Structure of Aliskiren
CAS No.: 173334-57-1
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Aliskiren is a renin inhibitor with IC50 of 1.5 nM.
Synonyms: SPP 100; CGP 60536; Aliskiren, Enviage, Rasilez, Riprazo, SPP100, Sprimeo
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Prediction of Chameleonic Efficiency
Laurent David ; Mark Wenlock ; Patrick Barton ; Andreas Ritzén ;
Abstract: Chameleonic properties, i.e., the capacity of a molecule to hide polarity in non-polar environments and expose it in water, help achieving sufficient permeabilily and solubility for drug molecules with high MW.We present models ofexperimental measures of polarity for a set of 24 FDA approved drugs (MW 405-1113)and one PROTAC(MW 1034). Conformational ensembles in aqueous and non-polar environments were generated using molecular dynamics, A linearregression model that predicts chromatographic apparent polarity(EPSA) with a mean unsigned error of 10 A2 was derived based on separate terms for donor, acceptor, and tolal molecular SASA. A good correlation (R'0.92) with an experimental measure of hydrogen bond donor potential, Alog Poa, was found for the mean hydrogenbond donor SASA of the confommational ensemblescaled with Abraham's A hydrogen bond acidity. Two quantitative measures of chameleonic behaviour, the chameleonic efficlency indices, are introduced. We envislon that the methods presented herein will be useful to triage designed molecules and prioritize those with the best chance of achieving acceptable permeabilily and solubility.
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Keywords: chameleonic properties ; polar surface area ; hydrogen bonding ; molecular dynamics
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CAS No. : | 173334-57-1 |
Formula : | C30H53N3O6 |
M.W : | 551.76 |
SMILES Code : | CC(C)[C@@H](CC1=CC=C(OC)C(OCCCOC)=C1)C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(NCC(C)(C)C(N)=O)=O |
Synonyms : |
SPP 100; CGP 60536; Aliskiren, Enviage, Rasilez, Riprazo, SPP100, Sprimeo
|
MDL No. : | MFCD09839018 |
InChI Key : | UXOWGYHJODZGMF-QORCZRPOSA-N |
Pubchem ID : | 5493444 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Target |
|
In Vivo:
Administration | Dosage | Frequency | Description | References |
Sprague-Dawley rats | Chronic intermittent hypoxia (CIH) model | Intragastric gavage | 20 mg/kg | Once daily for 4 weeks | To investigate the potential role of aliskiren in atrial remodeling in a chronic intermittent hypoxia (CIH) rat model. Results showed that aliskiren significantly attenuated CIH-induced atrial fibrosis and electrical remodeling, and reduced the inducibility of atrial fibrillation. | PMC7502603 |
Wistar rats | Cotton-pellet-induced granuloma and formaldehyde-induced paw edema models | Oral | 15, 30, 60 mg/kg | Once daily for 7 days | To evaluate the anti-inflammatory effects of aliskiren, results showed that aliskiren significantly reduced exudate, granuloma, and paw edema, and decreased serum levels of TNF-α, VCAM-1, and hs-CRP while restoring IL-10 levels. | PMC7381093 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT00865020 | - | Completed | - | - | |
NCT00841672 | Moderate to Severe Hypertensio... More >>n Less << | Phase 3 | Completed | - | Germany ... More >> Investigative Site Berlin, Germany Philippines Investigative Site Manilla, Philippines Romania Investigative Site Bucharest, Romania Russian Federation Investigative Site Moscow, Russian Federation Singapore Investigative Site Singapore, Singapore Spain Investigative Site Madrid, Spain Less << |
NCT00841672 | - | Completed | - | - | |
NCT00219180 | Hypertension | Phase 3 | Completed | - | United States, New Jersey ... More >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Germany Investigative Centers, Germany Less << |
NCT00219011 | Heart Failure | Phase 3 | Completed | - | United States, New Jersey ... More >> Novartis Pharmaceuticals East Hanover, New Jersey, United States Germany Investigative Centers, Germany Less << |
NCT01129557 | Proteinuric Kidney Disease ... More >> Diabetic Nephropathy Hypertensive Nephrosclerosis IgA Nephropathy Focal Segmental Glomerulosclerosis Glomerulopathy (Obesity-associated) Glomerulonephritis, Membranous Less << | Phase 4 | Terminated | - | United States, New York ... More >> Columbia University Medical Center New York, New York, United States, 10032 Less << |
NCT00417170 | High Blood Pressure ... More >> Metabolic Syndrome Insulin Resistance Endothelial Dysfunction Less << | Phase 2 | Completed | - | United States, California ... More >> Novartis Investigative Site Santa Monica, California, United States, 90404 Less << |
NCT00299832 | Hypertension | PHASE3 | COMPLETED | 2025-05-07 | Novartis Pharmaceuticals, Japa... More >>n, Japan Less << |
NCT00299806 | Hypertension | PHASE3 | COMPLETED | 2025-11-06 | Novartis Pharmaceuticals, Japa... More >>n, Japan Less << |
NCT01129557 | - | Terminated | - | - | |
NCT01048047 | Hypertension | Phase 4 | Unknown | March 2010 | Italy ... More >> University of Pavia Pavia, Italy, 27100 University of Pavia Pavia, Italy Less << |
NCT00760266 | Hypertension | Phase 4 | Completed | - | United States, New Jersey ... More >> Sites in USA East Hanover, New Jersey, United States, 07936 Less << |
NCT00865020 | Hypertension | Phase 4 | Completed | - | Brazil ... More >> Investigative Site Sorocaba, Brazil Canada Investigative Site Gatineau, Canada Ecuador Investigative Site Guayaquil, Ecuador Germany Investigative Site Erfurt, Germany Hungary Invesitagtive Site Budapest, Hungary Korea, Republic of Investigative Site Cheongju, Korea, Republic of Malaysia Investigative Site Kuala Lumpur, Malaysia Mexico Investigative Site Mexico City, Mexico Panama Investigative Site Panama City, Panama Philippines Investigative Site Manila, Philippines Singapore Investigative Site Singapore, Singapore Slovakia Investigative Site Bratislava, Slovakia Spain Investigative Site Sevilla, Spain Turkey Investigative Site Istanbul, Turkey United Kingdom Investigative Site Westbury, United Kingdom Venezuela Investigative Site Caracas, Venezuela Less << |
NCT00870493 | IgA Nephropathy | Phase 3 | Completed | - | Hong Kong ... More >> Prince of Wales Hospital Shatin, Hong Kong Less << |
NCT01125514 | Heart Failure | Phase 2 | Completed | - | Germany ... More >> Novartis Investigative Site Berlin, Germany Lithuania Novartis Investigative Site Vilnius, Lithuania Less << |
