17823-65-3|2-((Methylthio)(phenylamino)methylene)malononitrile| Ambeed

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CAS No. :	17823-65-3
Formula :	C₁₁H₉N₃S
M.W :	215.27
SMILES Code :	N#CC(C#N)=C(SC)NC1=CC=CC=C1

Yield	Reaction Conditions	Operation in experiment
	In ethanol; for 1.5h;	2-(Bis-methylsulfanyl-methylene)-malononitrile (3.40 g, 20 mmol) and aniline (1.82 ml, 20 mmol) were refluxed in ethanol (50 ml) for 1.5 h until reaction completion (LCMS). The mixture was allowed to cool down, the precipitate formed was filtered, washed with ethanol (3 x 7 ml), and dried on air to afford 2-(methylsulfanyl-phenylamino-methylene)-malononitrile (2.97 g, 13.8 mmol) as an off-white solid.
	In ethanol; for 8h;Reflux;	General procedure: Method A (three components)Equimolar amounts (3 mmol) of bis(methylthio)methylenemalononitrile (1) and primary amine 2 namely: aniline,4-chloro-, 2-methy-, 3-methy-, 4-methy-aniline, 2-aminopropaneor b-phenylethylamine in 40 cm3 ethanol werestirred with reflux for about 8 h,
4.85 g	In methanol; at 65℃;	Add aniline (3.00 g, 32.24 mmol), 2-(bis(methylthio)methylene)malononitrile (5.48 g, 32.24 mmol) and 50 ml methanol to a 100 ml reaction flask, and react at 65C. After the reaction was monitored by TLC, most of the methanol was evaporated under reduced pressure, cooled and filtered to obtain 4.85 g of white solid.

Precautionary Statements-General
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Prevention
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P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
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Disposal
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Physical hazards
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H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
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H204	Fire or projection hazard
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H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
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H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
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H272	May intensify fire; oxidizer
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H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
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H310	Fatal in contact with skin
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H312	Harmful in contact with skin
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H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 17823-65-3

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CAS No.: 17823-65-3

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