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Chemical Structure| 167158-70-5 Chemical Structure| 167158-70-5

Structure of 167158-70-5

Chemical Structure| 167158-70-5

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Product Details of [ 167158-70-5 ]

CAS No. :167158-70-5
Formula : C8H4BrClN2O
M.W : 259.49
SMILES Code : ClC1=NC2=CC=C(Br)C=C2C(=O)N1
MDL No. :MFCD11101032
InChI Key :WZVAPPYRAGWFKW-UHFFFAOYSA-N
Pubchem ID :135659313

Safety of [ 167158-70-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 167158-70-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 167158-70-5 ]

[ 167158-70-5 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 102393-82-8 ]
  • [ 167158-70-5 ]
YieldReaction ConditionsOperation in experiment
87%
Stage #1: With sodium hydroxide In tetrahydrofuran at 20℃; for 2.5 h;
Stage #2: With acetic acid In tetrahydrofuran at 0℃;
Step C6-bromo-2-chloro-4(1H)-quinazolinone[00125] A solution of 6-bromo-2,4-dichloroquinazoline (2.0 g, 7.20 mmol) in THF (17.99 mL) was treated with 1N NaOH (17.99 mL, 17.99 mmol) and stirred at room temperature for 2.5 hours. The solution was cooled to 0 °C and the pH was adjusted to 5 with AcOH. The resulting light yellow solid was filtered and rinsed with water. The solid was concentrated from toluene (3x) to remove any residual water, which yielded 6-bromo-2-chloro-4(1H)-quinazolinone (1.625 g, 87percent). ES-LCMS: 259.0, 261.0 (M+1).
References: [1] Patent: WO2012/87938, 2012, A1, . Location in patent: Page/Page column 114.
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 10, p. 2297 - 2300.
  • 2
  • [ 88145-89-5 ]
  • [ 167158-70-5 ]
References: [1] Journal of Medicinal Chemistry, 2007, vol. 50, # 10, p. 2297 - 2300.
[2] Patent: WO2012/87938, 2012, A1, .
  • 3
  • [ 52727-57-8 ]
  • [ 167158-70-5 ]
References: [1] Journal of Medicinal Chemistry, 2007, vol. 50, # 10, p. 2297 - 2300.
[2] Patent: WO2012/87938, 2012, A1, .
 

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