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Heterocyclic Building Blocks
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[ CAS No. 1824270-14-5 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
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3d Animation Molecule Structure of 1824270-14-5
Chemical Structure| 1824270-14-5
Chemical Structure| 1824270-14-5
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Quality Control of [ 1824270-14-5 ]

COA NMR CNMR HPLC LC-MS

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Product Citations

Product Details of [ 1824270-14-5 ]

CAS No. :1824270-14-5 MDL No. :MFCD28129772
Formula : C9H5BrClN Boiling Point : -
Linear Structure Formula :- InChI Key :BTLUGEXANPINDI-UHFFFAOYSA-N
M.W : 242.50 Pubchem ID :130139005
Synonyms :

Safety of [ 1824270-14-5 ]

Signal Word:Danger Class:8,6.1
Precautionary Statements:P261-P280-P301+P310-P305+P351+P338 UN#:2923
Hazard Statements:H301-H315-H318-H335-H413 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 1824270-14-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1824270-14-5 ]

[ 1824270-14-5 ] Synthesis Path-Downstream   1~9

  • 1
  • [ 1125-60-6 ]
  • [ 1824270-14-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: pyridine / 20 °C 2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 72 h / Heating 3.1: dibromoisocyanuric acid / N,N-dimethyl-formamide / 3 h / 65 °C 4.1: hydrogenchloride / ethanol; water / 3 h / Reflux 5.1: sodium nitrite; acetic anhydride; sodium hydrogensulfite / ethanol; water / 0.17 h / 20 °C 5.2: 20 °C
Reference： [1]Kaniskan, H. Ümit; Eram, Mohammad S.; Zhao, Kehao; Szewczyk, Magdalena M.; Yang, Xiaobao; Schmidt, Keith; Luo, Xiao; Xiao, Sean; Dai, Miao; He, Feng; Zang, Irene; Lin, Ying; Li, Fengling; Dobrovetsky, Elena; Smil, David; Min, Sun-Joon; Lin-Jones, Jennifer; Schapira, Matthieu; Atadja, Peter; Li, En; Barsyte-Lovejoy, Dalia; Arrowsmith, Cheryl H.; Brown, Peter J.; Liu, Feng; Yu, Zhengtian; Vedadi, Masoud; Jin, Jian [Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 1204 - 1217]
  • 2
  • [ 27461-33-2 ]
  • [ 1824270-14-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 72 h / Heating 2.1: dibromoisocyanuric acid / N,N-dimethyl-formamide / 3 h / 65 °C 3.1: hydrogenchloride / ethanol; water / 3 h / Reflux 4.1: sodium nitrite; acetic anhydride; sodium hydrogensulfite / ethanol; water / 0.17 h / 20 °C 4.2: 20 °C
Reference： [1]Kaniskan, H. Ümit; Eram, Mohammad S.; Zhao, Kehao; Szewczyk, Magdalena M.; Yang, Xiaobao; Schmidt, Keith; Luo, Xiao; Xiao, Sean; Dai, Miao; He, Feng; Zang, Irene; Lin, Ying; Li, Fengling; Dobrovetsky, Elena; Smil, David; Min, Sun-Joon; Lin-Jones, Jennifer; Schapira, Matthieu; Atadja, Peter; Li, En; Barsyte-Lovejoy, Dalia; Arrowsmith, Cheryl H.; Brown, Peter J.; Liu, Feng; Yu, Zhengtian; Vedadi, Masoud; Jin, Jian [Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 1204 - 1217]
  • 3
  • [ 2204256-64-2 ]
  • [ 1824270-14-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: dibromoisocyanuric acid / N,N-dimethyl-formamide / 3 h / 65 °C 2.1: hydrogenchloride / ethanol; water / 3 h / Reflux 3.1: sodium nitrite; acetic anhydride; sodium hydrogensulfite / ethanol; water / 0.17 h / 20 °C 3.2: 20 °C
