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Chemical Structure| 17610-20-7 Chemical Structure| 17610-20-7

Structure of 17610-20-7

Chemical Structure| 17610-20-7

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Product Details of [ 17610-20-7 ]

CAS No. :17610-20-7
Formula : C16H22O
M.W : 230.35
SMILES Code : O=CC1=C(C)C=C2C(C)(C)CCC(C)(C)C2=C1

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Application In Synthesis of [ 17610-20-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 17610-20-7 ]

[ 17610-20-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 2591-86-8 ]
  • ammonium chloride [ No CAS ]
  • [ 119999-22-3 ]
  • [ 17610-20-7 ]
YieldReaction ConditionsOperation in experiment
3.5 g (85%) With n-butyllithium; In tetrahydrofuran; 22.2 mL (35.2 mmol) of n-butyl lithium (1.6 M in hexanes) was added. After 1 hours, a solution of 3.95 mL (35.5 mmol) of N-formylpiperidine was added to a solution of 5 g (17.8 mmol) of <strong>[119999-22-3]2-bromo-3-methyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene</strong> in 50 mL of tetrahydrofuran, cooled in a dry ice/acetone bath. After 30 minutes 30 mL of saturated aqueous ammonium chloride was added to the reaction mixture. The reaction mixture was warmed to room temperature and extracted with ethyl acetate. The organic phase was separated, washed with brine, dried over sodium sulfate and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel with gradient elution (hexane-10% ethyl acetate/hexane) to provide 3.5 g (85%) of 2-formyl-3-methyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene (m.p.: 82.4-84.1 C.).
  • 2
  • [ 119999-22-3 ]
  • [ 17610-20-7 ]
YieldReaction ConditionsOperation in experiment
(b) Preparation of 5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenecarboxaldehyde Following the basic procedure of Example 11(a), from 8.44 g (30 mmol) of <strong>[119999-22-3]2-bromo-5,6,7,8-tetrahydro-3,5,5,8,8-pentamethylnaphthalene</strong>, 6.9 g (100%) of the expected aldehyde, with a melting point of 75-76 C., were obtained.
 

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