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Chemical Structure| 18325-52-5 Chemical Structure| 18325-52-5

Structure of 18325-52-5

Chemical Structure| 18325-52-5

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Product Details of [ 18325-52-5 ]

CAS No. :18325-52-5
Formula : C8H11NO2S2
M.W : 217.31
SMILES Code : O=S(C1=CC=C(S)C=C1)(N(C)C)=O

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Application In Synthesis of [ 18325-52-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 18325-52-5 ]

[ 18325-52-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 383-31-3 ]
  • [ 18325-52-5 ]
YieldReaction ConditionsOperation in experiment
31% With sodium thiomethoxide; In N,N-dimethyl-formamide; at 170℃; for 16h;Sealed tube; [00728] A mixture of 4-fluorobenzene-1 -sulfonyl chloride (2.0 g, 10.3 mmol), HNMe2 (2.0M in MeOH; 1 1 .0 mL, 22.0 mmol) and DCM (1 1 .0 mL) was stirred at rt for 5 min. DCM (30 mL) was added. The organic phase was washed with 1 M HCI (30 mL) and brine (30 mL), dried over MgSCv and filtered. The solvent was removed under reduced pressure to afford 4-fluoro-/V,/V- dimethylbenzenesulfonamide as a white solid (2.12 g, quant.). A mixture of 4-fluoro-/V,/V- dimethylbenzenesulfonamide (1 .50 g, 7.39 mmol), NaSMe (2.08 g, 29.7 mmol) and DMF (9.0 mL) was stirred at 170 C in a sealed tube for 16 h. After cooling to rt, 1 M NaOH (40 mL) was added. The aqueous phase was washed with Et20 (2 chi 40 mL), acidified to pH <2 with 2 M HCI and then extracted with Et20 (3 chi 40 mL). The combined organic phase was dried over MgSCv and filtered. The solvent was removed under reduced pressure to afford 4-mercapto-/V,/V- dimethylbenzenesulfonamide as an orange oil (503 mg, 31 %). H NMR (500 MHz, CDCI3) delta 7.67 - 7.58 (m, 2H), 7.43 - 7.35 (m, 2H), 3.67 (s, 1 H), 2.71 (s, 6H).
 

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