Reference： [1]Kaniskan, H. Ümit; Eram, Mohammad S.; Zhao, Kehao; Szewczyk, Magdalena M.; Yang, Xiaobao; Schmidt, Keith; Luo, Xiao; Xiao, Sean; Dai, Miao; He, Feng; Zang, Irene; Lin, Ying; Li, Fengling; Dobrovetsky, Elena; Smil, David; Min, Sun-Joon; Lin-Jones, Jennifer; Schapira, Matthieu; Atadja, Peter; Li, En; Barsyte-Lovejoy, Dalia; Arrowsmith, Cheryl H.; Brown, Peter J.; Liu, Feng; Yu, Zhengtian; Vedadi, Masoud; Jin, Jian [Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 1204 - 1217]
  • 4
  • [ 2204248-22-4 ]
  • [ 1824270-14-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: hydrogenchloride / ethanol; water / 3 h / Reflux 2.1: sodium nitrite; acetic anhydride; sodium hydrogensulfite / ethanol; water / 0.17 h / 20 °C 2.2: 20 °C
Reference： [1]Kaniskan, H. Ümit; Eram, Mohammad S.; Zhao, Kehao; Szewczyk, Magdalena M.; Yang, Xiaobao; Schmidt, Keith; Luo, Xiao; Xiao, Sean; Dai, Miao; He, Feng; Zang, Irene; Lin, Ying; Li, Fengling; Dobrovetsky, Elena; Smil, David; Min, Sun-Joon; Lin-Jones, Jennifer; Schapira, Matthieu; Atadja, Peter; Li, En; Barsyte-Lovejoy, Dalia; Arrowsmith, Cheryl H.; Brown, Peter J.; Liu, Feng; Yu, Zhengtian; Vedadi, Masoud; Jin, Jian [Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 1204 - 1217]
  • 5
  • [ 2204251-03-4 ]
  • [ 1824270-14-5 ]
YieldReaction ConditionsOperation in experiment
100 mg Stage #1: C9H6BrClN2 With acetic anhydride; sodium hydrogensulfite; sodium nitrite In ethanol; water at 20℃; for 0.166667h; Stage #2: With acetic acid In ethanol; water at 20℃;
Reference： [1]Kaniskan, H. Ümit; Eram, Mohammad S.; Zhao, Kehao; Szewczyk, Magdalena M.; Yang, Xiaobao; Schmidt, Keith; Luo, Xiao; Xiao, Sean; Dai, Miao; He, Feng; Zang, Irene; Lin, Ying; Li, Fengling; Dobrovetsky, Elena; Smil, David; Min, Sun-Joon; Lin-Jones, Jennifer; Schapira, Matthieu; Atadja, Peter; Li, En; Barsyte-Lovejoy, Dalia; Arrowsmith, Cheryl H.; Brown, Peter J.; Liu, Feng; Yu, Zhengtian; Vedadi, Masoud; Jin, Jian [Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 1204 - 1217]
  • 6
  • [ 1824270-14-5 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: copper(l) iodide; potassium carbonate; <i>L</i>-proline; ammonium hydroxide / dimethyl sulfoxide / 70 °C / Inert atmosphere 2: N,N-dimethyl-formamide; dichloromethane / 20 °C
Reference： [1]Kaniskan, H. Ümit; Eram, Mohammad S.; Zhao, Kehao; Szewczyk, Magdalena M.; Yang, Xiaobao; Schmidt, Keith; Luo, Xiao; Xiao, Sean; Dai, Miao; He, Feng; Zang, Irene; Lin, Ying; Li, Fengling; Dobrovetsky, Elena; Smil, David; Min, Sun-Joon; Lin-Jones, Jennifer; Schapira, Matthieu; Atadja, Peter; Li, En; Barsyte-Lovejoy, Dalia; Arrowsmith, Cheryl H.; Brown, Peter J.; Liu, Feng; Yu, Zhengtian; Vedadi, Masoud; Jin, Jian [Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 1204 - 1217]
  • 7
  • [ 1824270-14-5 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: copper(l) iodide; potassium carbonate; <i>L</i>-proline; ammonium hydroxide / dimethyl sulfoxide / 70 °C / Inert atmosphere 2: N,N-dimethyl-formamide; dichloromethane / 20 °C 3: sodium hydroxide / methanol; water
