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Structure of 163213-19-2

Chemical Structure| 163213-19-2

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Product Details of [ 163213-19-2 ]

CAS No. :163213-19-2
Formula : C10H15N3O2
M.W : 209.25
SMILES Code : O=C(OC(C)(C)C)C1=CN=C(NN)C=C1
MDL No. :MFCD16659034
InChI Key :LGHKHMSCVFCTRZ-UHFFFAOYSA-N
Pubchem ID :45089857

Safety of [ 163213-19-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 163213-19-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 163213-19-2 ]

[ 163213-19-2 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 115309-57-4 ]
  • [ 163213-19-2 ]
YieldReaction ConditionsOperation in experiment
78% With hydrazine hydrate In ethanol at 100℃; for 2 h; 18.0 g (84.2 mmol) of tert-butyl 6-chloropyridine-3-carboxylate are initially charged in 85 ml of ethanol. 42.2 g (842.0 mmol) of hydrazine hydrate are added, and the mixture is stirred at 100° C. for 2 h.
The mixture is then concentrated, and the residue is taken up in a mixture of ethyl acetate and water.
The phases are separated, and the organic phase is washed once with water and once with saturated sodium chloride solution, dried over magnesium sulfate and concentrated again.
The residue is triturated with petroleum ether, and the solid formed is filtered off and dried under high vacuum.
Yield: 16.4 g (78percent of theory)
LC-MS (Method 1): Rt=2.30 min; MS (ESIpos): m/z=210 [M+H]+;
1H-NMR (400 MHz, DMSO-d6): δ=8.49 (d, 1H), 8.30 (s, 1H), 7.82 (dd, 1H), 6.70 (d, 1H), 4.35 (s, 2H), 1.50 (s, 9H).
References: [1] Journal of Heterocyclic Chemistry, 2012, vol. 49, # 2, p. 442 - 445.
[2] Patent: US2010/93803, 2010, A1, . Location in patent: Page/Page column 21-22.
  • 2
  • [ 5326-23-8 ]
  • [ 163213-19-2 ]
References: [1] Journal of Heterocyclic Chemistry, 2012, vol. 49, # 2, p. 442 - 445.
 

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