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Chemical Structure| 1620576-09-1 Chemical Structure| 1620576-09-1

Structure of 1620576-09-1

Chemical Structure| 1620576-09-1

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Product Details of [ 1620576-09-1 ]

CAS No. :1620576-09-1
Formula : C6H9IN2
M.W : 236.05
SMILES Code : CC(C1=CC(I)=NN1)C

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Application In Synthesis of [ 1620576-09-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1620576-09-1 ]

[ 1620576-09-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 56367-24-9 ]
  • [ 1620576-09-1 ]
YieldReaction ConditionsOperation in experiment
64% To a cooled solution of <strong>[56367-24-9]5-isopropyl-1H-pyrazol-3-amine</strong> (1 g, 7.9 mmol) in acetonitrile (50 mL) was added 4-methylbenzenesulfonic acid (2.8 g, 20 mmol) and at 0 C dropwise solution of sodium nitrite in water (10 mL). Upon completion the reaction mixture was stirred a further 30 mmat 0 C. A solution of sodium iodide (6 g, 40 mmol) in water (10 mL) was slowly added dropwise at0 C to the reaction mixture and stirred at RT for 3 h. The mixture was concentrated to dryness invacuo, dissolved in ethyl acetate (150 mL), washed with water, brine and dried over sodium sulphate. The organic layer was concentrated to dryness in vacuo and the resulting residue was purified by column chromatography (silica gel, 100-200 mesh, 20% ethyl acetate in hexane) affording 3-iodo-5-isopropyl-1H-pyrazole (1.2 g, 64%): 1H NMR (400MHz, DMSO-d6) ö: 6.20 (s, 1H), 3.10-2.75 (m, 1H), 1.19 (d, J = 7.0 Hz, 6H).
 

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