Reference： [1]Kaniskan, H. Ümit; Eram, Mohammad S.; Zhao, Kehao; Szewczyk, Magdalena M.; Yang, Xiaobao; Schmidt, Keith; Luo, Xiao; Xiao, Sean; Dai, Miao; He, Feng; Zang, Irene; Lin, Ying; Li, Fengling; Dobrovetsky, Elena; Smil, David; Min, Sun-Joon; Lin-Jones, Jennifer; Schapira, Matthieu; Atadja, Peter; Li, En; Barsyte-Lovejoy, Dalia; Arrowsmith, Cheryl H.; Brown, Peter J.; Liu, Feng; Yu, Zhengtian; Vedadi, Masoud; Jin, Jian [Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 1204 - 1217]
  • 8
  • [ 1824270-14-5 ]
  • [ 2206762-36-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: copper(l) iodide; potassium carbonate; <i>L</i>-proline; ammonium hydroxide / dimethyl sulfoxide / 70 °C / Inert atmosphere 2: N,N-dimethyl-formamide; dichloromethane / 20 °C 3: sodium hydroxide / methanol; water 4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 20 °C
Reference： [1]Kaniskan, H. Ümit; Eram, Mohammad S.; Zhao, Kehao; Szewczyk, Magdalena M.; Yang, Xiaobao; Schmidt, Keith; Luo, Xiao; Xiao, Sean; Dai, Miao; He, Feng; Zang, Irene; Lin, Ying; Li, Fengling; Dobrovetsky, Elena; Smil, David; Min, Sun-Joon; Lin-Jones, Jennifer; Schapira, Matthieu; Atadja, Peter; Li, En; Barsyte-Lovejoy, Dalia; Arrowsmith, Cheryl H.; Brown, Peter J.; Liu, Feng; Yu, Zhengtian; Vedadi, Masoud; Jin, Jian [Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 1204 - 1217]
  • 9
  • [ 1824270-14-5 ]
  • [ 2204250-99-5 ]
YieldReaction ConditionsOperation in experiment
With ammonium hydroxide; copper(l) iodide; potassium carbonate; <i>L</i>-proline In dimethyl sulfoxide at 70℃; Inert atmosphere;
Reference： [1]Kaniskan, H. Ümit; Eram, Mohammad S.; Zhao, Kehao; Szewczyk, Magdalena M.; Yang, Xiaobao; Schmidt, Keith; Luo, Xiao; Xiao, Sean; Dai, Miao; He, Feng; Zang, Irene; Lin, Ying; Li, Fengling; Dobrovetsky, Elena; Smil, David; Min, Sun-Joon; Lin-Jones, Jennifer; Schapira, Matthieu; Atadja, Peter; Li, En; Barsyte-Lovejoy, Dalia; Arrowsmith, Cheryl H.; Brown, Peter J.; Liu, Feng; Yu, Zhengtian; Vedadi, Masoud; Jin, Jian [Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 1204 - 1217]

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Technical Information

• Acid-Catalyzed α -Halogenation of Ketones • Addition of a Hydrogen Halide to an Internal Alkyne • Alcohols from Haloalkanes by Acetate Substitution-Hydrolysis • Alcohols React with PX3 • Alkyl Halide Occurrence • Alkylation of an Alkynyl Anion • An Alkane are Prepared from an Haloalkane • Chloroalkane Synthesis with SOCI2 • Convert Haloalkanes into Alcohols by SN2 • Friedel-Crafts Alkylation of Benzene with Haloalkanes • General Reactivity • Grignard Reaction • Halogenation of Alkenes • Hiyama Cross-Coupling Reaction • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Methylation of Ammonia • Methylation of Ammonia • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Dihalides • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Williamson Ether Syntheses
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