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Chemical Structure| 168618-92-6 Chemical Structure| 168618-92-6

Structure of 168618-92-6

Chemical Structure| 168618-92-6

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Product Details of [ 168618-92-6 ]

CAS No. :168618-92-6
Formula : C14H11ClO2
M.W : 246.69
SMILES Code : COC(C1=CC(C2=CC(Cl)=CC=C2)=CC=C1)=O
MDL No. :MFCD05979711

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Application In Synthesis of [ 168618-92-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 168618-92-6 ]

[ 168618-92-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 618-89-3 ]
  • [ 63503-60-6 ]
  • [ 168618-92-6 ]
YieldReaction ConditionsOperation in experiment
89% General procedure: A solution of sodium carbonate (0.55mmol) in water (1.75mL) and EtOH (1.25mL) was prepared and degassed. In a 10mL vial Tetrakis (triphenylphosphine) palladium (0.055mmol) was added to a solution of 4a-e (0.275mmol) in DME (5mL) in a 10mL vial. Argon was bubbled into the DME solution with stirring for 10min. The boronic acid (1.650mmol) was added to the vial followed by the addition of the sodium carbonate mixture. The vial was sealed under argon and heated to 80C while stiring for 12h. The mixture was diluted in water and extracted with ethyl acetate. The extracts were washed with brine and dried over magnesium sulfate. The mixture was concentrated in vacuo to give the product as an oil. The product was purified in by column chromatography and characterized by 1H and 13C NMR.
 

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