NCT00386607 | - | Completed | - | - | |
NCT00461136 | Diabetes Type 2 | PHASE1|PHASE2 | COMPLETED | 2025-11-06 | Novartis, Gentofte, 2820, Denm... More >>ark Less << |
NCT00417170 | - | Completed | - | - | |
NCT01125514 | - | Completed | - | - | |
NCT00819767 | - | Completed | - | - | |
NCT00386607 | Hypertension | Phase 3 | Completed | - | United States, California ... More >> Investigative Centers San Diego, California, United States Canada Investigative Centers Canada, Canada Germany Investigative Centers Germany, Germany Netherlands Investigative Centers Netherlands, Netherlands Less << |
NCT00424541 | Hypertension | Phase 1 | Completed | - | Japan ... More >> Novartis Investigative Site Tokyo, Japan, 160-8618 Less << |
NCT00819767 | Hypertension | Phase 2 | Completed | - | Czech Republic ... More >> Investigative Site Pardubice, Czech Republic Investigative Site Prague, Czech Republic Hungary Investigative Site Budapest, Hungary Investigative Site Nyiregyhaza, Hungary Investigative Site Pilisvörösvár, Hungary Investigative Site Szentendre, Hungary Singapore Investigative Site Singapore, Singapore United Kingdom Investigative Site Leicester, United Kingdom Less << |
NCT00760266 | - | Completed | - | - | |
NCT00705575 | Hypertension | Phase 3 | Completed | - | United States, New Jersey ... More >> Investigative Site East Hanover, New Jersey, United States, 07936 Argentina Investigative Site Buenos Aires, Argentina Ecuador Investigative Site Quito, Ecuador Germany Investigative Site Berlin, Germany Guatemala Investigative Site Guatemala City, Guatemala Italy Investigative Site Rome, Italy Switzerland Investigative Site Basel, Switzerland Turkey Investigative Site Ankara, Turkey Less << |
NCT00797862 | Hypertension | Phase 3 | Completed | - | Canada ... More >> Investigative Site Toronto, Canada Costa Rica Investigative Site San Jose, Costa Rica France Investigative Site Paris, France Germany Investigative Site Bonn, Germany Greece Investigative Site Athens, Greece Guatemala Investigative Site Guatemala city, Guatemala South Africa Investigative Site Cape Town, South Africa Switzerland Investigative Site Basel, Switzerland United Kingdom Investigative Site London, United Kingdom Venezuela Investigative Site Caracas, Venezuela Less << |
NCT00705575 | - | Completed | - | - | |
NCT00923156 | Heart Failure | Phase 2 | Completed | - | Germany ... More >> Novartis Investigator Site Bad Krozingen, Germany, 79189 Novartis Investigator Site Berlin, Germany, 12207 Novartis Investigator Site Berlin, Germany, 13353 Novartis Investigator Site Göttingen, Germany, 37057 Novartis Investigator Site Jena, Germany, 07747 Novartis Investigator Site München, Germany, 80336 Poland Novartis Investigator Site Krakow, Poland, 31-501 Novartis Investigator Site Lublin, Poland, 20-090 Novartis Investigator Site Poznan, Poland, 61-848 Novartis Investigator Site Warszawa, Poland, 02-507 Novartis Investigator Site Wroclaw, Poland, 50-981 Russian Federation Novartis Investigator Site Moscow, Russian Federation, 117292 Novartis Investigator Site Moscow, Russian Federation, 119620 Novartis Investigator Site Moscow, Russian Federation, 121309 Novartis Investigator Site Moscow, Russian Federation, 121552 Novartis Investigative Site Moscow, Russian Federation Less << |
NCT00402103 | Hypertension | Phase 3 | Completed | - | United States, New Mexico ... More >> Investigative Site Santa Fe, New Mexico, United States Belgium Investigator Site Investigative Site, Belgium Denmark Investigative Center Investigative Center, Denmark Finland Investigative Site Investigative Site, Finland Germany Investigative Center Investigative Center, Germany Iceland Investigative Site Investigative Site, Iceland India Investigative Site Investigative Site, India Switzerland Investigative Site Investigative Site, Switzerland Less << |
NCT00797862 | - | Completed | - | - | |
NCT00343551 | Essential Hypertension | PHASE3 | COMPLETED | - | Investigative Centers, Germany... More >>|Novartis Pharmaceuticals, Basel, Switzerland Less << |
NCT00867490 | Hypertension | Phase 3 | Completed | - | Germany ... More >> Investigative Site Chemnitz, Germany Less << |
NCT00923156 | - | Completed | - | - | |
NCT00732407 | Diabetes Mellitus ... More >> Atherosclerosis Less << | Not Applicable | Unknown | - | - |
NCT01150357 | - | Completed | - | - | |
NCT00402103 | - | Completed | - | - | |
NCT00778921 | - | Completed | - | - | |
NCT00778921 | Hypertension | Phase 3 | Completed | - | Argentina ... More >> Investigative Site Buenos Aires, Argentina Germany Investigative Site Berlin, Germany Norway Investigative Site Oslo, Norway Poland Investigative Site Warsaw, Poland Slovakia Investigative Site Bratislava, Slovakia Sweden Investigative Site Stockholm, Sweden Turkey Investigative Site Ankara, Turkey Less << |
NCT00777946 | - | Completed | - | - | |
NCT01150357 | Hypertension | Phase 3 | Completed | - | - |
NCT00927394 | Hypertension | Phase 4 | Completed | - | United States, Delaware ... More >> Investigative Site Newark, Delaware, United States, USA United States, Missouri Investigative Site Kansas, Missouri, United States United States, New Jersey Investigative Site Camden, New Jersey, United States United States, Pennsylvania Investigative Site Philadelphia, Pennsylvania, United States Less << |
NCT00867490 | - | Completed | - | - | |
NCT00549757 | Type 2 Diabetes Mellitus ... More >> Cardiovascular Disease Less << | Phase 3 | Terminated(Lack of benefit and... More >> safety concern) Less << | - | - |
NCT00777946 | Hypertension | Phase 3 | Completed | - | Estonia ... More >> Investigative site Estonia, Estonia France Investigative site France, France Iceland Investigative Site Iceland, Iceland India Investigative Site India, India Italy Investigative site Italy, Italy Korea, Republic of Investigative Site Republic of Korea, Korea, Republic of Lithuania Investigative Site Lithuania, Lithuania Spain Investigative Site Spain, Spain Venezuela Investigative Site Venezuela, Venezuela Less << |
NCT01080768 | - | Terminated(Publication of data... More >> from a similar study made the current study redundant.) Less << | - | - | |
