Home Cart Sign in  
Chemical Structure| 182570-28-1 Chemical Structure| 182570-28-1

Structure of 182570-28-1

Chemical Structure| 182570-28-1

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 182570-28-1 ]

CAS No. :182570-28-1
Formula : C11H12O4
M.W : 208.21
SMILES Code : O=C([C@@H]1COC2=C(C=C(OC)C=C2)C1)O
MDL No. :MFCD10696117
InChI Key :YFYLMFXPYODSEB-QMMMGPOBSA-N
Pubchem ID :7061285

Safety of [ 182570-28-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 182570-28-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 182570-28-1 ]

[ 182570-28-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 182570-26-9 ]
  • [ 182570-28-1 ]
  • (R)-6-methoxychroman-3-carboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
1.65 g; 39.3% With (1R,2R)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol; In methanol; acetonitrile; Raw material and solvent loading: racemic <strong>[182570-26-9]6-methoxychroman-3-carboxylic acid</strong> (1 eq, 2.80 g), dissolving agent (1R, 2R)-2-amino-1-(4 -Nitrophenyl)propane-1,3-diol (1.5 eq, 4.28g), acetonitrile (300mL), MeOH (30mL); eluted solid eluted with acetonitrile (500mL) to give (R)-6- Oxychroman-3-carboxylic acid-(1R,2R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol salt 2.79 g. The organic solvent used for the extraction was ethyl acetate (100 mL) and water (100 mL). The solvent used for recrystallization was n-hexane (100 mL) and acetonitrile (10 mL). Finally, 1.10 g of (R)-<strong>[182570-26-9]6-methoxychroman-3-carboxylic acid</strong> was obtained in a yield of 39.3%, and the optical purity was 96.3%.The organic solvent used for the extraction of the recovery process was dichloromethane (300 mL).The recovered (1R, 2R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol 3.58 g was recovered, and the recovery was 83.6%, and the optical purity was also 25.3%. (S)-<strong>[182570-26-9]6-methoxychroman-3-carboxylic acid</strong> 1.65 g.
  • 2
  • [ 182570-26-9 ]
  • [ 182570-28-1 ]
YieldReaction ConditionsOperation in experiment
36% With (1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol; In acetonitrile; for 0.5h;Resolution of racemate; Reflux; Racemic <strong>[182570-26-9]6-methoxychroman-3-carboxylic acid</strong> (3a, 15mmol) wasdissolved in acetonitrile (300mL) and the solution was warmed to re-flux .(1S ,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-dio l(15mmol)was added in one portion and the mixture was stirred at gentle refluxfor 30min. Methanol was then added dropwise until the solution be-came completely clear. The mixture was then allowed to crystallize atambient temperature overnight. The precipitate was collected by fil-tration, washed with MeCN, and dried to affor d asalt .The nthi ssaltwas treated with ethyl acetate (100mL) and water (100mL), acidifiedwith 6M aqueous HCl (10mL), and stirred for 10min. The organiclayer was separated and washed with water (100mL), dried overNa 2 SO 4 , and concentrated to dryness to obtain (S)-3a. Finally, the ob-tained (S)-3a was then recrystallized with hexane/ethyl acetate toproduce(S)-3ain36%yieldand97.1%ee(mobilephase:isopropanol/hexane/TFA=50mL: 50mL: 0.5mL).
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 182570-28-1 ]

Ethers

Chemical Structure| 182570-27-0

A543438 [182570-27-0]

(R)-6-Methoxychroman-3-carboxylic acid

Similarity: 1.00

Chemical Structure| 182570-26-9

A869398 [182570-26-9]

6-Methoxychroman-3-carboxylic acid

Similarity: 1.00

Carboxylic Acids

Chemical Structure| 182570-27-0

A543438 [182570-27-0]

(R)-6-Methoxychroman-3-carboxylic acid

Similarity: 1.00

Chemical Structure| 1512523-25-9

A586303 [1512523-25-9]

7-Methylchroman-3-carboxylic acid

Similarity: 1.00

Chemical Structure| 182570-26-9

A869398 [182570-26-9]

6-Methoxychroman-3-carboxylic acid

Similarity: 1.00

Chemical Structure| 944899-30-3

A693297 [944899-30-3]

6-Methylchroman-3-carboxylic acid

Similarity: 0.98

Chemical Structure| 1260606-65-2

A827550 [1260606-65-2]

(S)-6-Methylchroman-3-carboxylic acid

Similarity: 0.98

Related Parent Nucleus of
[ 182570-28-1 ]

Other Aromatic Heterocycles

Chemical Structure| 182570-27-0

A543438 [182570-27-0]

(R)-6-Methoxychroman-3-carboxylic acid

Similarity: 1.00

Chemical Structure| 1512523-25-9

A586303 [1512523-25-9]

7-Methylchroman-3-carboxylic acid

Similarity: 1.00

Chemical Structure| 182570-26-9

A869398 [182570-26-9]

6-Methoxychroman-3-carboxylic acid

Similarity: 1.00

Chemical Structure| 944899-30-3

A693297 [944899-30-3]

6-Methylchroman-3-carboxylic acid

Similarity: 0.98

Chemical Structure| 1260606-65-2

A827550 [1260606-65-2]

(S)-6-Methylchroman-3-carboxylic acid

Similarity: 0.98