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Chemical Structure| 184368-74-9 Chemical Structure| 184368-74-9

Structure of 184368-74-9

Chemical Structure| 184368-74-9

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Product Details of [ 184368-74-9 ]

CAS No. :184368-74-9
Formula : C12H19NO4
M.W : 241.28
SMILES Code : O=C(N1CCC(C(OC)=O)=CC1)OC(C)(C)C
MDL No. :MFCD23704701
InChI Key :BNDRQMFIDHTNGI-UHFFFAOYSA-N
Pubchem ID :11806782

Safety of [ 184368-74-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 184368-74-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 184368-74-9 ]

[ 184368-74-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 50893-53-3 ]
  • [ 24424-99-5 ]
  • [ 80845-58-5 ]
  • [ 184368-74-9 ]
YieldReaction ConditionsOperation in experiment
With sodium chloride; triethylamine; In methanol; dichloromethane; Methyl 1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydro-4-pyridinecarboxylate 4.62 g of <strong>[80845-58-5]methyl 1-benzyl-1,2,3,6-tetrahydro-4-pyridinecarboxylate</strong> was dissolved in 30 ml of dichloromethane. Under ice-cooling, 4.29 g of 1-chloroethyl chloroformate was added thereto and the resulting mixture was heated under reflux for 2 hours. After adding 50 ml of methanol, the mixture was stirred at 70 C. for 1 hour and 20 minutes. Then triethylamine was added to the reaction mixture under ice-cooling until the pH value of the mixture exceeded 7. After further adding 4.37 g of tert-butyl dicarbonate, the resulting mixture was stirred at room temperature for 10 minutes. Then the reaction mixture was concentrated under reduced pressure, diluted with ethyl acetate, washed successively with water and a saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate. After filtration, the solvent was distilled off under reduced pressure and the obtained residue was purified by silica gel column chromatography (eluted with n-hexane/ethyl acetate) to thereby give 4.46 g of the title compound as a yellow oily substance. 1H-NMR(CDCl3) delta ppm: 1.47(s, 9H), 2.40(br.s, 2H), 3.51(t, J=5.6 Hz, 2H), 3.76(s, 3H), 4.07(d, J=2.4 Hz, 2H), 6.88(br.s, 1H)
  • 2
  • [ 80845-58-5 ]
  • [ 184368-74-9 ]
 

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