NCT01893788 | Hypertensive Left Ventricular ... More >>Hypertrophy Less << | Phase 4 | Unknown | - | Japan ... More >> Department of Cardiology, Nagoya University Graduate School of Medicine Recruiting Nagoya, Aichi, Japan, 466-8550 Contact: Takanori Nagahiro, MD 81-52-744-2149 t-nagahiro@med.nagoya-u.ac.jp Contact: Toyoaki Murohara, MD, PhD 81-52-744-2149 murohara@med.nagoya-u.ac.jp Less << |
NCT00739596 | Hypertension | Phase 4 | Completed | - | United States, New Jersey ... More >> Sites in USA East Hanover, New Jersey, United States Less << |
NCT01259297 | - | Terminated(Terminated early in... More >> agreement with Health Authorities for feasibility reasons) Less << | - | - | |
NCT00927394 | - | Completed | - | - | |
NCT01305850 | Peritoneal Membrane Failure | Phase 4 | Unknown | October 2011 | Thailand ... More >> Chulalongkorn University Recruiting Bangkok, Thailand, 10330 Contact: Talerngsak Kanjanabuch, Assist. Prf. 662-2564321 ext 211 golfnephro@hotmail.com Principal Investigator: Talerngsak Kanjanabuch, Assist. Prf. Sub-Investigator: Pichaya Tantiyavarong, MD Less << |
NCT01070030 | Stage II Hypertension | Phase 4 | Completed | - | Thailand ... More >> Investigative Site Bangkok, Thailand Investigative Site Chiang Mai, Thailand Investigative Site Nakhon Ratchasima, Thailand Less << |
NCT00881439 | Heart Failure ... More >> Kidney Failure Less << | Phase 2 | Terminated(Futility) | - | Netherlands ... More >> University Medical Center Groningen Groningen, Netherlands Less << |
NCT01080768 | Hypertension ... More >>Ankle Edema Less << | Phase 2 | Terminated(Publication of data... More >> from a similar study made the current study redundant.) Less << | - | Netherlands ... More >> Novartis Investigative Site Beek en Donk, Netherlands Novartis Investigative Site Bosch, Netherlands Novartis Investigative Site Den Haag, Netherlands Novartis Investigative Site Hoogwoud, Netherlands Novartis Investigative Site Lichtenvoorde, Netherlands Novartis Investigative Site Lieshout, Netherlands Novartis Investigative Site Poortvliet, Netherlands Novartis Investigative Site Utrecht, Netherlands Novartis Investigative Site Wildervank, Netherlands Less << |
NCT01259297 | Cardiovascular Events | Phase 3 | Terminated(Terminated early in... More >> agreement with Health Authorities for feasibility reasons) Less << | - | - |
NCT00549757 | - | Terminated(Lack of benefit and... More >> safety concern) Less << | - | - | |
NCT00739596 | - | Completed | - | - | |
NCT01165983 | Diabetes Type 2 | Not Applicable | Completed | - | United States, Massachusetts ... More >> Beth Israel Deaconess Medical Center, Joslin Foot Center & Microcirculation Laboratory Boston, Massachusetts, United States, 02215 Less << |
NCT00773084 | Diastolic Heart Failure | Not Applicable | Withdrawn(Difficulty in recrui... More >>ting patients and then the PI left the institution) Less << | August 2009 | United States, Texas ... More >> Texas Tech University Health Sciences Center Lubbock, Texas, United States, 79430 Less << |
NCT00464776 | Diabetes Mellitus, Type 2 | Phase 1 Phase 2 | Completed | - | Denmark ... More >> Novartis Gentofte, Denmark, 2820 Less << |
NCT01042392 | - | Completed | - | - | |
NCT00416728 | Healthy | Phase 1 | Completed | - | United States, New Jersey ... More >> Novartis Investigative Site East Hanover, New Jersey, United States, 07936-1080 Less << |
NCT01042392 | Essential Hypertension | Phase 4 | Completed | - | - |
NCT00787605 | Hypertension ... More >>Diabetes Mellitus Less << | Phase 4 | Completed | - | United States, New Jersey ... More >> Sites in USA East Hanover, New Jersey, United States, 07936 Less << |
NCT01165983 | - | Completed | - | - | |
NCT00416468 | Healthy | Phase 1 | Completed | - | United States, New Jersey ... More >> Novartis Investigative Site East Hanover, New Jersey, United States, 07936-1080 Less << |
NCT00787605 | - | Completed | - | - | |
NCT00542269 | - | Terminated(Early termination o... More >>f the study due to slow recruitment.) Less << | - | - | |
NCT00542269 | Hypertension With Metabolic Sy... More >>ndrome Less << | Phase 4 | Terminated(Early termination o... More >>f the study due to slow recruitment.) Less << | - | United Kingdom ... More >> Addenbrookes Hospital Cambridge, United Kingdom Less << |
NCT00464880 | Diabetes Type 2 | PHASE1|PHASE2 | COMPLETED | 2025-11-07 | Novartis, Gentofte, 2820, Denm... More >>ark Less << |
NCT01067326 | - | Terminated(Novartis ended all ... More >>studies regarding Aliskiren.) Less << | - | - | |
NCT00933920 | Hypertension | Phase 1 | Completed | - | India ... More >> Novartis Investigator Site Coimbatore, India Novartis Investigative Site Hyderabaad, India Novartis Investigator Site Hyderabaad, India Novartis Investigator Site Mangalore, India Novartis Investigative Site New Delhi, India Less << |
NCT01067326 | Endothelial Dysfunction | Phase 3 | Terminated(Novartis ended all ... More >>studies regarding Aliskiren.) Less << | - | United States, Minnesota ... More >> Mayo Clinic in Rochester Rochester, Minnesota, United States, 55905 Less << |
NCT01302899 | Non-diabetic Nephropathy | Phase 2 | Terminated(In consequence of t... More >>ermination of ALTITUDE. A number of studies were continued in consultation with the Altitude Data Monitoring Committee.) Less << | - | Netherlands ... More >> Novartis Investigative Site Groningen, Netherlands Novartis Investigative Site Leeuwarden, Netherlands Less << |
NCT00797316 | Hypertension | Phase 4 | Completed | - | United States, New Jersey ... More >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Less << |
NCT01302899 | - | Terminated(In consequence of t... More >>ermination of ALTITUDE. A number of studies were continued in consultation with the Altitude Data Monitoring Committee.) Less << | - | - | |
NCT01284114 | Hypertension|Chronic Kidney Di... More >>sease Less << | PHASE4 | COMPLETED | 2025-05-12 | Niimi city Yukawa National hea... More >>lth insurance clinic, Niimi, Okayama, 719-2643, Japan|Konan Hospital, Oyama, Tochigi, 329-0214, Japan|Kurosu Hospital, Sakura, Tochigi, 329-1395, Japan|Jichi Medical University, Shimotsuke, Tochigi, 3290498, Japan Less << |
NCT01284114 | Hypertension|Chronic Kidney Di... More >>sease Less << | PHASE4 | COMPLETED | 2025-05-12 | Niimi city Yukawa National hea... More >>lth insurance clinic, Niimi, Okayama, 719-2643, Japan|Konan Hospital, Oyama, Tochigi, 329-0214, Japan|Kurosu Hospital, Sakura, Tochigi, 329-1395, Japan|Jichi Medical University, Shimotsuke, Tochigi, 3290498, Japan Less << |
