [ 443922-04-1 ]
  • 36
  • [ 186663-74-1 ]
  • [ 443921-80-0 ]
 

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Technical Information

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