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Chemical Structure| 177942-40-4 Chemical Structure| 177942-40-4

Structure of 177942-40-4

Chemical Structure| 177942-40-4

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Product Details of [ 177942-40-4 ]

CAS No. :177942-40-4
Formula : C13H9FO2
M.W : 216.21
SMILES Code : O=C(C1=C(F)C(C2=CC=CC=C2)=CC=C1)O
MDL No. :MFCD14701902

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Application In Synthesis of [ 177942-40-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 177942-40-4 ]

[ 177942-40-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 161957-56-8 ]
  • [ 98-80-6 ]
  • [ 177942-40-4 ]
YieldReaction ConditionsOperation in experiment
46% With sodium carbonate;palladium diacetate; In water; at 20℃; for 120h; a) 2-Fluorobiphenyl-3-carboxylic acid 3-Bromo-2-fluorobenzoic acid (0.50 g, 2.3 mmol), phenylboronic acid (0.28 g, 2.3 mmol), sodium carbonate (0.73 g, 6.9 mmol), and palladium (II) acetate (5 mg, 0.023 mmol) in water (10 mL) were stirred at ambient temperature for 5 days. The reaction mixture was poured into 1 N HCl solution and extracted with ethyl acetate. The ethyl acetate layer was washed with 1 N HC1 (lx), water (lx) and brine (lx), and dried over MgS04. After filtration, the solvent was removed in vacuo to yield 0.53 g of product, which was recrystallized from EtOAc/hexane (1: 1) to yield 2-fluorobiphenyl-3-carboxylic acid (225 mg, 46%) as a white crystalline solid. 1H-NMR (300 MHz, d6-DMSO): 8 13.29 (1H, br s, exchangeable), 7.90- 7. 80 (1H, m), 7. 76-7.66 (1H, m), 7. 59-7. 33 (6H, m).
  • 2
  • [ 206551-41-9 ]
  • [ 89415-43-0 ]
  • [ 177942-40-4 ]
 

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