NCT00797316 | - | Completed | - | - | |
NCT01150201 | Kidney Disease | Phase 4 | Completed | - | China ... More >> Queen Mary Hospital Hong Kong, China Less << |
NCT01237873 | Essential Hypertension | Phase 3 | Completed | - | Japan ... More >> Novartis Investigative Site Yokohama, Kanagawa, Japan, 231-0023 Novartis Investigative Site Koshigaya city, Saitama, Japan, 343-0826 Novartis Investigative Site Edogawa-ku, Tokyo, Japan, 133-0061 Novartis Investigative Site Katsushika-ku, Tokyo, Japan, 124-0024 Novartis Investigative Site Kiyose, Tokyo, Japan, 204-0021 Novartis Investigative Site Kunitachi, Tokyo, Japan, 186-0001 Novartis Investigative Site Minato-ku, Tokyo, Japan, 105-7390 Novartis Investigative Site Minato-ku, Tokyo, Japan, 108-0075 Novartis Investigative Site Ota-ku, Tokyo, Japan, 143-0023 Novartis Investigative Site Shibuya-ku, Tokyo, Japan, 150-0002 Novartis Investigative Site Shinagawa-ku, Tokyo, Japan, 141-0032 Novartis Investigative Site Tachikawa, Tokyo, Japan, 190-0013 Novartis Investigative Site Toshima-ku, Tokyo, Japan, 171-0021 Less << |
NCT00853957 | - | Completed | - | - | |
NCT00768040 | Diabetic Macular Edema | Phase 2 | Terminated(Inadequate enrollme... More >>nt) Less << | - | United States, Arizona ... More >> Retinal Consultants of Arizona Phoenix, Arizona, United States United States, California Retina-Vitreous Associates Los Angeles, California, United States United States, Florida National Ophthalmic Research Institute Fort Myers, Florida, United States United States, Georgia Georgia Retina Atlanta, Georgia, United States United States, Maryland Elman Retina Group Baltimore, Maryland, United States United States, Massachusetts Joslin Clinic Boston, Massachusetts, United States, MA United States, Michigan Vitreo-Retinal Associates Grand Rapids, Michigan, United States United States, North Carolina Charlotte Eye, Ear, Nose and Throat Associate Charlotte, North Carolina, United States, NC United States, Ohio Retina-Associates of Cleveland, Inc Beachwood, Ohio, United States United States, Texas Retinal Consultants of Houston Houston, Texas, United States, TX Denmark Novartis Investigative Site Arhus, Denmark Novartis Investigative Site Copenhagen, Denmark Less << |
NCT01715207 | - | Completed | - | - | |
NCT00853957 | Hypertension | Phase 4 | Completed | - | United States, Illinois ... More >> Investigative Site Chicago, Illinois, United States United States, Maryland Investigative Site Baltimore, Maryland, United States Investigative Site Oxon Hill, Maryland, United States United States, Michigan Investigative Site Detroit, Michigan, United States United States, New Jersey Investigative Site Trenton, New Jersey, United States United States, New York Investigative Site Brooklyn, New York, United States Investigative Site Springfield Gardens, New York, United States United States, Pennsylvania Investigative Site Philadelphia, Pennsylvania, United States United States, Wisconsin Investigative Site Milwaukeee, Wisconsin, United States Less << |
NCT00894387 | Acute Decompensated Heart Fail... More >>ure Congestive Heart Failure Less << | Phase 3 | Completed | - | - |
NCT00768040 | - | Terminated(Inadequate enrollme... More >>nt) Less << | - | - | |
NCT00631917 | Hypertension | Phase 4 | Completed | - | United States, Missouri ... More >> Investigative Site Kansas City, Missouri, United States Argentina Investigative Site Investigative Site, Argentina Colombia Investigative Site Investigative Site, Colombia France Investigative Site Investigative Site, France Germany Investigative Site Investigative Site, Germany India Investigative Site investigative Site, India Spain Investigative Site Investigative Site, Spain Less << |
NCT00939588 | Hypertension | Phase 2 | Completed | - | Russian Federation ... More >> Novartis Investigative Site Moscow, Russian Federation Less << |
NCT00765947 | Essential Hypertension ( Mild ... More >>to Moderate) Less << | Phase 4 | Completed | - | France ... More >> Investigative Site Paris, France Hungary Investigative Site Budapest, Hungary Romania Investigative Site Bucharest, Romania Slovakia Investigative Site Bratislava, Slovakia Less << |
NCT01060865 | Blood Pressure, High | PHASE4 | TERMINATED | 2025-12-11 | Clalit health services, Hertsl... More >>iyah, Hasharon Area, Israel Less << |
NCT01827202 | Hypertension ... More >>Chronic Kidney Disease Proteinuria Less << | Phase 4 | Completed | - | Austria ... More >> Medical University of Vienna, Department of Internal Medicine III, Division of Nephrology and Dialysis Vienna, Austria, 1090 Less << |
NCT00809926 | Stage 2 Hypertension | Phase 4 | Completed | - | United States, New Jersey ... More >> Sites in USA East Hanover, New Jersey, United States, 07936 Less << |
NCT00894387 | - | Completed | - | - | |
NCT01715207 | Marfan Syndrome | Phase 3 | Completed | - | Korea, Republic of ... More >> Samsung Medical Center Seoul, Korea, Republic of, 135-710 Less << |
NCT00765947 | - | Completed | - | - | |
NCT00772577 | Hypertension | Phase 4 | Completed | - | United States, California ... More >> Investigative Site Beverly Hills, California, United States Investigative Site Santa Ana, California, United States United States, Georgia Investigative Site Conyers, Georgia, United States United States, Kentucky Investigative Site Lexington, Kentucky, United States United States, South Carolina Investigative Site Columbia, South Carolina, United States United States, Texas Investigative Site Houston, Texas, United States Less << |
NCT00631917 | - | Completed | - | - | |
NCT00809926 | - | Completed | - | - | |
NCT00719316 | Chronic Kidney Disease|Hyperte... More >>nsion|Muscle Sympathetic Nerve Activity Less << | PHASE4 | UNKNOWN | 2025-01-10 | University Medical Center utre... More >>cht, Utrecht, 3584CX, Netherlands Less << |
NCT00772577 | - | Completed | - | - | |
NCT00922311 | IgA Nephropathy | PHASE4 | COMPLETED | 2025-12-10 | Department of Medicine, The Un... More >>iversity of Hong Kong, Hong Kong, China|Queen Mary Hospital, Hong Kong, China Less << |
NCT00834041 | - | Completed | - | - | |
NCT00853658 | Chronic Heart Failure | Phase 3 | Completed | - | - |
NCT01417104 | Atherosclerosis | Phase 2 Phase 3 | Terminated(Safety concerns wit... More >>h approved medication identified in an unrelated trial) Less << | - | United States, Ohio ... More >> Ohio State University Columbus, Ohio, United States, 43210 Less << |
