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Chemical Structure| 18283-41-5 Chemical Structure| 18283-41-5

Structure of 18283-41-5

Chemical Structure| 18283-41-5

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Product Details of [ 18283-41-5 ]

CAS No. :18283-41-5
Formula : C7H11NO2
M.W : 141.17
SMILES Code : CC(C)CC(C#N)C(O)=O
MDL No. :MFCD09835199

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Application In Synthesis of [ 18283-41-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 18283-41-5 ]

[ 18283-41-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 760-58-7 ]
  • [ 18283-41-5 ]
YieldReaction ConditionsOperation in experiment
100% Step 3 - 2-Cyano-4-methylpentanoic acid (by sodium borohydride reduciton) A suspension of 4-methyl-2-cyano-2-butenoic acid (10g, 71 .9mmol) in water (60ml_) was cooled to 0C with an ice bath, then NaHCO3 (7.25g, 1 .2 eq.) was added slowly to the mixture. The mixture is stirred for 15 mins to provide a clear solution, then NaBH4 (5.44g, 2 eq.) was added slowly at 0C and the reaction was stirred at room temperature for 5h. The mixture was cooled down to 0C and a solution of HCI 20% (44ml_, 4 eq.) was slowly added to the mixture (pH= 2-3). The product was extracted with EtOAc (3x 30ml_) and the combined organic phases were washed with water (3x 20 ml_), dried over MgSO , filtered and evaporated under reduced pressure to give material identical to that obtained by the hydrogenation route (10.2g, 100%).
  • 2
  • [ 760-58-7 ]
  • [ 18283-41-5 ]
  • [ 100869-07-6 ]
 

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