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Chemical Structure| 178055-99-7 Chemical Structure| 178055-99-7

Structure of 178055-99-7

Chemical Structure| 178055-99-7

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Product Details of [ 178055-99-7 ]

CAS No. :178055-99-7
Formula : C16H16O3
M.W : 256.30
SMILES Code : CC(C1=CC=C(C2=CC=C(OC)C=C2OC)C=C1)=O
MDL No. :MFCD12860959

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Application In Synthesis of [ 178055-99-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 178055-99-7 ]

[ 178055-99-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 99-90-1 ]
  • [ 133730-34-4 ]
  • [ 178055-99-7 ]
YieldReaction ConditionsOperation in experiment
82% With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,2-dimethoxyethane; water; for 17h;Heating / reflux; Into a solution of 4-bromoacetophenone (7 g, 35.4 MMOL) in DME (135 mL), were added 2, 4-dimethoxyphenyl boronic acid (8.4 g, 46.2 MMOL), Pd (PPh3) 4 (2.03 g, 1.8 MMOL), and 37 mL OF 2M NA2CO3 1-under N2. The mixture was REFLUXED with stirring for 17 hours and allowed to cool to room temperature. The reaction solution was diluted with ethyl acetate. The organic layer was separated, washed twice with water, and dried over NA2SO4. Solvent removal under reduced pressure gave a sticky residue. The residue was purified using silica gel column chromatography with ethyl acetate: hexanes (1: 4) eluents to afford 1- (2 , 4'- dimethoxy-1, 1'-biphenyl-4-yl) ethanone as a white solid. Yield: 7.45 G (82%). H NMR (DMSO-d6) 8 7.95 (d, 2H), 7.58 (d, 2H), 7.28 (d, 1H), 6.65 (t, 2H), 3.81 (s, 3H), 3.77 (s, 3H), 2.58 (s, 3H)
  • 2
  • [ 99-91-2 ]
  • [ 133730-34-4 ]
  • [ 178055-99-7 ]
 

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