NCT00667719 | Essential Hypertension | Phase 3 | Completed | - | United States, Texas ... More >> Investigative Site Houston, Texas, United States Belgium Investigative Site Belgium, Belgium Egypt Investigative Site Egypt, Egypt Germany Investigative Site Germany, Germany Poland Investigative Site Poland, Poland Slovakia Investigative Site Slovakia, Slovakia Spain Investigative Site Spain, Spain Turkey Investigative Site Turkey, Turkey Less << |
NCT00834041 | Hypertension | Phase 1 Phase 2 | Completed | - | United States, Kentucky ... More >> Investigative Site Louisville, Kentucky, United States Belgium Investigative Site Brussels, Belgium Brazil Investigative Site Brasilia, Brazil Hungary Investigative Site Budapest, Hungary Poland Investigative Site Warsaw, Poland Less << |
NCT01176032 | Hypertension ... More >>Left Ventricle Hypertrophy Less << | Phase 4 | Completed | - | Spain ... More >> Novartis Investigative Site Sanlúcar de Barrameda, Andalucia, Spain, 11540 Novartis Investigative Site Sevilla, Andalucia, Spain, 41009 Novartis Investigative Site Sevilla, Andalucia, Spain, 41013 Novartis Investigative Site Utrera, Andalucia, Spain, 41710 Novartis Investigative Site Burgos, Castilla y Leon, Spain, 09005 Novartis Investigative Site Barcelona, Cataluña, Spain, 08036 Novartis Investigative Site Girona, Cataluña, Spain, 17007 Novartis Investigative Site L'Hospitalet de Llobregat, Cataluña, Spain, 08907 Novartis Investigative Site Santa Coloma de Gramanet, Cataluña, Spain Novartis Investigative Site Alicante, Comunidad Valenciana, Spain, 03004 Novartis Investigative Site Torrevieja (Alicante), Comunidad Valenciana, Spain, 03186 Novartis Investigative Site Valencia, Comunidad Valenciana, Spain, 46010 Novartis Investigative Site Valencia, Comunidad Valenciana, Spain, 46014 Novartis Investigative Site Santiago de Compostela, Galicia, Spain, 15706 Novartis Investigative Site Galdakano, Pais Vasco, Spain, 48960 Novartis Investigative Site Bilbao, País Vasco, Spain, 48013 Novartis Investigative Site Vitoria, País Vasco, Spain Novartis Investigative Site Barcelona, Spain, 08006 Novartis Investigative Site Barcelona, Spain, 08025 Novartis Investigative Site Madrid, Spain, 28009 Novartis Investigative Site Madrid, Spain, 28035 Novartis Investigative Site Madrid, Spain, 28040 Novartis Investigative Site Madrid, Spain, 28041 Novartis Investigative Site Madrid, Spain, 28046 Novartis Investigative Site Santander, Spain, 39008 Less << |
NCT01409408 | Hypertension ... More >>Diabetes Mellitus Less << | Phase 4 | Withdrawn(Due to preliminary r... More >>esults of Altitude Trial.) Less << | December 2013 | Brazil ... More >> Hospital Universitario Pedro Ernesto Rio de Janeiro, Brazil, 20551030 Less << |
NCT01417104 | - | Terminated(Safety concerns wit... More >>h approved medication identified in an unrelated trial) Less << | - | - | |
NCT00853658 | - | Completed | - | - | |
NCT01176032 | - | Completed | - | - | |
NCT00654875 | Essential Hypertension | Phase 4 | Completed | - | United States, Ohio ... More >> Investigative Site Zanesville, Ohio, United States Germany Investigative Site Frankfurt, Germany Spain Investigative Site Valencia, Spain Less << |
NCT01113047 | Essential Hypertension | Phase 3 | Completed | - | Germany ... More >> Investigative Site Pirna, Germany Less << |
NCT00654875 | - | Completed | - | - | |
NCT01472796 | Hypertension | Phase 4 | Unknown | March 2014 | United States, Michigan ... More >> Wayne State University, 4201 St. Antoine Recruiting Detroit, Michigan, United States, 48201 Contact: Carol A Muzyk, CCRP 313-745-2378 cmuzyk@med.wayne.edu Contact: Donna Ford 888-235-5467 Principal Investigator: John M Flack, M.D., M.P.H. Less << |
NCT00414609 | Myocardial Infarction | Phase 3 | Completed | - | - |
NCT01056731 | High Blood Pressure | Phase 4 | Completed | - | Venezuela ... More >> Investigative Site Bolíva, Venezuela Investigative Site Carabobo, Venezuela Investigative Site Caracas, Venezuela Investigative Site Edo Zulia, Venezuela Investigative Site Estado Monagas, Venezuela Investigative Site Falcón, Venezuela Investigative Site Maracaibo Estado Zulia, Venezuela Less << |
NCT00414609 | - | Completed | - | - | |
NCT01318395 | Arterial Hypertension | Phase 3 | Completed | - | Germany ... More >> Clinical Research Unit, Department of Nephrology and Hypertension, University of Erlangen-Nürnberg Erlangen, Germany, 91054 Clinical Research Unit, Department of Nephrology and Hypertension, University of Erlangen-Nürnberg Nürnberg, Germany, 90471 Less << |
NCT00498433 | Hypertension ... More >>Abdominal Obesity Less << | Phase 2 | Terminated(Early termination r... More >>esulted from interim analysis of the ALTITUDE trial) Less << | - | Germany ... More >> Novartis Investigative Site Berlin-Buch, Germany, 13125 Novartis Investigative Site Hannover, Germany, 30159 Less << |
NCT00518765 | Hypertension | Phase 3 | Completed | - | United States, Massachusetts ... More >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Less << |
NCT01922141 | Hypertension | Phase 4 | Withdrawn | June 2018 | - |
NCT00660309 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | United States, Massachusetts ... More >> Novartis Investigator Site Boston, Massachusetts, United States, 02115 Less << |
NCT00498433 | - | Terminated(Early termination r... More >>esulted from interim analysis of the ALTITUDE trial) Less << | - | - | |
NCT00660309 | - | Completed | - | - | |
NCT00994253 | Hypertension ... More >>Diabetes Type 2 Less << | Phase 4 | Withdrawn(Due to safety concer... More >>ns re the concomitant use of aliskiren with an ACEi or ARB.) Less << | December 2012 | United States, Michigan ... More >> William Beaumont Hospital Royal Oak, Michigan, United States, 48073 Less << |
NCT00942994 | Hypertension | Phase 4 | Completed | - | United States, Arkansas ... More >> K and S Research Services Little Rock, Arkansas, United States, 72201 United States, Florida Well Pharma Medical Research South Miami, Florida, United States, 33143 United States, Massachusetts Hyde Park Health Associates Mattapan, Massachusetts, United States, 02126 United States, Virginia Manassas Clinical Research Center Manassas, Virginia, United States, 20110 United States, Washington Scriber Kidney Center Seattle, Washington, United States, 98133 Less << |
