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Chemical Structure| 18457-55-1 Chemical Structure| 18457-55-1
Chemical Structure| 18457-55-1

(S)-(-)-Perillyl alcohol

CAS No.: 18457-55-1

(S)-(−)-Perillyl alcohol is a monoterpene derived from lavender that induces apoptosis by inhibiting Ras protein farnesylation and upregulating the mannose-6-phosphate receptor, exhibiting significant anticancer activity.

Synonyms: (S)-Perillic Alcohol; (-)-Perillyl Alcohol; perillic alcohol

4.5 *For Research Use Only !

Cat. No.: A370070 Purity: 95% mix TBC as stabilizer

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Product Citations

Product Citations

Kumar, Vikas ; Johnson, Bryce P. ; Dimas, Dustin A. ; Singh, Shanteri ;

Abstract: The widespread utility of isoprenoids has recently sparked interest in efficient synthesis of isoprene-diphosphate precursors. Current efforts have focused on evaluating two-step "isoprenol pathways," which phosphorylate prenyl alcs. using promiscuous kinases/phosphatases. The convergence on isopentenyl phosphate kinases (IPKs) in these schemes has prompted further speculation about the class's utility in synthesizing non-natural isoprenoids. However, the substrate promiscuity of IPKs in general has been largely unexplored. Towards this goal, authors report the biochem. characterization of five novel IPKs from Archaea and the assessment of their substrate specificity using 58 alkyl-monophosphates. This study reveals the IPK-catalyzed synthesis of 38 alkyl-diphosphate analogs and discloses broad substrate specificity of IPKs. Further, to demonstrate the biocatalytic utility of IPK-generated alkyl-diphosphates, they also highlight the synthesis of alkyl-L-tryptophan derivatives using coupled IPK-prenyltransferase reactions. These results reveal IPK-catalyzed reactions are compatible with downstream isoprenoid enzymes and further support their development as biocatalytic tools for the synthesis of non-natural isoprenoids.

Keywords: alternate mevalonate pathway ; biocatalysis ; enzyme promiscuity ; natural products ; terpenoid

Alternative Products

Product Details of (S)-(-)-Perillyl alcohol

CAS No. :18457-55-1
Formula : C10H16O
M.W : 152.23
SMILES Code : OCC1=CC[C@@H](C(C)=C)CC1
Synonyms :
(S)-Perillic Alcohol; (-)-Perillyl Alcohol; perillic alcohol
MDL No. :MFCD00062995
InChI Key :NDTYTMIUWGWIMO-SNVBAGLBSA-N
Pubchem ID :369312

Safety of (S)-(-)-Perillyl alcohol

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02704858 Glioblastoma Multiforme PHASE1|PHASE2 RECRUITING 2025-12-24 University of Southern Califor... More >>nia, Los Angeles, California, 90033, United States|Georgia Cancer Center (Augusta University), Augusta, Georgia, 30912, United States|Ochsner Health, New Orleans, Louisiana, 70121, United States|Atlantic Health (Overlook Medical Center), Summit, New Jersey, 07901, United States|Northwell Health, New York, New York, 10016, United States|Wake Forest University Health Sciences, Winston-Salem, North Carolina, 27157, United States|Cleveland Clinic, Cleveland, Ohio, 44333, United States|Baylor Scott & White Health, Dallas, Texas, 75061, United States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

6.57mL

1.31mL

0.66mL

32.85mL

6.57mL

3.28mL

65.69mL

13.14mL

6.57mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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