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Chemical Structure| 17641-09-7 Chemical Structure| 17641-09-7

Structure of 17641-09-7

Chemical Structure| 17641-09-7

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Product Details of [ 17641-09-7 ]

CAS No. :17641-09-7
Formula : C9H10INO2
M.W : 291.09
SMILES Code : O=C(NC1=CC=CC(OC)=C1)CI

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Application In Synthesis of [ 17641-09-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 17641-09-7 ]

[ 17641-09-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 17641-08-6 ]
  • [ 17641-09-7 ]
YieldReaction ConditionsOperation in experiment
With potassium iodide; In acetone; for 6h;Reflux; General procedure: A stirred solution of aniline derivatives 1a-h (0.05 mol) in dichloromethane DCM (50 mL) was cooled to 0 C, and chloroacetyl chloride (0.06 mol) and triethylamine (0.06 mol) was added dropwise to the solution. The resulting mixture was warmed to room temperature and stirred overnight. The organic phase was diluted with DCM (50 mL) and washed with 0.5 M HCl (50 mL), then saturated with NaHCO3 and brine. The organic layer was collected and dried over anhydrous Na2SO4. Then, the solvent was removed under reduced pressure. The 2-chloro-N-phenylancetamide derivatives (5 mmol) obtained by recrystallization were refluxed with potassium iodide (7.5 mmol) in acetone (10 mL) for 6 h, and the solvent was evaporated in vacuo. Water (50 mL) was added to the reaction mixture, and the organic phase extracted with ethyl acetate was washed with brine, and dried over anhydrous Na2SO4. The solvent was evaporated, then recrystallized from ethyl acetate to obtain Compounds 2a-h [1-3]. Moxifloxacin (2 mmol) and TEA (4.4 mmol) were added to a stirred solution of 2-iodo-N-phenylancetamide derivatives 2a-h (2.2 mmol) in acetonitrile (10 mL). The mixture was heated under reflux for 12 h, then the solvent was removed under vacuum. The resulting solid was recrystallized using acetonitrile to afford eight 4a-h [4].
 

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