NCT01394770 | Hypertension|Dialysis | PHASE4 | UNKNOWN | 2025-09-12 | Second Univesity of Naples, Na... More >>ples, 80100, Italy Less << |
NCT01040494 | Congestive Heart Failure | Phase 4 | Unknown | January 2011 | Taiwan ... More >> National Taiwan University Hospital Not yet recruiting Taipei, Taiwan, 886 Contact: Lian-Yu Lin, MD, PhD +886-2-23123456 ext 65002 lin7010@ms1.hinet.net Principal Investigator: Lian-Yu Lin, MD, PhD Taipei Veteral General Hospital Not yet recruiting Taipei, Taiwan, 886 Contact: Chen-Huan Chen, MD, PhD +886-2-8712121 ext 2073 chench@vghtpe.gov.tw Principal Investigator: Chen-Huan Chen, MD, PhD Less << |
NCT01219413 | Chronic Kidney Disease ... More >> Proteinuria Blood Pressure Less << | Phase 4 | Completed | - | Poland ... More >> Medical University of Gdansk Gdansk, Pomorskie, Poland, 80-211 Less << |
NCT00441064 | Hypertension | PHASE4 | COMPLETED | 2025-11-07 | Novartis US, Orangevale, Calif... More >>ornia, United States|Novartis US, Brooklyn Center, Minnesota, United States|Novartis US, Butte, Montana, United States|Novartis US, Missoula, Montana, United States|Novartis US, Lincoln, Nebraska, United States|Novartis US, Johnson City, New York, United States|Novartis US, Asheboro, North Carolina, United States|Novartis US, Shelby, North Carolina, United States|Novartis US, Cincinnati, Ohio, United States|Novartis US, Kettering, Ohio, United States|Novartis US, Downington, Pennsylvania, United States|Novartis US, Erie, Pennsylvania, United States|Novartis US, Pittsburg, Pennsylvania, United States|Novartis US, Dallas, Texas, United States|Novartis US, Kingsport, Texas, United States|Novartis US, Bountiful, Utah, United States|Novartis US, Salt Lake City, Utah, United States|Novartis US, Port Orchard, Washington, United States|Novartis US, Madison, Wisconsin, United States Less << |
NCT01095822 | Diabetes Mellitus | Phase 4 | Unknown | March 2011 | United States, Maryland ... More >> Dr. Pokov's Polyclinic. 6821 Reisterstown Road Suite 206 Baltimore, Maryland, United States, 21215 Less << |
NCT00529451 | - | Completed | - | - | |
NCT00529451 | Hypertension | Phase 3 | Completed | - | China ... More >> Novartis Investigative Sites China, China India Novartis Investigative Sites India, India Thailand Novartis Investigative Sites Thailand, Thailand Less << |
NCT00441064 | Hypertension | PHASE4 | COMPLETED | 2025-11-07 | Novartis US, Orangevale, Calif... More >>ornia, United States|Novartis US, Brooklyn Center, Minnesota, United States|Novartis US, Butte, Montana, United States|Novartis US, Missoula, Montana, United States|Novartis US, Lincoln, Nebraska, United States|Novartis US, Johnson City, New York, United States|Novartis US, Asheboro, North Carolina, United States|Novartis US, Shelby, North Carolina, United States|Novartis US, Cincinnati, Ohio, United States|Novartis US, Kettering, Ohio, United States|Novartis US, Downington, Pennsylvania, United States|Novartis US, Erie, Pennsylvania, United States|Novartis US, Pittsburg, Pennsylvania, United States|Novartis US, Dallas, Texas, United States|Novartis US, Kingsport, Texas, United States|Novartis US, Bountiful, Utah, United States|Novartis US, Salt Lake City, Utah, United States|Novartis US, Port Orchard, Washington, United States|Novartis US, Madison, Wisconsin, United States Less << |
NCT02909166 | Atrial Fibrillation | Phase 3 | Unknown | December 2017 | Finland ... More >> Helsinki University Central Hospital Recruiting Helsinki, Finland, 00029 Contact: Mika Lehto, MD, PhD +358505447487 mika.lehto@hus.fi Contact: Jussi Niiranen, MD jussi.niiranen@hus.fi Less << |
NCT01519635 | Hypertension | Phase 4 | Unknown | October 2012 | Switzerland ... More >> Centre Hospitalier Universitaire Vaudois Recruiting Lausanne, Vaud, Switzerland, 1004 Contact: Michel Burnier, Professor 0041213141129 michel.burnier@huv.ch Sub-Investigator: Valentina Forni, MD Less << |
NCT02446548 | Albuminuria | Not Applicable | Completed | - | Poland ... More >> Medical University of Gdansk Gdansk, Pomorskie, Poland, 80-211 Less << |
NCT01349114 | - | Terminated(Sponsor requested t... More >>ermination.) Less << | - | - | |
NCT01235910 | Hypertension|Cardiac Transplan... More >>tation Less << | PHASE4 | TERMINATED | 2025-12-12 | University of Colorado Denver,... More >> Aurora, Colorado, 80045, United States Less << |
NCT01349114 | Diabetes Pre-... More >>hypertension Hypertension Less << | Phase 4 | Terminated(Sponsor requested t... More >>ermination.) Less << | - | United States, Alabama ... More >> UAB Birmingham, Alabama, United States, 35294 Less << |
NCT00949351 | Type 2 Diabetes With Nephropat... More >>hy Less << | Phase 4 | Unknown | September 2010 | Thailand ... More >> Lerdsin General Hospital Not yet recruiting Bangkok, Thailand, 10500 Contact: Krissanapong Manotham, Dr 662 3539799 ext 2501 kmanotham@hotmail.com Contact: Tanaporn Ratanasuwan, Dr tratanas@hotmail.com Principal Investigator: Krissanapong Manotham, Dr Less << |
NCT00982033 | - | Completed | - | - | |
NCT01437943 | Kidney Disease ... More >> Kidney Failure, Chronic Less << | Phase 4 | Terminated(Novartis has have d... More >>ecided to terminate all clinical investigator-initiated research projects involving aliskiren) Less << | - | United States, Massachusetts ... More >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Less << |
NCT01437943 | - | Terminated(Novartis has have d... More >>ecided to terminate all clinical investigator-initiated research projects involving aliskiren) Less << | - | - | |
NCT01093781 | Idiopathic Membranous Nephropa... More >>thy Less << | WITHDRAWN | 2025-12-11 | Mayo Clinic in Rochester, Roch... More >>ester, Minnesota, 55905, United States Less << | |
NCT01480791 | Hypertension ... More >>Diabetes Less << | Phase 2 | Withdrawn(Because of results o... More >>f Altitude trial, this trial was cancelled.) Less << | - | Canada, Quebec ... More >> Cardiovascular Prevention Centre, Jewish General Hospital Montreal, Quebec, Canada, H3T 1E2 Less << |
NCT01570686 | Hypertension | PHASE4 | COMPLETED | 2025-11-12 | Novartis Investigative Site, L... More >>os Angeles, California, 90057, United States|Novartis Investigative Site, Riverside, California, 92506, United States|Novartis Investigative Site, Santa Monica, California, 90404, United States|Novartis Investigative Site, Walnut Creek, California, 94598, United States|Novartis Investigative Site, Westlake Village, California, 91361, United States|Novartis Investigative Site, Coral Gables, Florida, 33134, United States|Novartis Investigative Site, Miami, Florida, 33169, United States|Novartis Investigative Site, South Miami, Florida, 33143, United States|Novartis Investigative Site, Chicago, Illinois, 60607, United States|Novartis Investigative Site, Chicago, Illinois, 60610, United States|Novartis Investigative Site, Evansville, Indiana, 47712, United States|Novartis Investigative Site, Topeka, Kansas, 66606, United States|Novartis Investigative Site, Opelousas, Louisiana, 70570, United States|Novartis Investigative Site, Chaska, Minnesota, 55318, United States|Novartis Investigative Site, Edina, Minnesota, 55435, United States|Novartis Investigative Site, St. Paul, Minnesota, 55114, United States|Novartis Investigative Site, Jackson, Mississippi, 39209, United States|Novartis Investigative Site, Picayune, Mississippi, 39466, United States|Novartis Investigative Site, St. Louis, Missouri, 63141, United States|Novartis Investigative Site, Charlotte, North Carolina, 28209, United States|Novartis Investigative Site, Greensboro, North Carolina, 27401, United States|Novartis Investigative Site, Greensboro, North Carolina, 27408, United States|Novartis Investigative Site, Salisbury, North Carolina, 28144, United States|Novartis Investigative Site, Shelby, North Carolina, 28152, United States|Novartis Investigative Site, Winston-Salem, North Carolina, 27103, United States|Novartis Investigative Site, Cincinnati, Ohio, 45246, United States|Novartis Investigative Site, Columbus, Ohio, 43213, United States|Novartis Investigative Site, Lyndhurst, Ohio, 44124, United States|Novartis Investigative Site, Marion, Ohio, 43302, United States|Novartis Investigative Site, Norman, Oklahoma, 73069, United States|Novartis Investigative Site, Eugene, Oregon, 97404, United States|Novartis Investigative Site, Oregon City, Oregon, 97045, United States|Novartis Investigative Site, Portland, Oregon, 97239, United States|Novartis Investigative Site, Knoxville, Tennessee, 37920, United States|Novartis Investigative Site, Beaumont, Texas, 77702, United States|Novartis Investigative Site, Houston, Texas, 77081, United States|Novartis Investigative Site, Lake Jackson, Texas, 77566, United States|Novartis Investigative Site, Pasadena, Texas, 77504, United States|Novartis Investigative Site, Centerville, Utah, 84104, United States|Novartis Investigative Site, Arlington, Virginia, 22203, United States|Novartis Investigative Site, Ettrick, Virginia, 23803, United States|Novartis Investigative Site, Midlothian, Virginia, 23114, United States|Novartis Investigative Site, Port Orchard, Washington, 98366, United States|Novartis Investigative Site, Moncton, New Brunswick, E1G 1A7, Canada|Novartis Investigative Site, St. John's, Newfoundland and Labrador, A1A 3R5, Canada|Novartis Investigative Site, Brampton, Ontario, L6T 0G1, Canada|Novartis Investigative Site, Toronto, Ontario, M9W 4L6, Canada|Novartis Investigative Site, Mirabel, Quebec, J7J 2K8, Canada|Novartis Investigative Site, Sainte-Foy, Quebec, G1W 4R4, Canada|Novartis Investigative Site, Pozzilli, IS, 86077, Italy|Novartis Investigative Site, Pavia, PV, 27100, Italy|Novartis Investigative Site, Sassari, SS, 07100, Italy|Novartis Investigative Site, Carolina, 00983, Puerto Rico|Novartis Investigative Site, Cidra, 00739, Puerto Rico|Novartis Investigative Site, Manati, 00674, Puerto Rico|Novartis Investigative Site, Banská Bystrica, Slovak republic, 97405, Slovakia|Novartis Investigative Site, Bratislava, Slovak republic, 83299, Slovakia|Novartis Investigative Site, Kosice, Slovak Republic, 040 11, Slovakia|Novartis Investigative Site, Kosice, Slovak republic, 04001, Slovakia|Novartis Investigative Site, Nitra, Slovak republic, 95201, Slovakia|Novartis Investigative Site, Rimavska Sobota, Slovak republic, 97901, Slovakia|Novartis Investigative Site, Senec, Slovak republic, 90301, Slovakia|Novartis Investigative Site, Snina, Slovak republic, 09601, Slovakia|Novartis Investigative Site, Svidnik, Slovak Republic, 08901, Slovakia|Novartis Investigative Site, Trnava, Slovak republic, 91701, Slovakia|Novartis Investigative Site, Bratislava, 821 07, Slovakia|Novartis Investigative Site, Martin, 036 01, Slovakia|Novartis Investigative Site, Presov, 080 01, Slovakia|Novartis Investigative Site, Sala, 927 03, Slovakia|Novartis Investigative Site, Zvolen, 960 01, Slovakia|Novartis Investigative Site, Barcelona, Catalu?a, 08905, Spain|Novartis Investigative Site, Centelles, Catalu?a, 08540, Spain|Novartis Investigative Site, Corbera de Llobregat, Catalu?a, 08757, Spain|Novartis Investigative Site, Hostalets de Balenya, Catalu?a, 08550, Spain|Novartis Investigative Site, Vic, Catalu?a, 08500, Spain|Novartis Investigative Site, Alzira, Comunidad Valenciana, 46600, Spain|Novartis Investigative Site, Quart de Poblet, Comunidad Valenciana, 46930, Spain|Novartis Investigative Site, Madrid, 28009, Spain|Novartis Investigative Site, Taipei, Taiwan, ROC, 112, Taiwan|Novartis Investigative Site, Changhua, 500, Taiwan|Novartis Investigative Site, Taichung, 40447, Taiwan|Novartis Investigative Site, Taipei, 10002, Taiwan|Novartis Investigative Site, Taipei, 114, Taiwan Less << |
NCT01570686 | Hypertension | PHASE4 | COMPLETED | 2025-11-12 | Novartis Investigative Site, L... More >>os Angeles, California, 90057, United States|Novartis Investigative Site, Riverside, California, 92506, United States|Novartis Investigative Site, Santa Monica, California, 90404, United States|Novartis Investigative Site, Walnut Creek, California, 94598, United States|Novartis Investigative Site, Westlake Village, California, 91361, United States|Novartis Investigative Site, Coral Gables, Florida, 33134, United States|Novartis Investigative Site, Miami, Florida, 33169, United States|Novartis Investigative Site, South Miami, Florida, 33143, United States|Novartis Investigative Site, Chicago, Illinois, 60607, United States|Novartis Investigative Site, Chicago, Illinois, 60610, United States|Novartis Investigative Site, Evansville, Indiana, 47712, United States|Novartis Investigative Site, Topeka, Kansas, 66606, United States|Novartis Investigative Site, Opelousas, Louisiana, 70570, United States|Novartis Investigative Site, Chaska, Minnesota, 55318, United States|Novartis Investigative Site, Edina, Minnesota, 55435, United States|Novartis Investigative Site, St. Paul, Minnesota, 55114, United States|Novartis Investigative Site, Jackson, Mississippi, 39209, United States|Novartis Investigative Site, Picayune, Mississippi, 39466, United States|Novartis Investigative Site, St. Louis, Missouri, 63141, United States|Novartis Investigative Site, Charlotte, North Carolina, 28209, United States|Novartis Investigative Site, Greensboro, North Carolina, 27401, United States|Novartis Investigative Site, Greensboro, North Carolina, 27408, United States|Novartis Investigative Site, Salisbury, North Carolina, 28144, United States|Novartis Investigative Site, Shelby, North Carolina, 28152, United States|Novartis Investigative Site, Winston-Salem, North Carolina, 27103, United States|Novartis Investigative Site, Cincinnati, Ohio, 45246, United States|Novartis Investigative Site, Columbus, Ohio, 43213, United States|Novartis Investigative Site, Lyndhurst, Ohio, 44124, United States|Novartis Investigative Site, Marion, Ohio, 43302, United States|Novartis Investigative Site, Norman, Oklahoma, 73069, United States|Novartis Investigative Site, Eugene, Oregon, 97404, United States|Novartis Investigative Site, Oregon City, Oregon, 97045, United States|Novartis Investigative Site, Portland, Oregon, 97239, United States|Novartis Investigative Site, Knoxville, Tennessee, 37920, United States|Novartis Investigative Site, Beaumont, Texas, 77702, United States|Novartis Investigative Site, Houston, Texas, 77081, United States|Novartis Investigative Site, Lake Jackson, Texas, 77566, United States|Novartis Investigative Site, Pasadena, Texas, 77504, United States|Novartis Investigative Site, Centerville, Utah, 84104, United States|Novartis Investigative Site, Arlington, Virginia, 22203, United States|Novartis Investigative Site, Ettrick, Virginia, 23803, United States|Novartis Investigative Site, Midlothian, Virginia, 23114, United States|Novartis Investigative Site, Port Orchard, Washington, 98366, United States|Novartis Investigative Site, Moncton, New Brunswick, E1G 1A7, Canada|Novartis Investigative Site, St. John's, Newfoundland and Labrador, A1A 3R5, Canada|Novartis Investigative Site, Brampton, Ontario, L6T 0G1, Canada|Novartis Investigative Site, Toronto, Ontario, M9W 4L6, Canada|Novartis Investigative Site, Mirabel, Quebec, J7J 2K8, Canada|Novartis Investigative Site, Sainte-Foy, Quebec, G1W 4R4, Canada|Novartis Investigative Site, Pozzilli, IS, 86077, Italy|Novartis Investigative Site, Pavia, PV, 27100, Italy|Novartis Investigative Site, Sassari, SS, 07100, Italy|Novartis Investigative Site, Carolina, 00983, Puerto Rico|Novartis Investigative Site, Cidra, 00739, Puerto Rico|Novartis Investigative Site, Manati, 00674, Puerto Rico|Novartis Investigative Site, Banská Bystrica, Slovak republic, 97405, Slovakia|Novartis Investigative Site, Bratislava, Slovak republic, 83299, Slovakia|Novartis Investigative Site, Kosice, Slovak Republic, 040 11, Slovakia|Novartis Investigative Site, Kosice, Slovak republic, 04001, Slovakia|Novartis Investigative Site, Nitra, Slovak republic, 95201, Slovakia|Novartis Investigative Site, Rimavska Sobota, Slovak republic, 97901, Slovakia|Novartis Investigative Site, Senec, Slovak republic, 90301, Slovakia|Novartis Investigative Site, Snina, Slovak republic, 09601, Slovakia|Novartis Investigative Site, Svidnik, Slovak Republic, 08901, Slovakia|Novartis Investigative Site, Trnava, Slovak republic, 91701, Slovakia|Novartis Investigative Site, Bratislava, 821 07, Slovakia|Novartis Investigative Site, Martin, 036 01, Slovakia|Novartis Investigative Site, Presov, 080 01, Slovakia|Novartis Investigative Site, Sala, 927 03, Slovakia|Novartis Investigative Site, Zvolen, 960 01, Slovakia|Novartis Investigative Site, Barcelona, Catalu?a, 08905, Spain|Novartis Investigative Site, Centelles, Catalu?a, 08540, Spain|Novartis Investigative Site, Corbera de Llobregat, Catalu?a, 08757, Spain|Novartis Investigative Site, Hostalets de Balenya, Catalu?a, 08550, Spain|Novartis Investigative Site, Vic, Catalu?a, 08500, Spain|Novartis Investigative Site, Alzira, Comunidad Valenciana, 46600, Spain|Novartis Investigative Site, Quart de Poblet, Comunidad Valenciana, 46930, Spain|Novartis Investigative Site, Madrid, 28009, Spain|Novartis Investigative Site, Taipei, Taiwan, ROC, 112, Taiwan|Novartis Investigative Site, Changhua, 500, Taiwan|Novartis Investigative Site, Taichung, 40447, Taiwan|Novartis Investigative Site, Taipei, 10002, Taiwan|Novartis Investigative Site, Taipei, 114, Taiwan Less << |
NCT01568775 | End Stage Renal Disease | PHASE1 | COMPLETED | 2025-09-10 | Charité Universit?tsmedizin, B... More >>erlin, Germany Less << |
NCT00982033 | Heart Failure | Phase 4 | Completed | - | United States, North Carolina ... More >> Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157 Less << |
NCT00942994 | - | Completed | - | - | |
NCT01235910 | Hypertension|Cardiac Transplan... More >>tation Less << | PHASE4 | TERMINATED | 2025-12-12 | University of Colorado Denver,... More >> Aurora, Colorado, 80045, United States Less << |
NCT01298258 | Heart Failure | UNKNOWN | 2025-07-13 | Taipei Veterans General Hospit... More >>al, Taipei, Taiwan Less << | |
NCT00262236 | Hypertension | PHASE3 | COMPLETED | 2025-08-06 | Investigative Centers, Germany... More >>|Novartis, Basel, Switzerland Less << |
NCT00344110 | Hypertension | PHASE3 | COMPLETED | 2025-04-07 | Novartis Pharmaceuticals, Japa... More >>n, Japan Less << |
NCT00294710 | Hypertension | PHASE3 | COMPLETED | 2025-07-06 | Novartis, East Hanover, New Je... More >>rsey, 07936, United States|Investigative Centers, Germany Less << |
NCT00311012 | Hypertension | PHASE2 | COMPLETED | 2025-03-05 | Novartis Pharmaceuticals, Toky... More >>o, Japan Less << |
NCT01156207 | Heart Failure | PHASE4 | UNKNOWN | - | National Taiwan University Hos... More >>pital, Taipei, Taiwan|Taipei Veterans General Hospital, Taipei, Taiwan Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
1.81mL 0.36mL 0.18mL |
9.06mL 1.81mL 0.91mL |
18.12mL 3.62mL 1.81mL |
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Dissolving Methods |
in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:
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